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Association between A1166C Polymorphism of the Angiotensin II Type-1 Receptor Gene and Type-2 Diabetic Nephropathy in an Indonesian Malay Population

ACTA MEDICA INDONESIANA · Vol. 50 No. 4 (2019)

ISSN
2338-2732, 0125-9326
Terbit
2019-01-11
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: diabetic nephropathy (DN) is the leading cause of blood dialysis worldwide and a major etiology of End-Stage Renal Disease cases in Indonesia. Previous studies showed a relevant link between A1166C polymorphism of Angiotensin II Type-1 Receptor (AT1R) gene and glomerular hyper-filtration as a part of pathogenesis of DN. The aim of this study was to elaborate the association between A1166C AT1R polymorphism and susceptibility of individual with type-2 diabetes to DN in Malay Indonesian population. Methods: a case-control study of 120 consecutive patients with type-2 diabetes mellitus (40 patients in each groups for macro-albuminuria, micro-albuminuria, and normo-albuminuria) was conducted for A1166C AT1R gene polymorphism. The A1166C polymorphism of the AT1R gene was determined based on PCR/RFLP. Results: the mutant C allele was found in 5%, 13.75%, and 12.5% in normo-, micro-, and macro-albuminuria patients respectively. The heterozygote AC genotype was found significantly higher in micro-albuminuria, compared to normo-albuminuria group. Heterozygote AC genotype (OR 3.2 [1.01-10.08], p=0.03) and C allele (OR 2.8[0.95-8.67], p=0.038) were significantly higher in DN, indicating A1166C AT1R gene polymorphism as a risk factor for DN in Malay Indonesian population with type-2 diabetes. Conclusion: there was positive association between A1166C AT1R polymorphism and susceptibility of type-2 diabetics to DN in Malay Indonesian Population. It also indicated that the A1166C AT1R polymorphism could play a role in early pathogenesis of DN.

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Yenny Dian AndayaniAfiliasi tidak diketahui1
Aru Wisaksono SudoyoAfiliasi tidak diketahui1
Mgs. Irsan SalehAfiliasi tidak diketahui1
Legiran LegiranAfiliasi tidak diketahui1
Radiyati Umi PartanAfiliasi tidak diketahui1
Eddy YuristoAfiliasi tidak diketahui1
Fadhyl Zuhry LubisAfiliasi tidak diketahui1
Birry KarimAfiliasi tidak diketahui1
Aida LydiaAfiliasi tidak diketahui1
Pringgodigdo NugrohoAfiliasi tidak diketahui1
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Haerani Abdul RasyidAfiliasi tidak diketahui1
PranawaAfiliasi tidak diketahui1
Nyoman Paramita AyuAfiliasi tidak diketahui1
Siti Elkana NauliAfiliasi tidak diketahui1
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Edrian ZulkarnainAfiliasi tidak diketahui1

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Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Association between A1166C Polymorphism of the Angiotensin II Type-1 Receptor Gene and Type-2 Diabetic Nephropathy in an Indonesian Malay Population</dc:title>
	<dc:creator>Ali, Zulkhair</dc:creator>
	<dc:creator>Kusrini, Ida</dc:creator>
	<dc:creator>Shahab, Alwi</dc:creator>
	<dc:creator>Saleh, Irsan</dc:creator>
	<dc:subject xml:lang="en-US">angiotensin II type-1 receptor</dc:subject>
	<dc:subject xml:lang="en-US">polymorphism</dc:subject>
	<dc:subject xml:lang="en-US">diabetic nephropathy</dc:subject>
	<dc:subject xml:lang="en-US">Nephrology</dc:subject>
	<dc:description xml:lang="en-US">Background: diabetic nephropathy (DN) is the leading cause of blood dialysis worldwide and a major etiology of End-Stage Renal Disease cases in Indonesia. Previous studies showed a relevant link between A1166C polymorphism of Angiotensin II Type-1 Receptor (AT1R) gene and glomerular hyper-filtration as a part of pathogenesis of DN. The aim of this study was to elaborate the association between A1166C AT1R polymorphism and susceptibility of individual with type-2 diabetes to DN in Malay Indonesian population. Methods: a case-control study of 120 consecutive patients with type-2 diabetes mellitus (40 patients in each groups for macro-albuminuria, micro-albuminuria, and normo-albuminuria) was conducted for A1166C AT1R gene polymorphism. The A1166C polymorphism of the AT1R gene was determined based on PCR/RFLP. Results: the mutant C allele was found in 5%, 13.75%, and 12.5% in normo-, micro-, and macro-albuminuria patients respectively. The heterozygote AC genotype was found significantly higher in micro-albuminuria, compared to normo-albuminuria group. Heterozygote AC genotype (OR 3.2 [1.01-10.08], p=0.03) and C allele (OR 2.8[0.95-8.67], p=0.038) were significantly higher in DN, indicating A1166C AT1R gene polymorphism as a risk factor for DN in Malay Indonesian population with type-2 diabetes. Conclusion: there was positive association between A1166C AT1R polymorphism and susceptibility of type-2 diabetics to DN in Malay Indonesian Population. It also indicated that the A1166C AT1R polymorphism could play a role in early pathogenesis of DN.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2019-01-11</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/806</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 50 No. 4 (2018): Acta Medica Indonesiana; 314</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/806/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2019 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>