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Effect of Metformin on Handgrip Strength, Gait Speed, Myostatin Serum Level, and Health-related Quality of Life: A Double Blind Randomized Controlled Trial among Non-diabetic Pre-frail Elderly Patients

ACTA MEDICA INDONESIANA · Vol. 49 No. 2 (2017)

ISSN
2338-2732, 0125-9326
Terbit
2017-08-08
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: sarcopenia contributes to the development of frailty syndrome. Frailty syndrome is potentially improved by modifying insulin resistance, inflammation, and myostatin level. This study is aimed to investigate the effect of metformin on handgrip strength, gait speed, myostatin serum level, and health-related quality of life (HR-QoL) among non-diabetic pre-frail elderly patients. Methods: a double blind randomized controlled trial study was conducted on non-diabetic elderly outpatients aged ≥ 60 years with pre-frail status based on phenotype and/ or index criteria (Cardiovascular Health Study and/ or Frailty Index 40 items) consecutively recruited from March 2015 to June 2016 at Cipto Mangunkusumo Hospital. One-hundred-twenty subjects who met the research criteria were randomized and equally assigned into 3 x 500 mg metformin or placebo group. The study outcomes were measured at baseline and after 16 weeks of intervention. Results: out of 120 subjects, 43 subjects in metformin group and 48 subjects in placebo group who completed the intervention. There was a significant improvement on the mean gait speed of metformin group by 0.39 (0.77) second or 0.13 (0.24) meter/second that remained significant after adjusting for important prognostic factors (p = 0.024). There was no significant difference on handgrip strength, myostatin serum level, and HR-QoL between both groups. Conclusion: 3 x 500 mg metformin for 16 weeks was statistically significant and clinically important in improving usual gait speed as one of the HR-QoL dimensions, but did not significantly improve the EQ-5D index score, handgrip strength, nor myostatin serum level.

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Kuntjoro HarimurtiAfiliasi tidak diketahui15
Hamzah ShatriAfiliasi tidak diketahui9
Noto DwimartutieAfiliasi tidak diketahui8
Dyah PurnamasariAfiliasi tidak diketahui8
Muhammad Khifzhon AzwarAfiliasi tidak diketahui7
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Roza MulyanaAfiliasi tidak diketahui5
Rensa RensaAfiliasi tidak diketahui5
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Rudi PutrantoAfiliasi tidak diketahui5
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Imam SubektiAfiliasi tidak diketahui5
Nur RiviatiAfiliasi tidak diketahui4
Aulia RizkaAfiliasi tidak diketahui4
Cleopas Martin RumendeAfiliasi tidak diketahui4
Eka Dian SafitriAfiliasi tidak diketahui4
Siti Rizny F SaldiAfiliasi tidak diketahui4
Purwita W LaksmiAfiliasi tidak diketahui4
Esthika DewiastyAfiliasi tidak diketahui4
Harry IsbagioAfiliasi tidak diketahui4
Idrus AlwiAfiliasi tidak diketahui4
Juferdy KurniawanAfiliasi tidak diketahui4
Ari Fahrial SyamAfiliasi tidak diketahui3
Muhammad YaminInstitut Agama Islam Negeri Bone3
Simon SalimAfiliasi tidak diketahui3
Eric Daniel TendaAfiliasi tidak diketahui3
Muhammad K AzwarAfiliasi tidak diketahui3
Ika FitrianaHasanuddin University3
Em YunirUniversity of Indonesia3
Iris RengganisAfiliasi tidak diketahui3
Dicky Levenus TahaparyAfiliasi tidak diketahui3
Samsuridjal DjauziAfiliasi tidak diketahui3

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Effect of Metformin on Handgrip Strength, Gait Speed, Myostatin Serum Level, and Health-related Quality of Life: A Double Blind Randomized Controlled Trial among Non-diabetic Pre-frail Elderly Patients</dc:title>
	<dc:creator>Laksmi, Purwita Wijaya</dc:creator>
	<dc:creator>Setiati, Siti</dc:creator>
	<dc:creator>Tamin, Tirza Z</dc:creator>
	<dc:creator>Soewondo, Pradana</dc:creator>
	<dc:creator>Rochmah, Wasilah</dc:creator>
	<dc:creator>Nafrialdi, Nafrialdi</dc:creator>
	<dc:creator>Prihartono, Joedo</dc:creator>
	<dc:subject xml:lang="en-US">elderly</dc:subject>
	<dc:subject xml:lang="en-US">gait speed</dc:subject>
	<dc:subject xml:lang="en-US">handgrip strength</dc:subject>
	<dc:subject xml:lang="en-US">health-related quality of life</dc:subject>
	<dc:subject xml:lang="en-US">metformin</dc:subject>
	<dc:subject xml:lang="en-US">myostatin serum</dc:subject>
	<dc:subject xml:lang="en-US">pre-frail</dc:subject>
	<dc:description xml:lang="en-US">Background: sarcopenia contributes to the development of frailty syndrome. Frailty syndrome is potentially improved by modifying insulin resistance, inflammation, and myostatin level. This study is aimed to investigate the effect of metformin on handgrip strength, gait speed, myostatin serum level, and health-related quality of life (HR-QoL) among non-diabetic pre-frail elderly patients. Methods: a double blind randomized controlled trial study was conducted on non-diabetic elderly outpatients aged ≥ 60 years with pre-frail status based on phenotype and/ or index criteria (Cardiovascular Health Study and/ or Frailty Index 40 items) consecutively recruited from March 2015 to June 2016 at Cipto Mangunkusumo Hospital. One-hundred-twenty subjects who met the research criteria were randomized and equally assigned into 3 x 500 mg metformin or placebo group. The study outcomes were measured at baseline and after 16 weeks of intervention. Results: out of 120 subjects, 43 subjects in metformin group and 48 subjects in placebo group who completed the intervention. There was a significant improvement on the mean gait speed of metformin group by 0.39 (0.77) second or 0.13 (0.24) meter/second that remained significant after adjusting for important prognostic factors (p = 0.024). There was no significant difference on handgrip strength, myostatin serum level, and HR-QoL between both groups. Conclusion: 3 x 500 mg metformin for 16 weeks was statistically significant and clinically important in improving usual gait speed as one of the HR-QoL dimensions, but did not significantly improve the EQ-5D index score, handgrip strength, nor myostatin serum level.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2017-08-08</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/330</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 49 No. 2 (2017): Acta Medica Indonesiana; 118</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/330/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2017 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>