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Diagnostic Accuracy of Platelet/Lymphocyte Ratio for Screening Complex Coronary Lesion in Different Age Group of Patients with Acute Coronary Syndrome

ACTA MEDICA INDONESIANA · Vol. 50 No. 3 (2018)

ISSN
2338-2732, 0125-9326
Terbit
2018-10-16
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: with the increasing number of patients with acute coronary syndrome (ACS) with complex coronary lesion and the increasing needs of coronary artery bypass grafting (CABG) procedures, there is an increasing need for a tool to perform early stratification in high-risk patients, which can be used in daily clinical practice, even at first-line health care facilities setting in Indonesia. It is expected that early stratification of high-risk patients can reduce morbidity and mortality rate in patients with ACS. This study aimed to identify diagnostic accuracy of platelet/lymphocyte ratio (PLR) and the optimum cut-off point of PLR as a screening tool for identifying a complex coronary lesion in patients?45 and >45 years old. Methods: this was a retrospective cross-sectional study, conducted at the ICCU of Cipto Mangunkusumo Hospital. Data was obtained from medical records of adult patients with ACS who underwent coronary angiography between January 2012 - July 2015. The inclusion criteria were adult ACS patients (aged?18 years old), diagnosed with ACS and underwent coronary angiography during hospitalization. Diagnostic accuracy was determined by calculating sensitivity, specificity, positive likelihood ratio (LR+), and negative likelihood ratio (LR-). The cut-off point was determined using ROC curve. Results: the proportion of ACS patients with complex coronary lesion in our study was 47.2%. The optimum cut-off point in patients aged?45 years was 111.06 with sensitivity, specificity, LR+ and LR of 91.3%, 91.9%, 11.27 and 0.09, respectively. The optimum cut-off points in patients aged >45 years was 104.78 with sensitivity, specificity, LR+ and LR of 91.7%, 58.6%, 2.21 and 0.14, respectively. Conclusion: the optimum cut-off point for PLR in patients aged? 45 years is 111.06 and for patients with age >45 years is 104.78 with diagnostic accuracy, represented by AUC of 93.9% (p<0.001) and 77.3% (p<0.001), respectively for both age groups.

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Andhika RachmanAfiliasi tidak diketahui4
Kuntjoro HarimurtiAfiliasi tidak diketahui4
Siti SetiatiAfiliasi tidak diketahui4
Sally Aman NasutionAfiliasi tidak diketahui4
Ikhwan RinaldiAfiliasi tidak diketahui3
Suhendro SuhendroAfiliasi tidak diketahui3
Eka GinanjarAfiliasi tidak diketahui3
Dyah PurnamasariAfiliasi tidak diketahui3
Karmel L TambunanAfiliasi tidak diketahui2
Ina S TimanAfiliasi tidak diketahui2
Em YunirUniversity of Indonesia2
Iris RengganisAfiliasi tidak diketahui2
Pringgodigdo NugrohoAfiliasi tidak diketahui2
Evy YunihastutiAfiliasi tidak diketahui2
Simon SalimAfiliasi tidak diketahui2
Nurul Inayah RahmaniAfiliasi tidak diketahui2
Ika P WijayaAfiliasi tidak diketahui2
Lusiani RusdiAfiliasi tidak diketahui2
Hamzah ShatriAfiliasi tidak diketahui2
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Ahmad Fariz M.Z ZeinAfiliasi tidak diketahui1
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Ari F SyamAfiliasi tidak diketahui1
Birry KarimAfiliasi tidak diketahui1
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Djajadiman GatotAfiliasi tidak diketahui1
Arini SetiawatiAfiliasi tidak diketahui1
T. Djumhana AtmakusumaAfiliasi tidak diketahui1
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Al RasyidAfiliasi tidak diketahui1
Jusuf MisbachAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Diagnostic Accuracy of Platelet/Lymphocyte Ratio for Screening Complex Coronary Lesion in Different Age Group of Patients with Acute Coronary Syndrome</dc:title>
	<dc:creator>Anwar, Irma Wahyuni</dc:creator>
	<dc:creator>Wijaya, Ika Prasetya</dc:creator>
	<dc:creator>Sukrisman, Lugyanti</dc:creator>
	<dc:creator>Nasution, Sally A</dc:creator>
	<dc:creator>Rumende, Cleopas M</dc:creator>
	<dc:subject xml:lang="en-US">PLR</dc:subject>
	<dc:subject xml:lang="en-US">complex coronary lesion</dc:subject>
	<dc:subject xml:lang="en-US">Gensini score</dc:subject>
	<dc:subject xml:lang="en-US">acute coronary syndrome</dc:subject>
	<dc:subject xml:lang="en-US">cardiology</dc:subject>
	<dc:description xml:lang="en-US">Background: with the increasing number of patients with acute coronary syndrome (ACS) with complex coronary lesion and the increasing needs of coronary artery bypass grafting (CABG) procedures, there is an increasing need for a tool to perform early stratification in high-risk patients, which can be used in daily clinical practice, even at first-line health care facilities setting in Indonesia. It is expected that early stratification of high-risk patients can reduce morbidity and mortality rate in patients with ACS. This study aimed to identify diagnostic accuracy of platelet/lymphocyte ratio (PLR) and the optimum cut-off point of PLR as a screening tool for identifying a complex coronary lesion in patients ?45 and &amp;gt;45 years old. Methods: this was a retrospective cross-sectional study, conducted at the ICCU of Cipto Mangunkusumo Hospital. Data was obtained from medical records of adult patients with ACS who underwent coronary angiography between January 2012 - July 2015. The inclusion criteria were adult ACS patients (aged ?18 years old), diagnosed with ACS and underwent coronary angiography during hospitalization. Diagnostic accuracy was determined by calculating sensitivity, specificity, positive likelihood ratio (LR+), and negative likelihood ratio (LR-). The cut-off point was determined using ROC curve. Results: the proportion of ACS patients with complex coronary lesion in our study was 47.2%. The optimum cut-off point in patients aged ?45 years was 111.06 with sensitivity, specificity, LR+ and LR of 91.3%, 91.9%, 11.27 and 0.09, respectively. The optimum cut-off points in patients aged &amp;gt;45 years was 104.78 with sensitivity, specificity, LR+ and LR of 91.7%, 58.6%, 2.21 and 0.14, respectively. Conclusion: the optimum cut-off point for PLR in patients aged ? 45 years is 111.06 and for patients with age &amp;gt;45 years is 104.78 with diagnostic accuracy, represented by AUC of 93.9% (p&amp;lt;0.001) and 77.3% (p&amp;lt;0.001), respectively for both age groups.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2018-10-16</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">cross sectional retrospective study</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/401</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 50 No. 3 (2018): Acta Medica Indonesiana; 185</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/401/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>