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The Benefit of Interferon-Gamma Release Assay for Diagnosis of Extrapulmonary Tuberculosis

ACTA MEDICA INDONESIANA · Vol. 50 No. 2 (2018)

ISSN
2338-2732, 0125-9326
Terbit
2018-06-26
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: there are many researches about IGRA in extrapulmonary Tuberculosis (TB), but there only few data from developing countries. This was the first research about the utility of IGRA in extrapulmonary TB performed in Indonesia as developing country with the 2nd most frequent of TB cases in the world. This study aimed to identify the advantage of IGRA examination in diagnosing extrapulmonary TB. Methods: eighty-four patients, presumed to have extrapulmonary TB were examined with IGRA and gold standard examination. The gold standard examination was performed by histopathologic examination, and tissue smear for acid-fast bacilli. Results: among 84 patients included in the study, 57 patients were tested positive with gold standard, where 50 patients among them were also tested positive with IGRA. Among 27 patients tested negative with gold standard, IGRA positive was found in 10 patients. Lymphadenitis was the most common manifestation of the extrapulmonary TB. Diagnostic test from IGRA for extrapulmonary TB found as follows: sensitivity 87,71%, specificity 63%, positive predictive value 83,33%, and negative predictive value 70,83%. Conclusion: IGRA could be used as supporting tool in the diagnosis of extrapulmonary TB. The negative result, however, does not indicate absence of TB infection.

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Hamzah ShatriAfiliasi tidak diketahui7
Ikhwan RinaldiAfiliasi tidak diketahui5
Siti SetiatiAfiliasi tidak diketahui4
Mira YuliantiNational Research and Innovation Agency4
Sally Aman NasutionAfiliasi tidak diketahui3
Herikurniawan HerikurniawanAfiliasi tidak diketahui3
Murdani AbdullahAfiliasi tidak diketahui3
Khie Chen LieAfiliasi tidak diketahui3
Erni Juwita NelwanAfiliasi tidak diketahui3
Em YunirUniversity of Indonesia3
Rudi PutrantoAfiliasi tidak diketahui3
Robert SintoAfiliasi tidak diketahui3
Ignatius Bima PrasetyaAfiliasi tidak diketahui2
Ceva Wicaksono PitoyoAfiliasi tidak diketahui2
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Truely P SitorusAfiliasi tidak diketahui2
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Leonard NainggolanAfiliasi tidak diketahui2
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Hasan MaulahelaAfiliasi tidak diketahui2
Imam SubektiAfiliasi tidak diketahui2
Juferdy KurniawanAfiliasi tidak diketahui2
Irsan HasanAfiliasi tidak diketahui1
Wismandari WisnuAfiliasi tidak diketahui1
Muhadi MuhadiAfiliasi tidak diketahui1
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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The Benefit of Interferon-Gamma Release Assay for Diagnosis of Extrapulmonary Tuberculosis</dc:title>
	<dc:creator>Rumende, Cleopas Martin</dc:creator>
	<dc:creator>Hadi, Edward J</dc:creator>
	<dc:creator>Tanjung, Gloria</dc:creator>
	<dc:creator>Saputri, Imelda N</dc:creator>
	<dc:creator>Sasongko, Raditya</dc:creator>
	<dc:subject xml:lang="en-US">extrapulmonary TB</dc:subject>
	<dc:subject xml:lang="en-US">IGRA</dc:subject>
	<dc:subject xml:lang="en-US">histopathology</dc:subject>
	<dc:subject xml:lang="en-US">tissue acid-fast bacilli</dc:subject>
	<dc:subject xml:lang="en-US">internal medicine</dc:subject>
	<dc:description xml:lang="en-US">Background: there are many researches about IGRA in extrapulmonary Tuberculosis (TB), but there only few data from developing countries. This was the first research about the utility of IGRA in extrapulmonary TB performed in Indonesia as developing country with the 2nd most frequent of TB cases in the world. This study aimed to identify the advantage of IGRA examination in diagnosing extrapulmonary TB. Methods: eighty-four patients, presumed to have extrapulmonary TB were examined with IGRA and gold standard examination. The gold standard examination was performed by histopathologic examination, and tissue smear for acid-fast bacilli. Results: among 84 patients included in the study, 57 patients were tested positive with gold standard, where 50 patients among them were also tested positive with IGRA. Among 27 patients tested negative with gold standard, IGRA positive was found in 10 patients. Lymphadenitis was the most common manifestation of the extrapulmonary TB. Diagnostic test from IGRA for extrapulmonary TB found as follows: sensitivity 87,71%, specificity 63%, positive predictive value 83,33%, and negative predictive value 70,83%. Conclusion: IGRA could be used as supporting tool in the diagnosis of extrapulmonary TB. The negative result, however, does not indicate absence of TB infection.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2018-06-26</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">eighty-four patients, presumed to have extrapulmonary TBwere examined with IGRA and gold standard examination. The gold standard examination was performed by histopathology examination,andtissue smear for acid-fast bacilli</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/731</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 50 No. 2 (2018): Acta Medica Indonesiana; 138</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/731/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>