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The Role of Serum Expression Levels of Microrna-21 on Bone Mineral Density in Hypostrogenic Postmenopausal Women with Osteoporosis: Study on Level of RANKL, OPG, TGFβ-1, Sclerostin, RANKL/OPG Ratio, and Physical Activity

ACTA MEDICA INDONESIANA · Vol. 51 No. 3 (2019)

ISSN
2338-2732, 0125-9326
Terbit
2019-11-07
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: MiR-21 is known to play a role in osteoclast proliferation and differentiation, but the role of serum miR-21 expression in osteoporosis remains unclear. Previous research found that serum miR-21 expression was positively correlated with bone mineral density in postmenopausal osteoporosis patients, but other factors involved in postmenopausal osteoporosis still unknown. This study aimed to determine the role of serum miR-21 expression, concentration of RANKL, OPG, TGF-β1, sclerostin and serum calcium, RANKL/OPG ratio, and physical activity on bone mineral density of spine in hypoestrogenic postmenopausal women with osteoporosis (PMOP) compared with no osteoporosis (PMNOP), with point of interest on the expression of serum miR-21. Methods: this study was conducted by comparative cross-sectional design. The subjects were divided into 2 groups of PMOP and PMNOP. We used an absolute quantification real-time PCR method to determine serum miR-21 expressions level. Results: Median of serum miR-21 expression at the PMOP group was significantly higher compared to PMNOP group (p = 0.001). Serum miR-21 expression, RANKL, RANKL/OPG ratio, and physical activity were significantly correlated with BMD values in the PMOP group. Moderate physical activity was significantly negatively correlated with serum miR-21 expression. We also obtained a linear regression equation BMD = 1.373-0.085*Ln.miR-21-0.176*Log10.RANKL (R2 = 52.5%). Conclusion: serum miR-21 expression in PMOP was higher compared with PMNOP. Serum miR-21 expression proved to have a negative effect on spinal BMD values in hypoestrogenic postmenopausal women with osteoporosis of 8.5%. Obtained equation of BMD = 1.373-0.085*Ln.miR-21-0.176*Log10.RANKL can explain the value of spinal BMD by 52.5%.

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  • Pusat Vulkanologi dan Mitigasi Bencana Geologi
  • University of Indonesia
  • Universitas Teknologi Sumbawa
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Rekan penulisOrganisasiArtikel bersama
Siti SetiatiAfiliasi tidak diketahui5
Dyah PurnamasariAfiliasi tidak diketahui3
Awalia AwaliaAfiliasi tidak diketahui3
Hendra GunawanPusat Vulkanologi dan Mitigasi Bencana Geologi2
Tri Juli Edi TariganUniversity of Indonesia2
Suharko SoebardiAfiliasi tidak diketahui2
Imam SubektiAfiliasi tidak diketahui2
Dante Saksono HarbuwonoAfiliasi tidak diketahui2
Wismandari WisnuAfiliasi tidak diketahui2
Budiman DarmowidjojoAfiliasi tidak diketahui2
Dicky Levenus TahaparyAfiliasi tidak diketahui2
Farid KurniawanAfiliasi tidak diketahui2
Indrati SuroyoAfiliasi tidak diketahui2
Alvita Dewi SiswoyoAfiliasi tidak diketahui2
Soehartati GondhowiardjoAfiliasi tidak diketahui2
Henry KodratAfiliasi tidak diketahui2
Hamzah ShatriAfiliasi tidak diketahui2
Samsuridjal DjauziAfiliasi tidak diketahui2
Rudy HidayatAfiliasi tidak diketahui2
Tirza Z TaminAfiliasi tidak diketahui2
Nafrialdi NafrialdiAfiliasi tidak diketahui2
Purwita Wijaya LaksmiAfiliasi tidak diketahui2
Wasilah RochmahAfiliasi tidak diketahui2
Lisnawati LisnawatiUniversitas Teknologi Sumbawa2
Starry H RampenganAfiliasi tidak diketahui1
Minarma SiagianAfiliasi tidak diketahui1
Suzanna ImmanuelAfiliasi tidak diketahui1
M. KurniawanAfiliasi tidak diketahui1
Salim HarrisAfiliasi tidak diketahui1
Deddy HermawanAfiliasi tidak diketahui1
Bambang SetyohadiAfiliasi tidak diketahui1
Fatimah ElianaAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The Role of Serum Expression Levels of Microrna-21 on Bone Mineral Density in Hypostrogenic Postmenopausal Women with Osteoporosis: Study on Level of RANKL, OPG, TGFβ-1, Sclerostin, RANKL/OPG Ratio, and Physical Activity</dc:title>
	<dc:creator>Suarjana, I Nyoman</dc:creator>
	<dc:creator>Isbagio, Harry</dc:creator>
	<dc:creator>Soewondo, Pradana</dc:creator>
	<dc:creator>Rachman, Ichramsjah A</dc:creator>
	<dc:creator>Sadikin, Mohammad</dc:creator>
	<dc:creator>Prihartono, Joedo</dc:creator>
	<dc:creator>Malik, Safarina G</dc:creator>
	<dc:creator>Soeroso, Joewono</dc:creator>
	<dc:subject xml:lang="en-US">BMD</dc:subject>
	<dc:subject xml:lang="en-US">osteoporosis</dc:subject>
	<dc:subject xml:lang="en-US">serum miR-21</dc:subject>
	<dc:description xml:lang="en-US">Background: MiR-21 is known to play a role in osteoclast proliferation and differentiation, but the role of serum miR-21 expression in osteoporosis remains unclear. Previous research found that serum miR-21 expression was positively correlated with bone mineral density in postmenopausal osteoporosis patients, but other factors involved in postmenopausal osteoporosis still unknown. This study aimed to determine the role of serum miR-21 expression, concentration of RANKL, OPG, TGF-β1, sclerostin and serum calcium, RANKL/OPG ratio, and physical activity on bone mineral density of spine in hypoestrogenic postmenopausal women with osteoporosis (PMOP) compared with no osteoporosis (PMNOP), with point of interest on the expression of serum miR-21. Methods: this study was conducted by comparative cross-sectional design. The subjects were divided into 2 groups of PMOP and PMNOP. We used an absolute quantification real-time PCR method to determine serum miR-21 expressions level. Results: Median of serum miR-21 expression at the PMOP group was significantly higher compared to PMNOP group (p = 0.001). Serum miR-21 expression, RANKL, RANKL/OPG ratio, and physical activity were significantly correlated with BMD values in the PMOP group. Moderate physical activity was significantly negatively correlated with serum miR-21 expression. We also obtained a linear regression equation BMD = 1.373-0.085*Ln.miR-21-0.176*Log10.RANKL (R2 = 52.5%). Conclusion: serum miR-21 expression in PMOP was higher compared with PMNOP. Serum miR-21 expression proved to have a negative effect on spinal BMD values in hypoestrogenic postmenopausal women with osteoporosis of 8.5%. Obtained equation of BMD = 1.373-0.085*Ln.miR-21-0.176*Log10.RANKL can explain the value of spinal BMD by 52.5%.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2019-11-07</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/808</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 51 No. 3 (2019): Acta Medica Indonesiana; 245</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/808/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2019 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>