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In Vitro Antioxidant and Anti-Obesity Activities of Ethanolic Extract from Microalgae Strain MRB-2

Jurnal Biodjati · Vol. 9 No. 1 (2024) · hlm. 1–10

DOI
10.15575/biodjati.v9i1.30385
ISSN
2541-4208, 2548-1606
Terbit
2024-05-31
Penerbit
UIN Sunan Gunung Djati Bandung
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-nd/4.0

Abstrak

Obesity has a 15-fold higher risk of coronary heart disease, stroke, and diabetes mellitus. Microalga isone of the natural resources that potentially treat obesity. The purpose of this study was to evaluate the total phenolic contents (TPC), antioxidant, and anti-obesity properties of ethanolic extract of microalgae strain MRB-2. The TPC was determined using the Follin-Ciocalteu method. The antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, and the anti-obesity was analyzed using an anti-lipase pancreatic assay. The morphology of microalga cells was also determined using Scanning Electron Microscopy (SEM). The results revealed that the TPC of ethanolic extract from the ultrasound extraction method was higher than the maceration method with the value of 2.75±0.26 mg GAE/g. While the scavenging activity toward DPPH radicals of ethanolic extract from the maceration method was higher than ultrasound, with a value of 38.92±1.94% at 0.8 mg/mL. The lipase inhibitory activity of extract from the maceration method was higher than ultrasound with a value of 20.81±2.24% at 0.38 mg/mL. Our results indicate that ethanolic extract of MRB-2 was potentially developed for anti-obesity foods and health-functional foods derived from new peatland microalgae.

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  • University of Brawijaya
  • National Research and Innovation Agency
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Rekan penulisOrganisasiArtikel bersama
Riris Istighfari JenieAfiliasi tidak diketahui6
Mohamad SyaefudinAfiliasi tidak diketahui4
Diah Vitri WidayantiAfiliasi tidak diketahui4
Ratna Asmah SusidartiAfiliasi tidak diketahui4
Neli PurwaniAfiliasi tidak diketahui3
Edy MeiyantoAfiliasi tidak diketahui3
Zalinar UdinAfiliasi tidak diketahui3
Dwi AstutiAfiliasi tidak diketahui2
Tri Eko AgustiningrumAfiliasi tidak diketahui2
Sudarwoto SudarwotoAfiliasi tidak diketahui2
Nurul YuhanafiaAfiliasi tidak diketahui2
Virgiawan Adi KristiantoAfiliasi tidak diketahui2
Aan KurniawanNational Research and Innovation Agency2
Syarifah NurainiAfiliasi tidak diketahui2
Ani Budi AstutiUniversity of Brawijaya1
Suci AstutikUniversity of Brawijaya1
Nur Silviyah RahmiUniversity of Brawijaya1
Alifiandi Rafi MuhammadUniversity of Brawijaya1
Ulfah MaisarohUniversity of Brawijaya1
Kismi MubarokahAfiliasi tidak diketahui1
Harianingsih HarianingsihAfiliasi tidak diketahui1
Maharani KusumaningrumAfiliasi tidak diketahui1
Vera Noviana SulistyawanAfiliasi tidak diketahui1
Savira Rinda ErlianaAfiliasi tidak diketahui1
Isnina Noor UbayAfiliasi tidak diketahui1
Indra Sakti PangestuAfiliasi tidak diketahui1
Nur QudusAfiliasi tidak diketahui1
Nelly Setyowati AnggraeniAfiliasi tidak diketahui1
Ade Novi Nurul IhsaniAfiliasi tidak diketahui1
Delta ApriyaniAfiliasi tidak diketahui1
Sri Endah WahyuningsihAfiliasi tidak diketahui1
Ana MaryanaAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.uinsgd.ac.id/index.php/biodjati/oai, pertama di-harvest 7 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">In Vitro Antioxidant and Anti-Obesity Activities of Ethanolic Extract from Microalgae Strain MRB-2</dc:title>
	<dc:creator>Ni’maturrohmah, Dwi</dc:creator>
	<dc:creator>Darsih, Cici</dc:creator>
	<dc:creator>Susanti, Hani</dc:creator>
	<dc:creator>Hidhayati, Noor</dc:creator>
	<dc:creator>Indrianingsih, Anastasia Wheni</dc:creator>
	<dc:creator>Handayani, Sri</dc:creator>
	<dc:creator>Hasby, Rizal Maulana</dc:creator>
	<dc:creator>Laksitorini, Marlyn Dian</dc:creator>
	<dc:subject xml:lang="en-US">Anti-obesity</dc:subject>
	<dc:subject xml:lang="en-US">antioxidant</dc:subject>
	<dc:subject xml:lang="en-US">microalgae</dc:subject>
	<dc:subject xml:lang="en-US">total phenolic</dc:subject>
	<dc:subject xml:lang="en-US">peatland microalgae</dc:subject>
	<dc:description xml:lang="en-US">Obesity has a 15-fold higher risk of coronary heart disease, stroke, and diabetes mellitus. Microalga isone of the natural resources that potentially treat obesity. The purpose of this study was to evaluate the total phenolic contents (TPC), antioxidant, and anti-obesity properties of ethanolic extract of microalgae strain MRB-2. The TPC was determined using the Follin-Ciocalteu method. The antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, and the anti-obesity was analyzed using an anti-lipase pancreatic assay. The morphology of microalga cells was also determined using Scanning Electron Microscopy (SEM). The results revealed that the TPC of ethanolic extract from the ultrasound extraction method was higher than the maceration method with the value of 2.75±0.26 mg GAE/g. While the scavenging activity toward DPPH radicals of ethanolic extract from the maceration method was higher than ultrasound, with a value of 38.92±1.94% at 0.8 mg/mL. The lipase inhibitory activity of extract from the maceration method was higher than ultrasound with a value of 20.81±2.24% at 0.38 mg/mL. Our results indicate that ethanolic extract of MRB-2 was potentially developed for anti-obesity foods and health-functional foods derived from new peatland microalgae.</dc:description>
	<dc:publisher xml:lang="en-US">UIN Sunan Gunung Djati Bandung</dc:publisher>
	<dc:date>2024-05-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.uinsgd.ac.id/index.php/biodjati/article/view/30385</dc:identifier>
	<dc:identifier>10.15575/biodjati.v9i1.30385</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Biodjati; Vol. 9 No. 1 (2024): May; 1-10</dc:source>
	<dc:source xml:lang="id-ID">Jurnal Biodjati; Vol 9 No 1 (2024): May; 1-10</dc:source>
	<dc:source>2541-4208</dc:source>
	<dc:source>2548-1606</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinsgd.ac.id/index.php/biodjati/article/view/30385/10755</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 Jurnal Biodjati</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-nc-nd/4.0</dc:rights>
</oai_dc:dc>