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Prediction of Wound Healing in Diabetic Foot Ulcers: an Observational Study in Tertiary Hospital in Indonesia

ACTA MEDICA INDONESIANA · Vol. 49 No. 1 (2017) · hlm. 41–51

ISSN
2338-2732, 0125-9326
Terbit
2017-05-10
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Aim: to evaluate the role of clinical characteristics, functional markers of vasodilation, inflammatory response, and atherosclerosis in predicting wound healing in diabetic foot ulcer. Methods: a cohort study (February – October 2010) was conducted from 40 subjects with acute diabetic foot ulcer at clinical ward of Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia. Each subject underwent at least two variable measurements, i.e. during inflammatory phase and proliferation phase. The studied variables were clinical characteristics, complete peripheral blood count (CBC) and differential count, levels of HbA1c, ureum, creatinine, lipid profile, fasting blood glucose (FBG), marker of endothelial dysfunction (asymmetric dimethylarginine/ADMA, endothelin-1/ET-1, and flow-mediated dilation/FMD of brachial artery), and marker of vascular calcification (osteoprotegerin/OPG). Results: median of time achieving 50% granulation tissue in our study was 21 days. There were nine factors that contribute in the development of 50% granulation tissue, i.e. family history of diabetes mellitus (DM), previous history of wound, wound area, duration of existing wound, captopril and simvastatin medications, levels of ADMA, ET-1, and OPG. There were three out of the nine factors that significantly correlated with wound healing, i.e. wound area, OPG levels, and simvastatin medications. Conclusion: in acute diabetic foot ulcers, wound area and OPG levels had positive correlation with wound healing, whereas simvastatin medications had negative correlation with wound healing.

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  • University of Indonesia
  • Joint United Nations Programme on HIV/AIDS
  • Kementerian Kesehatan Republik Indonesia
  • State University of Semarang
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Rekan penulisOrganisasiArtikel bersama
Dyah PurnamasariAfiliasi tidak diketahui4
Siti SetiatiAfiliasi tidak diketahui3
Joedo PrihartonoAfiliasi tidak diketahui2
Tri Juli Edi TariganUniversity of Indonesia2
Suharko SoebardiAfiliasi tidak diketahui2
Imam SubektiAfiliasi tidak diketahui2
Dante Saksono HarbuwonoAfiliasi tidak diketahui2
Wismandari WisnuAfiliasi tidak diketahui2
Budiman DarmowidjojoAfiliasi tidak diketahui2
Dicky Levenus TahaparyAfiliasi tidak diketahui2
Farid KurniawanAfiliasi tidak diketahui2
Indrati SuroyoAfiliasi tidak diketahui2
Alvita Dewi SiswoyoAfiliasi tidak diketahui2
Soehartati GondhowiardjoAfiliasi tidak diketahui2
Henry KodratAfiliasi tidak diketahui2
Hamzah ShatriAfiliasi tidak diketahui2
Suhendro SuwartoAfiliasi tidak diketahui2
Nafrialdi NafrialdiAfiliasi tidak diketahui2
Tirza Z TaminAfiliasi tidak diketahui2
Kuntjoro HarimurtiAfiliasi tidak diketahui2
Lely WahyuniarJoint United Nations Programme on HIV/AIDS1
Abas B. DjauhariKementerian Kesehatan Republik Indonesia1
Ratna DjuwitaUniversity of Indonesia1
Samsuridjal DjauziAfiliasi tidak diketahui1
Suzanna ImmanuelAfiliasi tidak diketahui1
Neila Mona AG MandeyAfiliasi tidak diketahui1
Soedjatmiko SoedjatmikoState University of Semarang1
Hartono GunardiAfiliasi tidak diketahui1
Liza F ZaimiAfiliasi tidak diketahui1
Turyadi TuryadiAfiliasi tidak diketahui1
David H MuljonoAfiliasi tidak diketahui1
Sarwono WaspadjiAfiliasi tidak diketahui1
Herdiman T PohanAfiliasi tidak diketahui1
Samuel OetoroAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Prediction of Wound Healing in Diabetic Foot Ulcers: an Observational Study in Tertiary Hospital in Indonesia</dc:title>
	<dc:creator>Soewondo, Pradana</dc:creator>
	<dc:creator>Suyono, Slamet</dc:creator>
	<dc:creator>Sastrosuwignyo, Mpu Kanoko</dc:creator>
	<dc:creator>Harahap, Alida R</dc:creator>
	<dc:creator>Sutrisna, Bambang</dc:creator>
	<dc:creator>Makmun, Lukman H</dc:creator>
	<dc:subject xml:lang="en-US">diabetic ulcer</dc:subject>
	<dc:subject xml:lang="en-US">wound healing</dc:subject>
	<dc:subject xml:lang="en-US">endothelial dysfunction</dc:subject>
	<dc:subject xml:lang="en-US">vascular calcification</dc:subject>
	<dc:description xml:lang="en-US">Aim: to evaluate the role of clinical characteristics, functional markers of vasodilation, inflammatory response, and atherosclerosis in predicting wound healing in diabetic foot ulcer. Methods: a cohort study (February – October 2010) was conducted from 40 subjects with acute diabetic foot ulcer at clinical ward of Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia. Each subject underwent at least two variable measurements, i.e. during inflammatory phase and proliferation phase. The studied variables were clinical characteristics, complete peripheral blood count (CBC) and differential count, levels of HbA1c, ureum, creatinine, lipid profile, fasting blood glucose (FBG), marker of endothelial dysfunction (asymmetric dimethylarginine/ADMA, endothelin-1/ET-1, and flow-mediated dilation/FMD of brachial artery), and marker of vascular calcification (osteoprotegerin/OPG). Results: median of time achieving 50% granulation tissue in our study was 21 days. There were nine factors that contribute in the development of 50% granulation tissue, i.e. family history of diabetes mellitus (DM), previous history of wound, wound area, duration of existing wound, captopril and simvastatin medications, levels of ADMA, ET-1, and OPG. There were three out of the nine factors that significantly correlated with wound healing, i.e. wound area, OPG levels, and simvastatin medications. Conclusion: in acute diabetic foot ulcers, wound area and OPG levels had positive correlation with wound healing, whereas simvastatin medications had negative correlation with wound healing.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2017-05-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/348</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 49 No. 1 (2017): Acta Medica Indonesiana; 41-51</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/348/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2017 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>