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Predictors of Five Days Mortality in Diabetic Ketoacidosis Patients: a Prospective Cohort Study

ACTA MEDICA INDONESIANA · Vol. 46 No. 1 (2014)

ISSN
2338-2732, 0125-9326
Terbit
2014-01-01
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Aim: to determine the role of serum lactate and diabetic ketoacidosis (DKA) severity as predictors for five-days mortality in DKA patients. Methods: a prospective cohort study was conducted in DKA patients admitted to emergency department (ED) at Cipto Mangunkusumo Hospital, Jakarta, Indonesia, during 2007-2008 periods. Predictors for 5 days mortality in DKA patients in this study including serum lactate and DKA severity (plasma glucose, arterial blood pH, serum bicarbonate, osmolality, anion gap, and alteration in sensorium) at admission. Cox’s Proportional Hazard Regression Analysis was used to determine independent predictors for 5-days mortality among study population. Results: sixty patients with diabetic ketoacidosis were enrolled in the study; in which 24 (40%) patients were died within 5 days after admission. In the multivariate analysis, the lactate level ≥4 mmol/L (HR, 3.09; 95% CI, 1.36-7.05) and altered in sensorium stuporous/comatose (HR, 3.38; 95% CI, 1.45-7.87) were identified as independent predictors for 5-days mortality in DKA adult patients. Conclusion: lactate level ≥4 mmol/L and altered in sensorium stuporous/comatose can be used to predict 5-days mortality in adult patients with DKA. Key words: diabetic ketoacidosis, sepsis, lactate level, alteration in sensorium mortality.

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  • University of Indonesia
  • Joint United Nations Programme on HIV/AIDS
  • Kementerian Kesehatan Republik Indonesia
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  • Organisasi berbeda
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Rekan penulisOrganisasiArtikel bersama
Kuntjoro HarimurtiAfiliasi tidak diketahui4
Idrus AlwiAfiliasi tidak diketahui3
Erni J NelwanAfiliasi tidak diketahui2
Hamzah ShatriAfiliasi tidak diketahui2
Rudi PutrantoAfiliasi tidak diketahui2
Pradana SoewondoAfiliasi tidak diketahui2
Suzanna ImmanuelAfiliasi tidak diketahui2
Em YunirUniversity of Indonesia2
Lely WahyuniarJoint United Nations Programme on HIV/AIDS1
Abas B. DjauhariKementerian Kesehatan Republik Indonesia1
Ratna DjuwitaUniversity of Indonesia1
Lukman H MakmunAfiliasi tidak diketahui1
Alida R HarahapAfiliasi tidak diketahui1
Slamet SuyonoAfiliasi tidak diketahui1
Mpu Kanoko SastrosuwignyoAfiliasi tidak diketahui1
Robert SintoAfiliasi tidak diketahui1
Djoko WidodoAfiliasi tidak diketahui1
Tonny LohoAfiliasi tidak diketahui1
Rahajuningsih D SetiabudyAfiliasi tidak diketahui1
Venna VennaAfiliasi tidak diketahui1
Ninik SukartiniAfiliasi tidak diketahui1
July KumalawatiAfiliasi tidak diketahui1
Andi A VictorAfiliasi tidak diketahui1
Rino A GaniAfiliasi tidak diketahui1
Irsan HasanAfiliasi tidak diketahui1
Laurentius A LesmanaAfiliasi tidak diketahui1
Jacub PandelakiAfiliasi tidak diketahui1
Siti B KresnoAfiliasi tidak diketahui1
Saptawati BardosonoAfiliasi tidak diketahui1
Ronald Winardi KartikaAfiliasi tidak diketahui1
Franciscus D SuyatnaAfiliasi tidak diketahui1
Suzana ImmanuelAfiliasi tidak diketahui1
Saleha SungkarAfiliasi tidak diketahui1
Jusuf RachmatAfiliasi tidak diketahui1
Mirta HediyatiAfiliasi tidak diketahui1
Todung SilalahiAfiliasi tidak diketahui1

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Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Predictors of Five Days Mortality in Diabetic Ketoacidosis Patients: a Prospective Cohort Study</dc:title>
	<dc:creator>Suwarto, Suhendro</dc:creator>
	<dc:creator>Sutrisna, Bambang</dc:creator>
	<dc:creator>Waspadji, Sarwono</dc:creator>
	<dc:creator>Pohan, Herdiman T</dc:creator>
	<dc:description xml:lang="en-US">Aim: to determine the role of serum lactate and diabetic ketoacidosis (DKA) severity as predictors for five-days mortality in DKA patients. Methods: a prospective cohort study was conducted in DKA patients admitted to emergency department (ED) at Cipto Mangunkusumo Hospital, Jakarta, Indonesia, during 2007-2008 periods. Predictors for 5 days mortality in DKA patients in this study including serum lactate and DKA severity (plasma glucose, arterial blood pH, serum bicarbonate, osmolality, anion gap, and alteration in sensorium) at admission. Cox’s Proportional Hazard Regression Analysis was used to determine independent predictors for 5-days mortality among study population. Results: sixty patients with diabetic ketoacidosis were enrolled in the study; in which 24 (40%) patients were died within 5 days after admission. In the multivariate analysis, the lactate level ≥4 mmol/L (HR, 3.09; 95% CI, 1.36-7.05) and altered in sensorium stuporous/comatose (HR, 3.38; 95% CI, 1.45-7.87) were identified as independent predictors for 5-days mortality in DKA adult patients. Conclusion: lactate level ≥4 mmol/L and altered in sensorium stuporous/comatose can be used to predict 5-days mortality in adult patients with DKA. Key words: diabetic ketoacidosis, sepsis, lactate level, alteration in sensorium mortality.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2014-01-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/59</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 46 No. 1 (2014)</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/59/55</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2016 Indonesian Journal of internal Medicine</dc:rights>
</oai_dc:dc>