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Allopurinol Induction on Histopathological Structure of the Liver in Male Mice (Mus musculus)

Jurnal Biodjati · Vol. 7 No. 2 (2022) · hlm. 280–291

DOI
10.15575/biodjati.v7i2.18616
ISSN
2541-4208, 2548-1606
Terbit
2022-11-30
Penerbit
UIN Sunan Gunung Djati Bandung
Bahasa
eng

Abstrak

Allopurinol is used to reduce total uric acid levels in the body into oxypurinol which can inhibit xanthine oxidase. Allopurinol inhibits the precursors of uric acid formation, xanthine, and hypoxanthine. However, consumption of the drugs can cause side effects on the liver. The aim of the research was to determine the effect of allopurinol induction on the liver histopathology of male mice (Mus musculus) DDY strain. The method used in this research was an experimental design used post-test only that was divided into 4 groups of 4 mice per group. The control group (P0) was given 0.5% Na-CMC, and groups I, II, and III (P1, P2, and P3) were induced by allopurinol at 10 mg/kg BW, 20 mg/kg BW, and 30 mg/kg BW for 14 days. Allopurinol induction was performed by oral gavage. The results of the research showed that treatment with allopurinol caused changes in the mice’s body weight, liver index, liver morphology, and histological structure of the liver tissue, including necrosis, steatosis, leukocyte infiltration, binuclear hepatocytes, hepatocyte swelling, congestion, sinusoid dilatation, and hemorrhage. The level of liver damage increased in line with the dose used. This research indicated that the higher the allopurinol level, the higher the level of alteration in the liver section structure. Long-term use of allopurinol can cause damage to the structure of mice liver (liver toxicity).Â

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  • University of Bengkulu
  • University of Malaya
  • Universitas Sumatera Utara
  • Kaohsiung Medical University
  • National Research and Innovation Agency
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Rekan penulisOrganisasiArtikel bersama
Sipriyadi SipriyadiUniversity of Bengkulu3
Santi Nurul KamilahUniversity of Bengkulu2
SipriyadiUniversity of Bengkulu2
Syukriah SyukriahUniversitas Sumatera Utara2
Risky Hadi WibowoAfiliasi tidak diketahui2
FatimatuzzahraAfiliasi tidak diketahui1
Widya C. ManurungAfiliasi tidak diketahui1
Hery HaryantoAfiliasi tidak diketahui1
Choirul MuslimAfiliasi tidak diketahui1
Santi Nurul KamilahUniversity of Bengkulu1
Fepta AryantiUniversity of Bengkulu1
Jarulis JarulisUniversity of Bengkulu1
Putri Hezekiel Claracia SimanjuntakUniversity of Bengkulu1
Yar JohanUniversity of Bengkulu1
Noorhidayah MamatUniversity of Malaya1
Hengki TurnandoUniversity of Bengkulu1
Muhammad Rasul Abdullah HalimUniversity of Malaya1
Widya Pintaka Bayu PutraNational Research and Innovation Agency1
Apriza Hongko PutraKaohsiung Medical University1
Ahmad PariansyahAfiliasi tidak diketahui1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://journal.uinsgd.ac.id/index.php/biodjati/oai, pertama di-harvest 7 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Allopurinol Induction on Histopathological Structure of the Liver in Male Mice (Mus musculus)</dc:title>
	<dc:creator>Lestari, Dian Fita</dc:creator>
	<dc:creator>Fatimatuzzahra, Fatimatuzzahra</dc:creator>
	<dc:creator>Sianipar, Agnes Petra</dc:creator>
	<dc:creator>Wulansari, Shahnaz Shabrina</dc:creator>
	<dc:subject xml:lang="en-US">allopurinol</dc:subject>
	<dc:subject xml:lang="en-US">histopathology</dc:subject>
	<dc:subject xml:lang="en-US">liver</dc:subject>
	<dc:description xml:lang="en-US">Allopurinol is used to reduce total uric acid levels in the body into oxypurinol which can inhibit xanthine oxidase. Allopurinol inhibits the precursors of uric acid formation, xanthine, and hypoxanthine. However, consumption of the drugs can cause side effects on the liver. The aim of the research was to determine the effect of allopurinol induction on the liver histopathology of male mice (Mus musculus) DDY strain. The method used in this research was an experimental design used post-test only that was divided into 4 groups of 4 mice per group. The control group (P0) was given 0.5% Na-CMC, and groups I, II, and III (P1, P2, and P3) were induced by allopurinol at 10 mg/kg BW, 20 mg/kg BW, and 30 mg/kg BW for 14 days. Allopurinol induction was performed by oral gavage. The results of the research showed that treatment with allopurinol caused changes in the mice’s body weight, liver index, liver morphology, and histological structure of the liver tissue, including necrosis, steatosis, leukocyte infiltration, binuclear hepatocytes, hepatocyte swelling, congestion, sinusoid dilatation, and hemorrhage. The level of liver damage increased in line with the dose used. This research indicated that the higher the allopurinol level, the higher the level of alteration in the liver section structure. Long-term use of allopurinol can cause damage to the structure of mice liver (liver toxicity). </dc:description>
	<dc:publisher xml:lang="en-US">UIN Sunan Gunung Djati Bandung</dc:publisher>
	<dc:date>2022-11-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.uinsgd.ac.id/index.php/biodjati/article/view/18616</dc:identifier>
	<dc:identifier>10.15575/biodjati.v7i2.18616</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Biodjati; Vol. 7 No. 2 (2022): November; 280-291</dc:source>
	<dc:source xml:lang="id-ID">Jurnal Biodjati; Vol 7 No 2 (2022): November; 280-291</dc:source>
	<dc:source>2541-4208</dc:source>
	<dc:source>2548-1606</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinsgd.ac.id/index.php/biodjati/article/view/18616/7856</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Jurnal Biodjati</dc:rights>
</oai_dc:dc>