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Immunomodulatory Activity of Allium sativum, Curcuma mangga, and Acorus calamus Combination Nanoparticle on Mice Leukocytes Profile

Jurnal Biodjati · Vol. 7 No. 1 (2022) · hlm. 25–35

DOI
10.15575/biodjati.v7i1.11879
ISSN
2541-4208, 2548-1606
Terbit
2022-05-30
Penerbit
UIN Sunan Gunung Djati Bandung
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-nd/4.0

Abstrak

Immunomodulators are substances acting as stimulants or suppressants against the immune system, either to specific or non-specific activity. The non-specific through the production of leukocytes as the first response in fighting against an attacking antigen. Meanwhile, the specific, hrough recognition of antigens by lymphocytes during reattack. This research aimed to determine the immunomodulatory activity of the extracts combination nanoparticles of Allium sativum, Curcuma mangga, and Acorus calamus on the leukocyte profile of mice. This study used 5 treatments and 6 repetitions. The treatment groups were K- (untreated group), P1 (extracts combination nanoparticle dose of 25 mg/kg), P2 (extracts combination nanoparticle dose of 50 mg / kg), P3 (subur kandungan herbal medicine dose of 75 mg / kg), and P4 (Clomiphene citrate dose of 0.9 mg / kgBW). The parameters used included the total number of leukocytes and their differential value. The data that met the parametric assumptions, such as normally distributed and homogeneous were examined using the One Way ANOVA test, and when there was a significant difference, it was processed with the Duncan assessment. While those that did not meet the assumptions were evaluated using a non-parametric analysis. The statistical results showed that administration of extracts combination nanoparticles of A. sativum, C. mangga, and A. calamus at doses of 25 mg/kg and 50 mg/kg were able to suppress the inflammatory reaction by decreasing the total number of leukocytes. However, the differential leukocyte count was able to maintained or modulate immune system, indicating by the percentage of neutrophil, basophil, and eosinophil in the normal range. At a dose of 50 mg/kg, decreased the percentage of lymphocytes, while for monocytes, all dosage ranges were able to increase their number.

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  • Universitas Airlangga
  • Universitas Islam Negeri Maulana Malik Ibrahim
  • Indonesia Open University
  • Universiti Sains Malaysia
  • State University of Malang
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Rekan penulisOrganisasiArtikel bersama
Vuanghao LimUniversiti Sains Malaysia2
Erna AgustinaUniversitas Islam Negeri Maulana Malik Ibrahim2
Ana Mar'a Konita FirdausUniversitas Islam Negeri Maulana Malik Ibrahim2
Eko Budi MinarnoUniversitas Islam Negeri Maulana Malik Ibrahim2
Mei RhomawatiUniversitas Islam Negeri Maulana Malik Ibrahim2
Maharani Retna DuhitaUniversitas Islam Negeri Maulana Malik Ibrahim2
Wira Eka PutraState University of Malang2
Firli Rahmah Primula DewiUniversitas Airlangga1
Sri Puji Astuti WahyuningsihUniversitas Airlangga1
Adelah Putri Milenia SariUniversitas Airlangga1
Umi Nur AlfiahUniversitas Airlangga1
Ummi ZubaidahUniversitas Airlangga1
Sugiharto -Universitas Airlangga1
AunurohimAfiliasi tidak diketahui1
Putri Alicia DewiUniversitas Airlangga1
Maya SafitriUniversitas Airlangga1
Farah Annisa NurbaniUniversitas Airlangga1
Manikya PramudyaUniversitas Airlangga1
A. R SeptianiUniversitas Airlangga1
Allam Thoriq NashrullohUniversitas Airlangga1
Muhammad Hilman Fuadil AminAfiliasi tidak diketahui1
Khusnita GiartiUniversitas Airlangga1
Yuli WinarsihUniversitas Airlangga1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.uinsgd.ac.id/index.php/biodjati/oai, pertama di-harvest 7 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Immunomodulatory Activity of Allium sativum, Curcuma mangga, and Acorus calamus Combination Nanoparticle on Mice Leukocytes Profile</dc:title>
	<dc:creator>Muchtaromah, Bayyinatul</dc:creator>
	<dc:creator>Analisa, Nur Izzah</dc:creator>
	<dc:creator>Ahmad, Mujahidin</dc:creator>
	<dc:creator>Fitriasari, Prilya Dewi</dc:creator>
	<dc:creator>Habibi, Soraya</dc:creator>
	<dc:creator>Hayati, Alfiah</dc:creator>
	<dc:creator>Fajriyah, Ely Nuril</dc:creator>
	<dc:subject xml:lang="en-US">Nanoparticle</dc:subject>
	<dc:subject xml:lang="en-US">Allium sativum</dc:subject>
	<dc:subject xml:lang="en-US">Curcuma mangga</dc:subject>
	<dc:subject xml:lang="en-US">Acorus calamus</dc:subject>
	<dc:subject xml:lang="en-US">Leukocyte</dc:subject>
	<dc:description xml:lang="en-US">Immunomodulators are substances acting as stimulants or suppressants against the immune system, either to specific or non-specific activity. The non-specific through the production of leukocytes as the first response in fighting against an attacking antigen. Meanwhile, the specific, hrough recognition of antigens by lymphocytes during reattack. This research aimed to determine the immunomodulatory activity of the extracts combination nanoparticles of Allium sativum, Curcuma mangga, and Acorus calamus on the leukocyte profile of mice. This study used 5 treatments and 6 repetitions. The treatment groups were K- (untreated group), P1 (extracts combination nanoparticle dose of 25 mg/kg), P2 (extracts combination nanoparticle dose of 50 mg / kg), P3 (subur kandungan herbal medicine dose of 75 mg / kg), and P4 (Clomiphene citrate dose of 0.9 mg / kgBW). The parameters used included the total number of leukocytes and their differential value. The data that met the parametric assumptions, such as normally distributed and homogeneous were examined using the One Way ANOVA test, and when there was a significant difference, it was processed with the Duncan assessment. While those that did not meet the assumptions were evaluated using a non-parametric analysis. The statistical results showed that administration of extracts combination nanoparticles of A. sativum, C. mangga, and A. calamus at doses of 25 mg/kg and 50 mg/kg were able to suppress the inflammatory reaction by decreasing the total number of leukocytes. However, the differential leukocyte count was able to maintained or modulate immune system, indicating by the percentage of neutrophil, basophil, and eosinophil in the normal range. At a dose of 50 mg/kg, decreased the percentage of lymphocytes, while for monocytes, all dosage ranges were able to increase their number.</dc:description>
	<dc:publisher xml:lang="en-US">UIN Sunan Gunung Djati Bandung</dc:publisher>
	<dc:date>2022-05-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.uinsgd.ac.id/index.php/biodjati/article/view/11879</dc:identifier>
	<dc:identifier>10.15575/biodjati.v7i1.11879</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Biodjati; Vol. 7 No. 1 (2022): May; 25-35</dc:source>
	<dc:source xml:lang="id-ID">Jurnal Biodjati; Vol 7 No 1 (2022): May; 25-35</dc:source>
	<dc:source>2541-4208</dc:source>
	<dc:source>2548-1606</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinsgd.ac.id/index.php/biodjati/article/view/11879/6989</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Jurnal Biodjati</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-nc-nd/4.0</dc:rights>
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