Sero- and Molecular Epidemiology of HIV-1 in Papua Province, Indonesia

Yunifiar M, Muhammad Qushai; Kotaki, Tomohiro; Witaningrum, Adiana Mutamsari; Khairunisa, Siti Qamariyah; Indriati, Dwi Wahyu; Meilani, Meilani; Yeheskiel, Tigor; Ueda, Shuhei; Nasronudin, Nasronudin; Kameoka, Masanori

Jurnal SINTA 1

Sero- and Molecular Epidemiology of HIV-1 in Papua Province, Indonesia

ACTA MEDICA INDONESIANA · Vol. 49 No. 3 (2017)

ISSN: 2338-2732, 0125-9326
Terbit: 2017-11-02
Penerbit: The Indonesian Society of Internal Medicine
Bahasa: eng

Abstrak

Background: human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) cause serious health problems and affect the Indonesian economy. Papua province has the highest prevalence of HIV infection in the country; however, epidemiological data are limited. Therefore, in order to reveal the current situation of HIV/AIDS in Papua province, sero- and molecular epidemiological studies of HIV were conducted. Methods: serological tests were conducted on 157 healthy individuals from the general population residing in Paniai, Papua. In addition, a molecular epidemiological study was then conducted on HIV type 1 (HIV-1) genes derived from infected individuals. Peripheral blood samples from HIV-1-positive individuals and 15 additionally enrolled, previously confirmed HIV-1-positive individuals were subjected to a genotypic analysis. Results: serological tests revealed that 2 out of 157 (1.27%) healthy individuals were HIV-positive. In addition, HIV-1 subtyping revealed that subtype B and CRF01_AE were the major subtype and circulating recombinant form (CRF) of HIV-1 prevalent in the region, while subtype A1 and a recombinant form including viral gene fragments of CRF01_AE and subtype B was also detected. In addition, HIV drug resistance-associated major mutations were detected in the reverse transcriptase gene derived from infected individual on antiretroviral therapy. Conclusion: these results provide important information for clearer understanding on the current situation of HIV/AIDS in Papua province in Indonesia.

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Rekan penulis	Organisasi	Artikel bersama
Ni Luh Ayu Megasari	Afiliasi tidak diketahui	9
M Qushai Yunifiar	Afiliasi tidak diketahui	7
Brian Eka Rachman	Afiliasi tidak diketahui	6
Devi Oktafiani	Afiliasi tidak diketahui	5
Elsa Fitriana	Afiliasi tidak diketahui	5
Soetjipto Soetjipto	Afiliasi tidak diketahui	5
M Vitanata Arfijanto	Afiliasi tidak diketahui	4
Usman Hadi	Afiliasi tidak diketahui	4
Wiwiek Indriyani Maskoep	Afiliasi tidak diketahui	2
Pauline Ciuputri	Afiliasi tidak diketahui	2
Fhahira Rizkhika Admadiani	Afiliasi tidak diketahui	2
Sarah Fitria Andini	Afiliasi tidak diketahui	2
Tri Pudi Asmarawati	Afiliasi tidak diketahui	2

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.

Metadata asli (oai_dc)

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	<dc:title xml:lang="en-US">Sero- and Molecular Epidemiology of HIV-1 in Papua Province, Indonesia</dc:title>
	<dc:creator>Yunifiar M, Muhammad Qushai</dc:creator>
	<dc:creator>Kotaki, Tomohiro</dc:creator>
	<dc:creator>Witaningrum, Adiana Mutamsari</dc:creator>
	<dc:creator>Khairunisa, Siti Qamariyah</dc:creator>
	<dc:creator>Indriati, Dwi Wahyu</dc:creator>
	<dc:creator>Meilani, Meilani</dc:creator>
	<dc:creator>Yeheskiel, Tigor</dc:creator>
	<dc:creator>Ueda, Shuhei</dc:creator>
	<dc:creator>Nasronudin, Nasronudin</dc:creator>
	<dc:creator>Kameoka, Masanori</dc:creator>
	<dc:subject xml:lang="en-US">HIV-1</dc:subject>
	<dc:subject xml:lang="en-US">subtype B</dc:subject>
	<dc:subject xml:lang="en-US">CRF01_AE</dc:subject>
	<dc:subject xml:lang="en-US">HIV drug resistance</dc:subject>
	<dc:description xml:lang="en-US">Background: human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) cause serious health problems and affect the Indonesian economy. Papua province has the highest prevalence of HIV infection in the country; however, epidemiological data are limited. Therefore, in order to reveal the current situation of HIV/AIDS in Papua province, sero- and molecular epidemiological studies of HIV were conducted. Methods: serological tests were conducted on 157 healthy individuals from the general population residing in Paniai, Papua. In addition, a molecular epidemiological study was then conducted on HIV type 1 (HIV-1) genes derived from infected individuals. Peripheral blood samples from HIV-1-positive individuals and 15 additionally enrolled, previously confirmed HIV-1-positive individuals were subjected to a genotypic analysis. Results: serological tests revealed that 2 out of 157 (1.27%) healthy individuals were HIV-positive. In addition, HIV-1 subtyping revealed that subtype B and CRF01_AE were the major subtype and circulating recombinant form (CRF) of HIV-1 prevalent in the region, while subtype A1 and a recombinant form including viral gene fragments of CRF01_AE and subtype B was also detected. In addition, HIV drug resistance-associated major mutations were detected in the reverse transcriptase gene derived from infected individual on antiretroviral therapy. Conclusion: these results provide important information for clearer understanding on the current situation of HIV/AIDS in Papua province in Indonesia.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2017-11-02</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">sero- and molecular epidemiology</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/358</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 49 No. 3 (2017): Acta Medica Indonesiana; 205</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/358/249</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2017 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>