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The Effects of Pasak Bumi (Eurycoma Longifolia Jack) Product on Liver Histology of Wader Pari (Rasbora Lateristriata Bleeker, 1854)

Jurnal Biodjati · Vol. 11 No. 1 (2026) · hlm. 52–63

DOI
10.15575/biodjati.v11i1.47944
ISSN
2541-4208, 2548-1606
Terbit
2026-05-31
Penerbit
UIN Sunan Gunung Djati Bandung
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-nd/4.0

Abstrak

Eurycoma longifolia Jack (commonly known as pasak bumi) is a medicinal plant that contains various bioactive compounds such as eurycomanone, saponins, sterols, and isoprenoids, which are known to exert multiple physiological effects, including on the liver as an organ. This study aimed to examine the effects of pasak bumi root product on liver histology in yellow rasbora (Rasbora lateristriata) as an animal model and to compare the effects between continuous and cyclic (5 days ON, 2 days OFF) administration methods. The experiment lasted 2 weeks, with three treatment groups: control (no extract), continuous administration (P1), and cyclic administration (P2). Observed parameters included liver tissue structure, such as the central vein and hepatocytes arrangement, as well as histological features of hepatocytes. Data were analyzed using one-way ANOVA followed by Duncan’s test. The results showed that pasak bumi administration affected the histological structure of the liver in R. lateristriata, with observable cellular damage including pyknosis, karyorrhexis, and necrosis. Continuous treatment (P2) caused more severe damage than cyclic treatment (P1), which showed tissue structures more similar to those of the control group. Therefore, cyclic administration is considered safer and tends to induce milder liver damage in fish than continuous administration

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19 penulis · 39 tautan kepenulisan bersama · 11 lintas organisasi

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  • Universitas Gadjah Mada
  • Jenderal Soedirman University
  • Universitas Al-Azhar Indonesia
  • Hasanuddin University
  • Tohoku University
  • National Research and Innovation Agency
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
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Rekan penulisOrganisasiArtikel bersama
Pradnya ParamitaUniversitas Gadjah Mada2
Luthfia Uswatun KhasanahUniversitas Gadjah Mada2
Selvi AriyunitaUniversitas Gadjah Mada1
Suwarno HadisusantoUniversitas Gadjah Mada1
Andhika Puspito NugrohoUniversitas Gadjah Mada1
Endah Sri PalupiJenderal Soedirman University1
Firman AlamsyahUniversitas Al-Azhar Indonesia1
Rarastoeti PratiwiUniversitas Gadjah Mada1
Warsito Purwo TarunoAfiliasi tidak diketahui1
PUDJI ASTUTIAfiliasi tidak diketahui1
Nastiti WijayantiUniversitas Gadjah Mada1
Laili Mufli ZusrinaUniversitas Gadjah Mada1
Slamet WidiyantoUniversitas Gadjah Mada1
Juniman ReyUniversitas Gadjah Mada1
Sih KahonoNational Research and Innovation Agency1
Andi Gita Maulidyah Indraswari SuhriHasanuddin University1
Yusdar MustaminTohoku University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.uinsgd.ac.id/index.php/biodjati/oai, pertama di-harvest 7 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">The Effects of Pasak Bumi (Eurycoma Longifolia Jack) Product on Liver Histology of Wader Pari (Rasbora Lateristriata Bleeker, 1854)</dc:title>
	<dc:creator>Jihan Restu Buana</dc:creator>
	<dc:creator>Retnoaji, Bambang</dc:creator>
	<dc:subject xml:lang="en-US">continuous</dc:subject>
	<dc:subject xml:lang="en-US">cyclic</dc:subject>
	<dc:subject xml:lang="en-US">Eurycoma longifolia</dc:subject>
	<dc:subject xml:lang="en-US">liver</dc:subject>
	<dc:subject xml:lang="en-US">Rasbora lateristriata</dc:subject>
	<dc:description xml:lang="en-US">Eurycoma longifolia Jack (commonly known as pasak bumi) is a medicinal plant that contains various bioactive compounds such as eurycomanone, saponins, sterols, and isoprenoids, which are known to exert multiple physiological effects, including on the liver as an organ. This study aimed to examine the effects of pasak bumi root product on liver histology in yellow rasbora (Rasbora lateristriata) as an animal model and to compare the effects between continuous and cyclic (5 days ON, 2 days OFF) administration methods. The experiment lasted 2 weeks, with three treatment groups: control (no extract), continuous administration (P1), and cyclic administration (P2). Observed parameters included liver tissue structure, such as the central vein and hepatocytes arrangement, as well as histological features of hepatocytes. Data were analyzed using one-way ANOVA followed by Duncan’s test. The results showed that pasak bumi administration affected the histological structure of the liver in R. lateristriata, with observable cellular damage including pyknosis, karyorrhexis, and necrosis. Continuous treatment (P2) caused more severe damage than cyclic treatment (P1), which showed tissue structures more similar to those of the control group. Therefore, cyclic administration is considered safer and tends to induce milder liver damage in fish than continuous administration</dc:description>
	<dc:publisher xml:lang="en-US">UIN Sunan Gunung Djati Bandung</dc:publisher>
	<dc:date>2026-05-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.uinsgd.ac.id/index.php/biodjati/article/view/47944</dc:identifier>
	<dc:identifier>10.15575/biodjati.v11i1.47944</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Biodjati; Vol. 11 No. 1 (2026): May; 52-63</dc:source>
	<dc:source xml:lang="id-ID">Jurnal Biodjati; Vol 11 No 1 (2026): May; 52-63</dc:source>
	<dc:source>2541-4208</dc:source>
	<dc:source>2548-1606</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinsgd.ac.id/index.php/biodjati/article/view/47944/16498</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2026 Jurnal Biodjati</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-nc-nd/4.0</dc:rights>
</oai_dc:dc>