Melola Discovery

← Melola Discovery

Jurnal SINTA 1

Comparison of Survival Prediction with Single versus Combination Use of Microcirculation End Point Resuscitation in Sepsis and Septic Shock

ACTA MEDICA INDONESIANA · Vol. 50 No. 4 (2019)

ISSN
2338-2732, 0125-9326
Terbit
2019-01-11
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: lactate clearance and central venous oxygen saturation (ScvO2) are two methods for determining tissue oxygenation adequacy. There is a controversy regarding method better associates with and predicts sepsis and septic shock patients’ mortality. This study address the association of achieving one or two targets of microcirculatory resuscitation endpoints and early mortality in sepsis and septic shock. Methods: a cohort study was conducted in adult sepsis and septic shock patients in Intensive Care Unit, Cipto Mangunkusumo Hospital, Indonesia. Patients’ resuscitation endpoints data and outcome were observed during the first 120 hours of hospitalization. Cox’s proportional hazard regression analysis was used to analyse the early mortality risk in subject groups achieving lactate clearance target only, ScvO2 target only, both targets, and not achieving any target in 6 hours after onset of resuscitation adjusted for number of organ dysfunction. Results: subjects consisted of 268 patients. There were significant differences in the mortality risk between subjects who achieved both targets with subjects who achieved ScvO2 target only (adjusted hazard ratio [aHR] 13.47; 95% confidence interval [CI] 5.17-35.08) and subjects who not achieve any target (aHR 16.12; 95%CI 7.43-34.95). There were insignificant difference the early mortality risk between subjects who achieved both targets with subjects achieved lactate clearance target only (aHR 2.29; 95%CI 0.83-6.32). Conclusion: in patients with sepsis and septic shock, achievement of lactate clearance and ScvO2 targets associates with similar early mortality risk compared to achievement of lactate clearance target only. However, it associates with lower early mortality risk compared with ScvO2 target only.

Kata kunci

Jaringan kolaborasi para penulis

40 penulis · 167 tautan kepenulisan bersama · menampilkan 40 yang paling banyak terhubung

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • University of Indonesia
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Khie Chen LieAfiliasi tidak diketahui9
Leonard NainggolanAfiliasi tidak diketahui7
Sharifah ShakinahAfiliasi tidak diketahui7
Erni Juwita NelwanAfiliasi tidak diketahui6
Kuntjoro HarimurtiAfiliasi tidak diketahui4
Adeline PasaribuAfiliasi tidak diketahui4
Ikhwan RinaldiAfiliasi tidak diketahui4
Randy AdiwinataAfiliasi tidak diketahui3
Cleopas Martin RumendeAfiliasi tidak diketahui3
Erni J NelwanAfiliasi tidak diketahui3
Hamzah ShatriAfiliasi tidak diketahui3
Idrus AlwiAfiliasi tidak diketahui2
Rudi PutrantoAfiliasi tidak diketahui2
Suryo Anggoro Kusumo WibowoAfiliasi tidak diketahui2
Noto DwimartutieAfiliasi tidak diketahui2
Irsan HasanAfiliasi tidak diketahui2
Adeline Intan PasaribuAfiliasi tidak diketahui2
Siti SetiatiAfiliasi tidak diketahui2
Arif MansjoerAfiliasi tidak diketahui2
Bambang SutrisnaUniversity of Indonesia1
Sarwono WaspadjiAfiliasi tidak diketahui1
Herdiman T PohanAfiliasi tidak diketahui1
Evi IndrasantiAfiliasi tidak diketahui1
Farida NurchaidaAfiliasi tidak diketahui1
Rustadi SosrosumihardjoAfiliasi tidak diketahui1
Andi KristantoAfiliasi tidak diketahui1
Silvia SumintoAfiliasi tidak diketahui1
Benny N KurniawanAfiliasi tidak diketahui1
Finna ChristiantyAfiliasi tidak diketahui1
Rino A GaniAfiliasi tidak diketahui1
Laurentius A LesmanaAfiliasi tidak diketahui1
Jacub PandelakiAfiliasi tidak diketahui1
Siti B KresnoAfiliasi tidak diketahui1
Tonny LohoAfiliasi tidak diketahui1
Rahajeng N TunjungputriAfiliasi tidak diketahui1
Narottama TunjungAfiliasi tidak diketahui1
Helio GuterresAfiliasi tidak diketahui1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Comparison of Survival Prediction with Single versus Combination Use of Microcirculation End Point Resuscitation in Sepsis and Septic Shock</dc:title>
	<dc:creator>Sinto, Robert</dc:creator>
	<dc:creator>Suwarto, Suhendro</dc:creator>
	<dc:creator>Widodo, Djoko</dc:creator>
	<dc:subject xml:lang="en-US">central venous oxygen saturation</dc:subject>
	<dc:subject xml:lang="en-US">early mortality</dc:subject>
	<dc:subject xml:lang="en-US">lactate clearance</dc:subject>
	<dc:subject xml:lang="en-US">sepsis</dc:subject>
	<dc:subject xml:lang="en-US">septic shock</dc:subject>
	<dc:subject xml:lang="en-US">infection</dc:subject>
	<dc:description xml:lang="en-US">Background: lactate clearance and central venous oxygen saturation (ScvO2) are two methods for determining tissue oxygenation adequacy. There is a controversy regarding method better associates with and predicts sepsis and septic shock patients’ mortality. This study address the association of achieving one or two targets of microcirculatory resuscitation endpoints and early mortality in sepsis and septic shock. Methods: a cohort study was conducted in adult sepsis and septic shock patients in Intensive Care Unit, Cipto Mangunkusumo Hospital, Indonesia. Patients’ resuscitation endpoints data and outcome were observed during the first 120 hours of hospitalization. Cox’s proportional hazard regression analysis was used to analyse the early mortality risk in subject groups achieving lactate clearance target only, ScvO2 target only, both targets, and not achieving any target in 6 hours after onset of resuscitation adjusted for number of organ dysfunction. Results: subjects consisted of 268 patients. There were significant differences in the mortality risk between subjects who achieved both targets with subjects who achieved ScvO2 target only (adjusted hazard ratio [aHR] 13.47; 95% confidence interval [CI] 5.17-35.08) and subjects who not achieve any target (aHR 16.12; 95%CI 7.43-34.95). There were insignificant difference the early mortality risk between subjects who achieved both targets with subjects achieved lactate clearance target only (aHR 2.29; 95%CI 0.83-6.32). Conclusion: in patients with sepsis and septic shock, achievement of lactate clearance and ScvO2 targets associates with similar early mortality risk compared to achievement of lactate clearance target only. However, it associates with lower early mortality risk compared with ScvO2 target only.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2019-01-11</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Cohort retrospective</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/514</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 50 No. 4 (2018): Acta Medica Indonesiana; 275</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/514/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2019 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>