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Immune Response of Thalassemia Major Patients in Indonesia with and without Splenectomy

ACTA MEDICA INDONESIANA · Vol. 46 No. 3 (2016)

ISSN
2338-2732, 0125-9326
Terbit
2016-05-16
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Aim: to describe non-spesific and specific immune response profile in Indonesian thalassemia major with and without splenectomy. Methods: this study was held at Thalassaemia Centre, Cipto Mangunkusumo Hospital Jakarta on September 2013 – February 2014. A comparative cross sectional study was conducted in healthy, thalassemia major aged more than 12 year and seronegative HIV. They were matched in age and sex for splenectomised and non-splenectomised groups, analysing the non-spesific immune response (neutrophil count and phagocytosis) and specific immune response (count and function of cellular immunity). Infection episodes were also analized as immune response in vivo parameter. Results: splenectomised thalassemia major showed increased neutrophil count but significantly decreased non-spesific immune response (neutrophil phagocytosis). Spesific immune response of splenectomised group presented significantly higher absolute lymphocyte, lymphocyte T, CD4+ and CD8+ counts compared to non-splenectomised thalassemia major (p<0.05). Ratio CD4+/CD8+ were similar in these groups. Serum marker of activated cellular imunity function (IL-2 and TNF-α) were similar among two groups. Mild infection episodes on splenectomised and non-splenectomised group were 2.02 (ranged 0 to 12) times and 0.81 (ranged 0 to 8) times (p=0.004), respectively. Severe infection on splenectomised group were sepsis for 2 weeks and diarrhea for 1 week, whereas on non-splenectomised group was typhoid fever for 4 days. Conclusion: there were significant differences on immune response among thalassemia major patients. Splenectomised thalassemia major showed a greater degree of susceptibility to infections than non-splenectomised thalassemia major. Key words: immune response, thalassemia major, splenectomy.

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Andri Maruli T LubisAfiliasi tidak diketahui1
Kurniadi HusodoAfiliasi tidak diketahui1
Lugyanti SukrismanAfiliasi tidak diketahui1
Soedjatmiko SoedjatmikoState University of Semarang1
Hartono GunardiAfiliasi tidak diketahui1
Liza F ZaimiAfiliasi tidak diketahui1
Turyadi TuryadiAfiliasi tidak diketahui1
David H MuljonoAfiliasi tidak diketahui1
Bambang SutrisnaUniversity of Indonesia1
Pradana SoewondoAfiliasi tidak diketahui1
Lukman H MakmunAfiliasi tidak diketahui1
Slamet SuyonoAfiliasi tidak diketahui1
Mpu Kanoko SastrosuwignyoAfiliasi tidak diketahui1
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Endang SusalitAfiliasi tidak diketahui1
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Em YunirUniversity of Indonesia1
Idrus AlwiAfiliasi tidak diketahui1
Sarwono WaspadjiAfiliasi tidak diketahui1
Ronald Winardi KartikaAfiliasi tidak diketahui1
Franciscus D SuyatnaAfiliasi tidak diketahui1
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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Immune Response of Thalassemia Major Patients in Indonesia with and without Splenectomy</dc:title>
	<dc:creator>Sari1, Teny T</dc:creator>
	<dc:creator>Gatot, Djajadiman</dc:creator>
	<dc:creator>Akib, Arwin A.P.</dc:creator>
	<dc:creator>Bardosono, Saptawati</dc:creator>
	<dc:creator>Hadinegoro, Sri R.S.</dc:creator>
	<dc:creator>Harahap, Alida R</dc:creator>
	<dc:creator>Idjradinata, Ponpon S</dc:creator>
	<dc:description xml:lang="en-US">Aim: to describe non-spesific and specific immune response profile in Indonesian thalassemia major with and without splenectomy. Methods: this study was held at Thalassaemia Centre, Cipto Mangunkusumo Hospital Jakarta on September 2013 – February 2014. A comparative cross sectional study was conducted in healthy, thalassemia major aged more than 12 year and seronegative HIV. They were matched in age and sex for splenectomised and non-splenectomised groups, analysing the non-spesific immune response (neutrophil count and phagocytosis) and specific immune response (count and function of cellular immunity). Infection episodes were also analized as immune response in vivo parameter. Results: splenectomised thalassemia major showed increased neutrophil count but significantly decreased non-spesific immune response (neutrophil phagocytosis). Spesific immune response of splenectomised group presented significantly higher absolute lymphocyte, lymphocyte T, CD4+ and CD8+ counts compared to non-splenectomised thalassemia major (p&amp;lt;0.05). Ratio CD4+/CD8+ were similar in these groups. Serum marker of activated cellular imunity function (IL-2 and TNF-α) were similar among two groups. Mild infection episodes on splenectomised and non-splenectomised group were 2.02 (ranged 0 to 12) times and 0.81 (ranged 0 to 8) times (p=0.004), respectively. Severe infection on splenectomised group were sepsis for 2 weeks and diarrhea for 1 week, whereas on non-splenectomised group was typhoid fever for 4 days. Conclusion: there were significant differences on immune response among thalassemia major patients. Splenectomised thalassemia major showed a greater degree of susceptibility to infections than non-splenectomised thalassemia major. Key words: immune response, thalassemia major, splenectomy.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2016-05-16</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/91</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 46 No. 3 (2014)</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/91/87</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2016 Indonesian Journal of internal Medicine</dc:rights>
</oai_dc:dc>