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Indonesia Cohort of IO HAT Study to Evaluate Diabetes Management, Control, and Complications in Retrospective and Prospective Periods Among Insulin-Treated Patients with Type 1 and Type 2 Diabetes

ACTA MEDICA INDONESIANA · Vol. 50 No. 1 (2018)

ISSN
2338-2732, 0125-9326
Terbit
2018-04-20
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: hypoglycemia is a major adverse event of insulin therapy for diabetes mellitus patients. The study was conducted to evaluate the incidence of hypoglycemia among insulin treated patients with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) in the Indonesian cohort. Methods: this Indonesian cohort study consisted of retrospective and prospective evaluation of hypoglycemic episodes, using International Operations Hypoglycemia Assessment Tool (IO HAT) in 374 patients with diabetes (T1DM; n=17 or T2DM; n=357). The patients of ≥18 years of age and treated with insulin for >12 months were selected for this study (ClinicalTrials.gov number: NCT02306681). Results: a total of 374 patients were enrolled in this study and completed SAQ1. All patients with T1DM (17 [100%]), and 347 (97.2%) patients with T2DM completed SAQ2. Almost all the patients in the 4-week prospective period reported at least one hypoglycemic event (T1DM 100%, T2DM 99.4%) and the incidence rate of any hypoglycemia was 67.5 events per patient-year (PPY) and 25.7 events PPY for T1DM and T2DM patients, respectively. Among patients with T1DM and T2DM, 5.9% and 36.4%, respectively, did not know what hypoglycemia was at baseline, also high proportion of patients had impaired hypoglycemic awareness in the study (82.4% and 62.7%, respectively). Conclusion: overall, high proportion of patients reported hypoglycemic events in the prospective period indicating under reporting during the retrospective period due to recall bias. Therefore, there is a need for patient education program to improve the awareness of hypoglycemia in diabetes patient in Indonesia.

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Rekan penulisOrganisasiArtikel bersama
Tri Juli Edi TariganUniversity of Indonesia4
Hamzah ShatriAfiliasi tidak diketahui4
Imam SubektiAfiliasi tidak diketahui3
Cleopas Martin RumendeAfiliasi tidak diketahui3
Siti SetiatiAfiliasi tidak diketahui2
Ika Prasetya WijayaAfiliasi tidak diketahui2
Lisnawati LisnawatiUniversitas Teknologi Sumbawa2
Indrati SuroyoAfiliasi tidak diketahui2
Idrus AlwiAfiliasi tidak diketahui2
Pringgodigdo NugrohoAfiliasi tidak diketahui2
Rudi PutrantoAfiliasi tidak diketahui2
Petrin Redayani LukmanAfiliasi tidak diketahui2
Muhammad Hanif NadhifUniversity of Indonesia1
Hanif AssyarifyAfiliasi tidak diketahui1
Muhammad IrsyadAfiliasi tidak diketahui1
Angela SarumpaetUniversity of Indonesia1
Eni IswatiUniversity of Indonesia1
Indra WijayaAfiliasi tidak diketahui1
Dharmeizar DharmeizarAfiliasi tidak diketahui1
Laurentius A PramonoAfiliasi tidak diketahui1
Dante S HarbuwonoAfiliasi tidak diketahui1
Hari HendartoAfiliasi tidak diketahui1
Wardhana WardhanaAfiliasi tidak diketahui1
Johanda DamanikAfiliasi tidak diketahui1
Dyah PurnamasariAfiliasi tidak diketahui1
Pradana SoewondoAfiliasi tidak diketahui1
Suharko SoebardiAfiliasi tidak diketahui1
Dante Saksono HarbuwonoAfiliasi tidak diketahui1
Wismandari WisnuAfiliasi tidak diketahui1
Budiman DarmowidjojoAfiliasi tidak diketahui1
Dicky Levenus TahaparyAfiliasi tidak diketahui1
Farid KurniawanAfiliasi tidak diketahui1
Erwin Danil YulianAfiliasi tidak diketahui1
Agnes StephanieAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Indonesia Cohort of IO HAT Study to Evaluate Diabetes Management, Control, and Complications in Retrospective and Prospective Periods Among Insulin-Treated Patients with Type 1 and Type 2 Diabetes</dc:title>
	<dc:creator>Rudijanto, Achmad</dc:creator>
	<dc:creator>Saraswati, Made R</dc:creator>
	<dc:creator>Yunir, Em</dc:creator>
	<dc:creator>Kumala, Poppy</dc:creator>
	<dc:creator>Puteri, Happy HS</dc:creator>
	<dc:creator>Mandang, Veny VV</dc:creator>
	<dc:subject xml:lang="en-US">International Operations Hypoglycemia Assessment Tool</dc:subject>
	<dc:subject xml:lang="en-US">Hypoglycemia</dc:subject>
	<dc:subject xml:lang="en-US">insulin-treated patients with diabetes</dc:subject>
	<dc:subject xml:lang="en-US">observational</dc:subject>
	<dc:subject xml:lang="en-US">Indonesia</dc:subject>
	<dc:description xml:lang="en-US">Background: hypoglycemia is a major adverse event of insulin therapy for diabetes mellitus patients. The study was conducted to evaluate the incidence of hypoglycemia among insulin treated patients with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) in the Indonesian cohort. Methods: this Indonesian cohort study consisted of retrospective and prospective evaluation of hypoglycemic episodes, using International Operations Hypoglycemia Assessment Tool (IO HAT) in 374 patients with diabetes (T1DM; n=17 or T2DM; n=357). The patients of ≥18 years of age and treated with insulin for &amp;gt;12 months were selected for this study (ClinicalTrials.gov number: NCT02306681). Results: a total of 374 patients were enrolled in this study and completed SAQ1. All patients with T1DM (17 [100%]), and 347 (97.2%) patients with T2DM completed SAQ2. Almost all the patients in the 4-week prospective period reported at least one hypoglycemic event (T1DM 100%, T2DM 99.4%) and the incidence rate of any hypoglycemia was 67.5 events per patient-year (PPY) and 25.7 events PPY for T1DM and T2DM patients, respectively. Among patients with T1DM and T2DM, 5.9% and 36.4%, respectively, did not know what hypoglycemia was at baseline, also high proportion of patients had impaired hypoglycemic awareness in the study (82.4% and 62.7%, respectively). Conclusion: overall, high proportion of patients reported hypoglycemic events in the prospective period indicating under reporting during the retrospective period due to recall bias. Therefore, there is a need for patient education program to improve the awareness of hypoglycemia in diabetes patient in Indonesia.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2018-04-20</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/550</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 50 No. 1 (2018): Acta Medica Indonesiana; 26</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/550/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>