Prevalence and Profile of Fibrosis in Diabetic Patients with Non-alcoholic Fatty Liver Disease and the Associated Factors

Prasetya, Ignatius Bima; Hasan, Irsan; Wisnu, Wismandari; Rumende, Cleopas Martin

Jurnal SINTA 1

Prevalence and Profile of Fibrosis in Diabetic Patients with Non-alcoholic Fatty Liver Disease and the Associated Factors

ACTA MEDICA INDONESIANA · Vol. 49 No. 2 (2017)

ISSN: 2338-2732, 0125-9326
Terbit: 2017-08-08
Penerbit: The Indonesian Society of Internal Medicine
Bahasa: eng

Abstrak

Background: the risk of Non-Alcoholic Fatty Liver Disease (NAFLD) is increasing in patients with type-2 diabetes. Prevalence and factors related to the increased risk of NAFLD in diabetic patients in Indonesia has never been studied before. Data regarding the profile of fibrosis in the population has also been unknown. This study aimed to identify the difference on the profile of diabetic patients with and without NAFLD as well as the degree of fibrosis. Methods: the study was conducted using a cross-sectional method in type-2 diabetic patients who were treated at the outpatient clinic of endocrinology and metabolic division in Cipto Mangunkusumo Hospital. Sampling was done consecutively. Collected data comprised of age, duration of diabetes, body mass index (BMI), waist circumference, HDL, triglyceride, and HbA1C levels. Abdominal ultrasonography was conducted for all patients to determine the presence of NAFLD. Patients with NAFLD were subsequently underwent transient elastography in order to assess their degree of liver fibrosis. Chi-square or Fisher’s-Exact tests were used for bivariate analysis and logistic regression was used for multivariate analysis. Results: as many as 186 patients were analyzed in the study and 84 patients (45.2%) were demonstrated to have NAFLD. Transient elastography examinations were carried out in 68 patients and 17 patients (25.0%) were found with severe fibrosis. Univariate analysis showed significant differences on BMI (PR=1.878; 95%CI= 1.296-2.721; p<0.001) and waist circumference (PR=2.368; 95%CI= 1.117-5.017; p=0.018) between patients with and without NAFLD. However, the multivariate test showed that BMI was the only factor that had a significance difference between both groups (OR=2.989; 95%CI=1.625-5.499; p<0.001). Conclusion: prevalence of NAFLD among type-2 diabetic patients in Cipto Mangunkusumo Hospital has reached 45.2% and 25.0% among them had severe fibrosis. BMI is the only factor found to be associated with the occurrence of NAFLD.

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Juferdy Kurniawan	Afiliasi tidak diketahui	10
Hamzah Shatri	Afiliasi tidak diketahui	10
Ikhwan Rinaldi	Afiliasi tidak diketahui	8
Rino Alvani Gani	Afiliasi tidak diketahui	5
Siti Setiati	Afiliasi tidak diketahui	5
Murdani Abdullah	Afiliasi tidak diketahui	5
Erni Juwita Nelwan	Afiliasi tidak diketahui	5
Mira Yulianti	National Research and Innovation Agency	4
Chyntia Olivia Maurine Jasirwan	Afiliasi tidak diketahui	4
Sally Aman Nasution	Afiliasi tidak diketahui	4
Em Yunir	University of Indonesia	4
Rudi Putranto	Afiliasi tidak diketahui	4
Robert Sinto	Afiliasi tidak diketahui	4
Dyah Purnamasari	Afiliasi tidak diketahui	4
Imam Subekti	Afiliasi tidak diketahui	4
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Cosmas Rinaldi A Lesmana	Afiliasi tidak diketahui	3
Kemal Fariz Kalista	Afiliasi tidak diketahui	3
Andri Sanityoso Sulaiman	Afiliasi tidak diketahui	3
Herikurniawan Herikurniawan	Afiliasi tidak diketahui	3
Khie Chen Lie	Afiliasi tidak diketahui	3
Gita Aprilicia	Afiliasi tidak diketahui	3
Dante Saksono Harbuwono	Afiliasi tidak diketahui	3
Dicky Levenus Tahapary	Afiliasi tidak diketahui	3
Farid Kurniawan	Afiliasi tidak diketahui	3
Evy Yunihastuti	Afiliasi tidak diketahui	3
Adityo Susilo	Afiliasi tidak diketahui	3
Leonard Nainggolan	Afiliasi tidak diketahui	3
Iris Rengganis	Afiliasi tidak diketahui	3
Rino A Gani	Afiliasi tidak diketahui	2
Tri Juli Edi Tarigan	University of Indonesia	2
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Metadata asli (oai_dc)

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	<dc:title xml:lang="en-US">Prevalence and Profile of Fibrosis in Diabetic  Patients with Non-alcoholic Fatty Liver Disease and the Associated Factors</dc:title>
	<dc:creator>Prasetya, Ignatius Bima</dc:creator>
	<dc:creator>Hasan, Irsan</dc:creator>
	<dc:creator>Wisnu, Wismandari</dc:creator>
	<dc:creator>Rumende, Cleopas Martin</dc:creator>
	<dc:subject xml:lang="en-US">non-alcoholic fatty liver disease (NAFLD)</dc:subject>
	<dc:subject xml:lang="en-US">diabetes melitus</dc:subject>
	<dc:subject xml:lang="en-US">fibrosis</dc:subject>
	<dc:description xml:lang="en-US">Background: the risk of Non-Alcoholic Fatty Liver Disease (NAFLD) is increasing in patients with type-2 diabetes. Prevalence and factors related to the increased risk of NAFLD in diabetic patients in Indonesia has never been studied before. Data regarding the profile of fibrosis in the population has also been unknown. This study aimed to identify the difference on the profile of diabetic patients with and without NAFLD as well as the degree of fibrosis. Methods: the study was conducted using a cross-sectional method in type-2 diabetic patients who were treated at the outpatient clinic of endocrinology and metabolic division in Cipto Mangunkusumo Hospital. Sampling was done consecutively. Collected data comprised of age, duration of diabetes, body mass index (BMI), waist circumference, HDL, triglyceride, and HbA1C levels. Abdominal ultrasonography was conducted for all patients to determine the presence of NAFLD. Patients with NAFLD were subsequently underwent transient elastography in order to assess their degree of liver fibrosis. Chi-square or Fisher’s-Exact tests were used for bivariate analysis and logistic regression was used for multivariate analysis. Results: as many as 186 patients were analyzed in the study and 84 patients (45.2%) were demonstrated to have NAFLD. Transient elastography examinations were carried out in 68 patients and 17 patients (25.0%) were found with severe fibrosis. Univariate analysis showed significant differences on BMI (PR=1.878; 95%CI= 1.296-2.721; p&amp;lt;0.001) and waist circumference (PR=2.368; 95%CI= 1.117-5.017; p=0.018) between patients with and without NAFLD. However, the multivariate test showed that BMI was the only factor that had a significance difference between both groups (OR=2.989; 95%CI=1.625-5.499; p&amp;lt;0.001). Conclusion: prevalence of NAFLD among type-2 diabetic patients in Cipto Mangunkusumo Hospital has reached 45.2% and 25.0% among them had severe fibrosis. BMI is the only factor found to be associated with the occurrence of NAFLD.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2017-08-08</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/365</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 49 No. 2 (2017): Acta Medica Indonesiana; 91</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/365/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2017 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>