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Effect of Calina Papaya Leaves Extract on Respiratory Tract in Cigarette Smoke Exposed Rats

Jurnal Biodjati · Vol. 7 No. 2 (2022) · hlm. 189–198

DOI
10.15575/biodjati.v7i2.19068
ISSN
2541-4208, 2548-1606
Terbit
2022-11-30
Penerbit
UIN Sunan Gunung Djati Bandung
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-nd/4.0

Abstrak

Cigarette smoke is a source of free radicals that cause health problems throughout the world. Indonesia is a country that has many sources of natural antioxidants in counteracting free radicals, one of which is Calina papaya leaves. The study aimed to determine the potential of Calina papaya leaves antioxidants in improving the respiratory organs of Wistar rats after being exposed to cigarette smoke. The study using 25 male Wistar rats consisted of Control (not exposed to cigarette smoke and given distilled water), KN (cigarette smoke and given distilled water), P1 (cigarette smoke and Calina Papaya Leaves Ethanolic extracts (CPLE) 100 mg/kg BW), P2 (cigarette smoke and CPLE 200 mg/kg BW), and P3 (cigarette smoke and given CPLE 300 mg/kg BW). Exposure to cigarette smoke and administration of extracts was carried out for 21 days. On day 22, the rats were euthanized and dissected to remove the lungs and trachea. Organs were prepared using the paraffin method and hematoxylin-eosin staining. Parameters consisted of histopathological observations of the lungs and trachea. All data parameters were analyzed using a one-way ANOVA test and Duncan's advanced test (p<0.05). The results showed that there was an improvement in histopathology of the lungs and trachea at a dose of 200 mg/Kg BW compared to other doses (p<0.05). The study showed that the Calina papaya leaves ethanolic extracts have the potential as a source of antioxidants in improving the respiratory organs of Wistar rats after being exposed to cigarette smoke.

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  • Universitas Ahmad Dahlan
  • Universitas Jember
  • Universitas Gadjah Mada
  • Andalas University
  • IPB University
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  • Organisasi berbeda
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Rekan penulisOrganisasiArtikel bersama
Rizkyta J. NingrumUniversitas Ahmad Dahlan1
Aulia A. AzzahraUniversitas Ahmad Dahlan1
Nurul SuwartiningsihUniversitas Ahmad Dahlan1
Rita MalizaAndalas University1
Syaiful Adam MaulanaUniversitas Ahmad Dahlan1
Muhammad Ilham HisbullahUniversitas Ahmad Dahlan1
Andika Gundawa HidayatUniversitas Ahmad Dahlan1
Yumna NabilahUniversitas Ahmad Dahlan1
Diah Kartika WardaniUniversitas Ahmad Dahlan1
Ulinuha Farah MakhabatiUniversitas Ahmad Dahlan1
Pudjianto .Afiliasi tidak diketahui1
Nina MaryanaIPB University1
Wildan MuhlisonUniversitas Jember1
Irwanto SuciptoUniversitas Jember1
Ahmad TantowiUniversitas Jember1
Muhammad UsmanUniversitas Jember1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.uinsgd.ac.id/index.php/biodjati/oai, pertama di-harvest 7 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Effect of Calina Papaya Leaves Extract on Respiratory Tract in Cigarette Smoke Exposed Rats</dc:title>
	<dc:creator>Setiawan, Haris</dc:creator>
	<dc:creator>Hikmawati, Arlinda Sekar Ayu</dc:creator>
	<dc:creator>Wulandari, Sri Wijayanti</dc:creator>
	<dc:creator>Malinda, Eriza Via</dc:creator>
	<dc:creator>Putra, Ichsan Luqmana Indra</dc:creator>
	<dc:subject xml:lang="en-US">antioxidants</dc:subject>
	<dc:subject xml:lang="en-US">Calina papaya</dc:subject>
	<dc:subject xml:lang="en-US">ciggarette smoke</dc:subject>
	<dc:subject xml:lang="en-US">lung</dc:subject>
	<dc:subject xml:lang="en-US">trachea</dc:subject>
	<dc:description xml:lang="en-US">Cigarette smoke is a source of free radicals that cause health problems throughout the world. Indonesia is a country that has many sources of natural antioxidants in counteracting free radicals, one of which is Calina papaya leaves. The study aimed to determine the potential of Calina papaya leaves antioxidants in improving the respiratory organs of Wistar rats after being exposed to cigarette smoke. The study using 25 male Wistar rats consisted of Control (not exposed to cigarette smoke and given distilled water), KN (cigarette smoke and given distilled water), P1 (cigarette smoke and Calina Papaya Leaves Ethanolic extracts (CPLE) 100 mg/kg BW), P2 (cigarette smoke and CPLE 200 mg/kg BW), and P3 (cigarette smoke and given CPLE 300 mg/kg BW). Exposure to cigarette smoke and administration of extracts was carried out for 21 days. On day 22, the rats were euthanized and dissected to remove the lungs and trachea. Organs were prepared using the paraffin method and hematoxylin-eosin staining. Parameters consisted of histopathological observations of the lungs and trachea. All data parameters were analyzed using a one-way ANOVA test and Duncan's advanced test (p&amp;lt;0.05). The results showed that there was an improvement in histopathology of the lungs and trachea at a dose of 200 mg/Kg BW compared to other doses (p&amp;lt;0.05). The study showed that the Calina papaya leaves ethanolic extracts have the potential as a source of antioxidants in improving the respiratory organs of Wistar rats after being exposed to cigarette smoke.</dc:description>
	<dc:publisher xml:lang="en-US">UIN Sunan Gunung Djati Bandung</dc:publisher>
	<dc:date>2022-11-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.uinsgd.ac.id/index.php/biodjati/article/view/19068</dc:identifier>
	<dc:identifier>10.15575/biodjati.v7i2.19068</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Biodjati; Vol. 7 No. 2 (2022): November; 189-198</dc:source>
	<dc:source xml:lang="id-ID">Jurnal Biodjati; Vol 7 No 2 (2022): November; 189-198</dc:source>
	<dc:source>2541-4208</dc:source>
	<dc:source>2548-1606</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinsgd.ac.id/index.php/biodjati/article/view/19068/7830</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Jurnal Biodjati</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-nc-nd/4.0</dc:rights>
</oai_dc:dc>