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The Risk of Developing Non-Alcoholic Fatty Liver Disease in Adult Patients with Subclinical Hypothyroidism Compared to Euthyroid: An Evidence-based Case Report

ACTA MEDICA INDONESIANA · Vol. 51 No. 2 (2019)

ISSN
2338-2732, 0125-9326
Terbit
2019-08-05
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: hypothyroidism is a common concomitant disease of non-alcoholic fatty liver disease (NAFLD). Previous studies regarding the relationship between subclinical hypothyroidism and NAFLD showed conflicting results, ranging from a strong association to not significant one. This case report aimed to investigate the risk of developing NAFLD in subclinical hypothyroidism patients. Methods: literature searching used ScienceDirect, PubMed, ProQuest, and Scopus. Filtering process of titles and abstracts by using inclusion and exclusion criteria yielded 4 eligible articles (1 systematic review, 1 prospective cohort, 1 retrospective cohort, and 1 case-control study) for answering the clinical question. Critical appraisal was conducted by using worksheets from Centre for Evidence-Based Medicine, University of Oxford. Results: the systematic review was considered invalid due to its less comprehensive search for relevant studies, inappropriate article selection to find a causal relationship between diseases, and statistical heterogeneity. The retrospective cohort was decided unimportant because it possessed a relative risk of 0.85 (95% confidence interval [CI], 0.72--1.00) which the upper limit of its CI included 1.00. The rest were valid and had important risk relative and odds ratio (1.27 [95% CI, 1.09--1.47], 3.41 [95% CI, 1.16--9.98]; respectively). The number needed to harm (5—17) indicated the clinically meaningful harm of the exposure since only a few patients with subclinical hypothyroidism is needed to obtain one additional NAFLD incidence. Those two articles were also suitable to be applied in our case. Conclusion: patients with subclinical hypothyroidism, compared to euthyroid patients, are at higher risk of developing NAFLD.

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Tri Juli Edi TariganUniversity of Indonesia3
Dyah PurnamasariAfiliasi tidak diketahui2
Pradana SoewondoAfiliasi tidak diketahui2
Suharko SoebardiAfiliasi tidak diketahui2
Imam SubektiAfiliasi tidak diketahui2
Dante Saksono HarbuwonoAfiliasi tidak diketahui2
Budiman DarmowidjojoAfiliasi tidak diketahui2
Dicky Levenus TahaparyAfiliasi tidak diketahui2
Farid KurniawanAfiliasi tidak diketahui2
Indrati SuroyoAfiliasi tidak diketahui2
Alvita Dewi SiswoyoAfiliasi tidak diketahui2
Soehartati GondhowiardjoAfiliasi tidak diketahui2
Henry KodratAfiliasi tidak diketahui2
Irsan HasanAfiliasi tidak diketahui1
Ignatius Bima PrasetyaAfiliasi tidak diketahui1
Cleopas Martin RumendeAfiliasi tidak diketahui1
Em YunirUniversity of Indonesia1
Lisnawati LisnawatiAfiliasi tidak diketahui1
Erwin Danil YulianAfiliasi tidak diketahui1
Agnes StephanieAfiliasi tidak diketahui1
Benyamin MakesAfiliasi tidak diketahui1
Benny ZulkarnaienAfiliasi tidak diketahui1
Bambang HermaniAfiliasi tidak diketahui1
Marlinda AdhamAfiliasi tidak diketahui1
M SidikAfiliasi tidak diketahui1
Syntia NusantiAfiliasi tidak diketahui1
Salmarezka DewiputriAfiliasi tidak diketahui1
Hernawita SuharkoAfiliasi tidak diketahui1
Gusti G SuardanaAfiliasi tidak diketahui1
Vally WulaniAfiliasi tidak diketahui1
Raksheeth AgarwalAfiliasi tidak diketahui1
Nurcholis NurcholisAfiliasi tidak diketahui1
Hafiz YusaryahyaAfiliasi tidak diketahui1
Nanda Santriayu KarimahAfiliasi tidak diketahui1
Ahmad Yani MansurAfiliasi tidak diketahui1
Gunawan AdhigunaAfiliasi tidak diketahui1
Anshari Saifuddin HasibuanAfiliasi tidak diketahui1
Sukamto KoesnoeAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The Risk of Developing Non-Alcoholic Fatty Liver Disease in Adult Patients with Subclinical Hypothyroidism Compared to Euthyroid: An Evidence-based Case Report</dc:title>
	<dc:creator>Notariza, Kemas Rakhmat</dc:creator>
	<dc:creator>Wisnu, Wismandari</dc:creator>
	<dc:subject xml:lang="en-US">euthyroid</dc:subject>
	<dc:subject xml:lang="en-US">non-alcoholic fatty liver disease</dc:subject>
	<dc:subject xml:lang="en-US">subclinical hypothyroidism</dc:subject>
	<dc:subject xml:lang="en-US">endocrinology</dc:subject>
	<dc:description xml:lang="en-US">Background: hypothyroidism is a common concomitant disease of non-alcoholic fatty liver disease (NAFLD). Previous studies regarding the relationship between subclinical hypothyroidism and NAFLD showed conflicting results, ranging from a strong association to not significant one. This case report aimed to investigate the risk of developing NAFLD in subclinical hypothyroidism patients. Methods: literature searching used ScienceDirect, PubMed, ProQuest, and Scopus. Filtering process of titles and abstracts by using inclusion and exclusion criteria yielded 4 eligible articles (1 systematic review, 1 prospective cohort, 1 retrospective cohort, and 1 case-control study) for answering the clinical question. Critical appraisal was conducted by using worksheets from Centre for Evidence-Based Medicine, University of Oxford. Results: the systematic review was considered invalid due to its less comprehensive search for relevant studies, inappropriate article selection to find a causal relationship between diseases, and statistical heterogeneity. The retrospective cohort was decided unimportant because it possessed a relative risk of 0.85 (95% confidence interval [CI], 0.72--1.00) which the upper limit of its CI included 1.00. The rest were valid and had important risk relative and odds ratio (1.27 [95% CI, 1.09--1.47], 3.41 [95% CI, 1.16--9.98]; respectively). The number needed to harm (5—17) indicated the clinically meaningful harm of the exposure since only a few patients with subclinical hypothyroidism is needed to obtain one additional NAFLD incidence. Those two articles were also suitable to be applied in our case. Conclusion: patients with subclinical hypothyroidism, compared to euthyroid patients, are at higher risk of developing NAFLD.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2019-08-05</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Evidence-based case report</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/907</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 51 No. 2 (2019): Acta Medica Indonesiana; 179</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/907/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2019 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>