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Naphthalene Derivates from Bawang Tiwai Bulb Eleutherine Bulbosa in Borneo

al Kimiya: Jurnal Ilmu Kimia dan Terapan · Vol. 11 No. 1 (2024) · hlm. 61–67

DOI
10.15575/ak.v11i1.35515
ISSN
2407-1927, 2407-1897
Terbit
2024-08-01
Penerbit
Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung
Bahasa
eng

Abstrak

Naphthalene derivative compounds named Eleutherol (1) and Eleutherol C (2) have been isolated from Bawang Tiwai Bulb Eleutherine bulbosa. We tested its cytotoxic activity against T47D breast cancer cells in vitro after isolating compounds 1 and 2 from the EtOH extract using conventional chromatography methods. Their chemical structures were elucidated based on spectroscopic analysis, including IR, HR-TOFMS, 1D, and 2D NMR, and by comparison to those related spectra previously reported. Compounds 1 and 2 were tested for their cytotoxic effects against T47D breast cancer cells and showed moderate cytotoxicity against T47D breast cancer cells with IC50 values of 117.15 and 80.21 µM, respectively, compared with cisplatin 24.07 µM.

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  • Universitas Halu Oleo
  • Universitas Ahmad Dahlan
  • Institut Seni Budaya Indonesia Aceh
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Rekan penulisOrganisasiArtikel bersama
Handrawan HandrawanUniversitas Halu Oleo3
Rahman HasimaUniversitas Halu Oleo3
Unang SupratmanAfiliasi tidak diketahui3
Oheo K. HarisAfiliasi tidak diketahui2
Safril Sofwan SanibUniversitas Halu Oleo2
Dewi Indriyani RoslimAfiliasi tidak diketahui2
Moh. FadhilAfiliasi tidak diketahui2
Nguyen Van ThaoAfiliasi tidak diketahui2
Nanda SaputraAfiliasi tidak diketahui2
Jamaluddin IdrisAfiliasi tidak diketahui2
Ahmad SarbiniAfiliasi tidak diketahui2
Hadi KuncoroAfiliasi tidak diketahui2
Kindi FarabiAfiliasi tidak diketahui2
Euis JulaehaAfiliasi tidak diketahui2
Yoshihito ShionoAfiliasi tidak diketahui2
Tri Stiyo FamujiUniversitas Ahmad Dahlan1
Sunardi SunardiUniversitas Ahmad Dahlan1
Muhammad Kunta BiddinikaUniversitas Ahmad Dahlan1
Aldibangun Pidekso PutroAfiliasi tidak diketahui1
Mustafa MustafaInstitut Seni Budaya Indonesia Aceh1
Vivi Fatmawati A.Afiliasi tidak diketahui1
Ahmad AhmadAfiliasi tidak diketahui1
Makkulau MakkulauUniversitas Halu Oleo1
Fahinu FahinuAfiliasi tidak diketahui1
Muhammad TaufikUniversitas Halu Oleo1
H S GusnawatyUniversitas Halu Oleo1
Deity YuningsihUniversitas Halu Oleo1
St. Muslimah SuciatiUniversitas Halu Oleo1
Haris YusufUniversitas Halu Oleo1
La Ode M. SulihinAfiliasi tidak diketahui1
Heryanti HeryantiAfiliasi tidak diketahui1
Faculty of science, Sumatera Institute of Technology, 35365, Indonesia Department of PhysicsAfiliasi tidak diketahui1
Faculty of science, Sumatera Institute of Technology, 35365, Indonesia Department of Master PhysicsAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.uinsgd.ac.id/index.php/ak/oai, pertama di-harvest 7 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Naphthalene Derivates from Bawang Tiwai Bulb Eleutherine Bulbosa in Borneo</dc:title>
	<dc:creator>Salam, Supriatno</dc:creator>
	<dc:creator>Hikmawan, Baso Didik</dc:creator>
	<dc:creator>Samsul, Erwin</dc:creator>
	<dc:creator>Herman, Herman</dc:creator>
	<dc:creator>Ahmad, Islamudin</dc:creator>
	<dc:creator>Rijai, Laode</dc:creator>
	<dc:creator>Nafiah, Mohd Azlan</dc:creator>
	<dc:subject xml:lang="en-US">Eleutherine bulbosa</dc:subject>
	<dc:subject xml:lang="en-US">Eleutherol</dc:subject>
	<dc:subject xml:lang="en-US">Eleutherol C</dc:subject>
	<dc:subject xml:lang="en-US">T47D breast cancer</dc:subject>
	<dc:subject xml:lang="en-US">East Kalimantan.</dc:subject>
	<dc:description xml:lang="en-US">Naphthalene derivative compounds named Eleutherol (1) and Eleutherol C (2) have been isolated from Bawang Tiwai Bulb Eleutherine bulbosa. We tested its cytotoxic activity against T47D breast cancer cells in vitro after isolating compounds 1 and 2 from the EtOH extract using conventional chromatography methods. Their chemical structures were elucidated based on spectroscopic analysis, including IR, HR-TOFMS, 1D, and 2D NMR, and by comparison to those related spectra previously reported. Compounds 1 and 2 were tested for their cytotoxic effects against T47D breast cancer cells and showed moderate cytotoxicity against T47D breast cancer cells with IC50 values of 117.15 and 80.21 µM, respectively, compared with cisplatin 24.07 µM.</dc:description>
	<dc:publisher xml:lang="en-US">Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung</dc:publisher>
	<dc:date>2024-08-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/vnd.openxmlformats-officedocument.wordprocessingml.document</dc:format>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.uinsgd.ac.id/index.php/ak/article/view/35515</dc:identifier>
	<dc:identifier>10.15575/ak.v11i1.35515</dc:identifier>
	<dc:source xml:lang="en-US">al Kimiya: Jurnal Ilmu Kimia dan Terapan; Vol. 11 No. 1 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan; 61-67</dc:source>
	<dc:source>2407-1927</dc:source>
	<dc:source>2407-1897</dc:source>
	<dc:source>10.15575/ak.v11i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinsgd.ac.id/index.php/ak/article/view/35515/13457</dc:relation>
	<dc:relation>https://journal.uinsgd.ac.id/index.php/ak/article/view/35515/11208</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 Supriatno Salam</dc:rights>
</oai_dc:dc>