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Profile of PRMT-1 Gene Polymorphism in Hemodialysis Patients with Increased ADMA Levels

ACTA MEDICA INDONESIANA · Vol. 46 No. 2 (2016)

ISSN
2338-2732, 0125-9326
Terbit
2016-05-16
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Aim: to determine the distribution of PRMT-1 gene polymorphism and ADMA levels among continuing hemodialysis patients. Methods: genotyping of PRMT-1 polymorphism was performed in 57 hemodialysis patients at Al Irsjad Hospital. All participants were recruited for physical examination, questionnaire, and collection of 5 mL fasting venous blood. The blood was treated with phenol-chloroform extraction of genomic DNA. The candidate’s single nucleotide polymorphisms (SNPs) were genotyped by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The ADMA plasma levels was determined by ELISA and all biochemical indicators of serum were examined. Results: fifty-seven hemodialysis patients participated in our study, 54 (95.4%) of them had increased ADMA plasma levels. DNA sequencing analysis of 13 patients showed a suspected PRMT-1 gene polymorphism at sequence 5837 as there were different genotypes between C and G. Conclusion: the increased levels of ADMA might be caused by PRMT-1 gene polymorphism.Key words: ADMA, PRMT-1 polymorphism, chronic kidney disease

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  • University of Singaperbangsa Karawang
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Syaiful AminAfiliasi tidak diketahui1
Avi Budi SetiawanAfiliasi tidak diketahui1
Wahyu Ananda PutriAfiliasi tidak diketahui1
Abdul HadiUniversity of Singaperbangsa Karawang1
Nurul AfifahAfiliasi tidak diketahui1
Indra JayaAfiliasi tidak diketahui1
Fajar AfriantoAfiliasi tidak diketahui1
Roma AprihenAfiliasi tidak diketahui1
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Hanif Naufal ZuhdiAfiliasi tidak diketahui1
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Sindy KiraraAfiliasi tidak diketahui1
Mella AstikaAfiliasi tidak diketahui1
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Muhammad AliAfiliasi tidak diketahui1
Alisia Y PutriAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Profile of PRMT-1 Gene Polymorphism in Hemodialysis Patients with Increased ADMA Levels</dc:title>
	<dc:creator>Thaha, Mochammad</dc:creator>
	<dc:creator>Nilamsari, Wenny P</dc:creator>
	<dc:creator>Yusuf, Mochammad</dc:creator>
	<dc:creator>Amin, M.</dc:creator>
	<dc:description xml:lang="en-US">Aim: to determine the distribution of PRMT-1 gene polymorphism and ADMA levels among continuing hemodialysis patients. Methods: genotyping of PRMT-1 polymorphism was performed in 57 hemodialysis patients at Al Irsjad Hospital. All participants were recruited for physical examination, questionnaire, and collection of 5 mL fasting venous blood. The blood was treated with phenol-chloroform extraction of genomic DNA. The candidate’s single nucleotide polymorphisms (SNPs) were genotyped by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The ADMA plasma levels was determined by ELISA and all biochemical indicators of serum were examined. Results: fifty-seven hemodialysis patients participated in our study, 54 (95.4%) of them had increased ADMA plasma levels. DNA sequencing analysis of 13 patients showed a suspected PRMT-1 gene polymorphism at sequence 5837 as there were different genotypes between C and G. Conclusion: the increased levels of ADMA might be caused by PRMT-1 gene polymorphism.Key words: ADMA, PRMT-1 polymorphism, chronic kidney disease</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2016-05-16</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/74</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 46 No. 2 (2014)</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/74/70</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2016 Indonesian Journal of internal Medicine</dc:rights>
</oai_dc:dc>