Hemostatic Status of Pre and Post Intracoronary Injection of Peripheral Blood Stem Cells in Patients with Recent Myocardial Infarction

Irawan, Cosphiadi; Santoso, Teguh; Atmakusumah, Djumhana; Alwi, Idrus; Kosasih, Agus; Aziz, Auda; Abdulmuthalib, Abdulmuthalib; Lyana, Lyana; Inggriani, Sri; Saputra, Ardian; Wintery, Merry; Lison, Linda; Reksodiputro, Ary H; Sudoyo, Aru W

Jurnal SINTA 1

Hemostatic Status of Pre and Post Intracoronary Injection of Peripheral Blood Stem Cells in Patients with Recent Myocardial Infarction

ACTA MEDICA INDONESIANA · Vol. 46 No. 1 (2016)

ISSN: 2338-2732, 0125-9326
Terbit: 2016-05-16
Penerbit: The Indonesian Society of Internal Medicine
Bahasa: eng

Abstrak

Aim: to investigate hemostatic parameter changes, such as platelet aggregation, blood and plasma viscosity, prothrombin time, APTT, CRP and fibrinogen, before and after administration of stem cell therapy. Methods: a total of 24 patients were enrolled. Peripheral blood stem cells (PBSCs) were harvested and injected into the infarct-related artery after 5 consecutive days of G-CSF administration. Recombinant human erythropoietin was administered at the time of intracoronary PBSCs injection. Results: we were able to evaluate 11 from 24 of patients regarding hemostatic status pre–post stem cell injection. There were no significant difference between baseline vs 3 months in spontaneous aggregation (p=0.350), PT (p=0.793), aPTT (p=0.255) and TT (p=0.254). There were also no significant difference between baseline vs 3 months in plasma viscosity (p=0.442) and blood viscosity (p=0.843). Nevertheless the patient who had their blood and plasma viscosity above or below normal laboratory range return to normal level after the treatment. Both PT and APTT also show normalization value. Both Fibrinogen and CRP level show significant decrease between baseline and 3 months after treatment (p=0.009) and (p=0.04) respectively. Conclusion: combined G-CSF and EPO based-intracoronary infusion of PBSCs may open new perspective in the treatment of hypercoagulable state post AMI. Key words: coagulation, platelet aggregation, myocardial infarction, hypercoagulation

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Rekan penulis	Organisasi	Artikel bersama
Kuntjoro Harimurti	Afiliasi tidak diketahui	8
Hamzah Shatri	Afiliasi tidak diketahui	6
Muchtaruddin Mansyur	Afiliasi tidak diketahui	5
Eka Ginanjar	Afiliasi tidak diketahui	4
Rudi Putranto	Afiliasi tidak diketahui	4
Militcyano Samuel Sapulette	Australian National University	3
Muhammad Yamin	Afiliasi tidak diketahui	3
Taufik Indrajaya	Afiliasi tidak diketahui	3
Rahmat Cahyanur	Afiliasi tidak diketahui	3
Arif Mansjoer	Afiliasi tidak diketahui	3
Ika P Wijaya	Afiliasi tidak diketahui	3
Suhendro Suhendro	Afiliasi tidak diketahui	3
Em Yunir	University of Indonesia	3
Siti Setiati	Afiliasi tidak diketahui	2
Simon Salim	Afiliasi tidak diketahui	2
Suzanna Immanuel	Afiliasi tidak diketahui	2
Aida Lydia	Afiliasi tidak diketahui	2
Mizanul Adli	Afiliasi tidak diketahui	2
Dina Elita	Afiliasi tidak diketahui	2
Ratih Arianita Agung	Afiliasi tidak diketahui	2
Lisnawati Lisnawati	Afiliasi tidak diketahui	2
Sally Aman Nasution	Afiliasi tidak diketahui	2
Andhika Rachman	Afiliasi tidak diketahui	2
Murdani Abdullah	Afiliasi tidak diketahui	2
Vera Abdullah	Afiliasi tidak diketahui	2
Imam Subekti	Afiliasi tidak diketahui	2

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Metadata asli (oai_dc)

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	<dc:title xml:lang="en-US">Hemostatic Status of Pre and Post Intracoronary Injection of Peripheral Blood Stem Cells in Patients with Recent Myocardial Infarction</dc:title>
	<dc:creator>Irawan, Cosphiadi</dc:creator>
	<dc:creator>Santoso, Teguh</dc:creator>
	<dc:creator>Atmakusumah, Djumhana</dc:creator>
	<dc:creator>Alwi, Idrus</dc:creator>
	<dc:creator>Kosasih, Agus</dc:creator>
	<dc:creator>Aziz, Auda</dc:creator>
	<dc:creator>Abdulmuthalib, Abdulmuthalib</dc:creator>
	<dc:creator>Lyana, Lyana</dc:creator>
	<dc:creator>Inggriani, Sri</dc:creator>
	<dc:creator>Saputra, Ardian</dc:creator>
	<dc:creator>Wintery, Merry</dc:creator>
	<dc:creator>Lison, Linda</dc:creator>
	<dc:creator>Reksodiputro, Ary H</dc:creator>
	<dc:creator>Sudoyo, Aru W</dc:creator>
	<dc:description xml:lang="en-US">Aim: to investigate hemostatic parameter changes, such as platelet aggregation, blood and plasma viscosity, prothrombin time, APTT, CRP and fibrinogen, before and after administration of stem cell therapy. Methods: a total of 24 patients were enrolled. Peripheral blood stem cells (PBSCs) were harvested and injected into the infarct-related artery after 5 consecutive days of G-CSF administration. Recombinant human erythropoietin was administered at the time of intracoronary PBSCs injection. Results: we were able to evaluate 11 from 24 of patients regarding hemostatic status pre–post stem cell injection. There were no significant difference between baseline vs 3 months in spontaneous aggregation (p=0.350), PT (p=0.793), aPTT (p=0.255) and TT (p=0.254). There were also no significant difference between baseline vs 3 months in plasma viscosity (p=0.442) and blood viscosity (p=0.843). Nevertheless the patient who had their blood and plasma viscosity above or below normal laboratory range return to normal level after the treatment. Both PT and APTT also show normalization value. Both Fibrinogen and CRP level show significant decrease between baseline and 3 months after treatment (p=0.009) and (p=0.04) respectively. Conclusion: combined G-CSF and EPO based-intracoronary infusion of PBSCs may open new perspective in the treatment of hypercoagulable state post AMI. Key words: coagulation, platelet aggregation, myocardial infarction, hypercoagulation</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2016-05-16</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/58</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 46 No. 1 (2014)</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/58/54</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2016 Indonesian Journal of internal Medicine</dc:rights>
</oai_dc:dc>