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Subclinical Atherosclerosis in Young Adult Population with First Degree Relatives of Type 2 Diabetes Mellitus

ACTA MEDICA INDONESIANA · Vol. 51 No. 2 (2019)

ISSN
2338-2732, 0125-9326
Terbit
2019-08-05
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Cardiovascular disease (CVD) remain a leading cause of death globally. The concept of acute myocardial infarction in young adults was uncommon. Atherosclerosis is the leading cause of CVD, including myocardial infarction, stroke, heart failure and peripheral artery disease. This condition is initiated early in childhood and progressive in nature. CVD risk factors includes hypertension, dyslipidemia and obesity play a role in the development of atherosclerosis and components in insulin resistance syndrome.One of many risk factors for insulin resistance in healthy individuals is a first-degree relative (FDR) of Type 2 Diabetes Mellitus (T2DM) patients. This group shows a higher risk of insulin resistance and pancreatic beta cells disruption even in adolescence, although they often remains asymptomatic. Clinical manifestations of metabolic disorders and atherosclerosis will appear earlier in the FDR T2DM group who have sedentary lifestyles and obesity, when compared to the non-FDR group. Several studies have attempted to detect metabolic disorders and subclinical atherosclerosis that might occur; therefore an early prevention can be carried out in these high-risk groups. Unfortunately, factors that affect the onset and the severity of the prospective clinical manifestations from the previous studies remained inconclusive.

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Hamzah ShatriAfiliasi tidak diketahui7
Siti SetiatiAfiliasi tidak diketahui6
Alvina WidhaniAfiliasi tidak diketahui5
Em YunirUniversity of Indonesia5
Imam SubektiAfiliasi tidak diketahui4
Sally Aman NasutionAfiliasi tidak diketahui4
Kuntjoro HarimurtiAfiliasi tidak diketahui4
Pradana SoewondoAfiliasi tidak diketahui3
Eka GinanjarAfiliasi tidak diketahui3
Dicky Levenus TahaparyAfiliasi tidak diketahui3
Chyntia Olivia Maurine JasirwanAfiliasi tidak diketahui3
Adityo SusiloAfiliasi tidak diketahui3
Rudi PutrantoAfiliasi tidak diketahui3
Sukamto KoesnoeAfiliasi tidak diketahui3
Juferdy KurniawanAfiliasi tidak diketahui3
Murdani AbdullahAfiliasi tidak diketahui2
Tri Juli Edi TariganUniversity of Indonesia2
Suharko SoebardiAfiliasi tidak diketahui2
Dante Saksono HarbuwonoAfiliasi tidak diketahui2
Wismandari WisnuAfiliasi tidak diketahui2
Budiman DarmowidjojoAfiliasi tidak diketahui2
Farid KurniawanAfiliasi tidak diketahui2
Indrati SuroyoAfiliasi tidak diketahui2
Alvita Dewi SiswoyoAfiliasi tidak diketahui2
Soehartati GondhowiardjoAfiliasi tidak diketahui2
Henry KodratAfiliasi tidak diketahui2
Aida LydiaAfiliasi tidak diketahui2
Suhardjono SuhardjonoAfiliasi tidak diketahui2
Sally A NasutionAfiliasi tidak diketahui2
Arif MansjoerAfiliasi tidak diketahui2
Esthika DewiastyAfiliasi tidak diketahui2
Cleopas M RumendeAfiliasi tidak diketahui2
Marcellus SimadibrataAfiliasi tidak diketahui2
Andhika RachmanAfiliasi tidak diketahui2
Muhadi MuhadiAfiliasi tidak diketahui2

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc)
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	<dc:title xml:lang="en-US">Subclinical Atherosclerosis in Young Adult Population with First Degree Relatives of Type 2 Diabetes Mellitus</dc:title>
	<dc:creator>Abdaly, Muhammad Syah</dc:creator>
	<dc:creator>Azizi, Mohamad Syahrir</dc:creator>
	<dc:creator>Wijaya, Ika Prasetya</dc:creator>
	<dc:creator>Nugroho, Pringgodigdo</dc:creator>
	<dc:creator>Purnamasari, Dyah</dc:creator>
	<dc:subject xml:lang="en-US">cardiovascular disease</dc:subject>
	<dc:subject xml:lang="en-US">atherosclerosis</dc:subject>
	<dc:subject xml:lang="en-US">first-degree relative</dc:subject>
	<dc:subject xml:lang="en-US">type 2 diabetes mellitus</dc:subject>
	<dc:description xml:lang="en-US">Cardiovascular disease (CVD) remain a leading cause of death globally. The concept of acute myocardial infarction in young adults was uncommon. Atherosclerosis is the leading cause of CVD, including myocardial infarction, stroke, heart failure and peripheral artery disease. This condition is initiated early in childhood and progressive in nature. CVD risk factors includes hypertension, dyslipidemia and obesity play a role in the development of atherosclerosis and  components in insulin resistance syndrome.One of many risk factors for insulin resistance in healthy individuals is a first-degree relative (FDR) of Type 2 Diabetes Mellitus (T2DM) patients. This group shows a higher risk of insulin resistance and pancreatic beta cells disruption even in adolescence, although they often remains asymptomatic. Clinical manifestations of metabolic disorders and atherosclerosis will appear earlier in the FDR T2DM group who have sedentary lifestyles and obesity, when compared to the non-FDR group. Several studies have attempted to detect metabolic disorders and subclinical atherosclerosis that might occur; therefore an early prevention can be carried out in these high-risk groups.  Unfortunately, factors that affect the onset and the severity of the prospective clinical manifestations from the previous studies remained inconclusive.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2019-08-05</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/971</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 51 No. 2 (2019): Acta Medica Indonesiana; 169</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/971/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2019 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>