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Relationship between Metformin and Frailty Syndrome in Elderly People with Type 2 Diabetes

ACTA MEDICA INDONESIANA · Vol. 46 No. 3 (2016)

ISSN
2338-2732, 0125-9326
Terbit
2016-05-16
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Aim: to explore the possibility of metformin protective effect on frailty syndrome. Methods: this was a case control study conducted in subjects’ ≥60 years old who visited the Geriatrics and Diabetes outpatient clinic of Cipto Mangunkusumo National Referral Hospital between March and June 2013. Diagnosis of frailty was established using the FI-40 item criteria. Statistical analysis was done with chi-square method for bivariate and logistic regression method in multivariate analysis, all data was accompanied with 95% confidence interval. Results: frailty syndrome was found in 25% of subjects (n=59), with median age of 72 years old (SD 6.27) and median of FI-40 item score was 0.18 (SD 0.085). Metformin was found to have a significant relationship with frailty syndrome in the elderly diabetics, which retained significant value after multivariate analysis (adjusted OR 0.043; 95% CI 0.019-0.099; p<0.001). Conclusion: metformin was shown to have protective effect against frailty syndrome in elderly diabetics. Key words: frailty, diabetes mellitus, metformin, elderly.

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Hamzah ShatriAfiliasi tidak diketahui8
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Tirza Z TaminAfiliasi tidak diketahui4
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Sally Aman NasutionAfiliasi tidak diketahui4
Purwita W LaksmiAfiliasi tidak diketahui3
Ari Fahrial SyamAfiliasi tidak diketahui3
Muhammad YaminInstitut Agama Islam Negeri Bone3
Simon SalimAfiliasi tidak diketahui3
Eric Daniel TendaAfiliasi tidak diketahui3
Muhammad K AzwarAfiliasi tidak diketahui3
Ika FitrianaHasanuddin University3
Em YunirUniversity of Indonesia3
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Dante Saksono HarbuwonoAfiliasi tidak diketahui3
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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Relationship between Metformin and Frailty Syndrome in Elderly People with Type 2 Diabetes</dc:title>
	<dc:creator>Sumantri, Stevent</dc:creator>
	<dc:creator>Setiati, Siti</dc:creator>
	<dc:creator>Purnamasari, Dyah</dc:creator>
	<dc:creator>Dewiasty, Esthika</dc:creator>
	<dc:description xml:lang="en-US">Aim: to explore the possibility of metformin protective effect on frailty syndrome. Methods: this was a case control study conducted in subjects’ ≥60 years old who visited the Geriatrics and Diabetes outpatient clinic of Cipto Mangunkusumo National Referral Hospital between March and June 2013. Diagnosis of frailty was established using the FI-40 item criteria. Statistical analysis was done with chi-square method for bivariate and logistic regression method in multivariate analysis, all data was accompanied with 95% confidence interval. Results: frailty syndrome was found in 25% of subjects (n=59), with median age of 72 years old (SD 6.27) and median of FI-40 item score was 0.18 (SD 0.085). Metformin was found to have a significant relationship with frailty syndrome in the elderly diabetics, which retained significant value after multivariate analysis (adjusted OR 0.043; 95% CI 0.019-0.099; p&amp;lt;0.001). Conclusion: metformin was shown to have protective effect against frailty syndrome in elderly diabetics. Key words: frailty, diabetes mellitus, metformin, elderly.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2016-05-16</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/87</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 46 No. 3 (2014)</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/87/83</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2016 Indonesian Journal of internal Medicine</dc:rights>
</oai_dc:dc>