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The Association of b2-Microglobulin and Fibroblast Growth Factor 23 with Major Adverse Cardiac Event in Acute Coronary Syndrome Patients with Chronic Kidney Disease

ACTA MEDICA INDONESIANA · Vol. 53 No. 1 (2021)

ISSN
2338-2732, 0125-9326
Terbit
2021-03-31
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: chronic kidney disease (CKD) increases the severity and risk of mortality in acute coronary syndrome (ACS) patients. The role of β2-M as a filtration and inflammation marker and FGF23 as a CKD-MBD process marker might be significant in the pathophysiology in ACS with CKD patients. This study aims to determine the association of β2-M and FGF23 with major adverse cardiac event (MACE) in ACS patients with CKD. Methods: we used cross sectional and retrospective cohort analysis for MACE. We collected ACS patients with CKD consecutively from January until October 2018 at Dr. Cipto Mangunkusumo General Hospital. Data were analyzed using logistic regression and Cox’s Proportional Hazard Regression. Results: a total of 117 patients were selected according to the study criteria. In bivariate analysis, β2-M, FGF23, and stage of CKD had significant association with MACE (p = 0.014, p = 0.026, p = 0.014, respectively). In multivariate analysis, β2-M - but not FGF 23- was significantly associated with MACE (adjusted HR 2.16; CI95% 1.15–4.05; p = 0.017). Conclusion: β2-M was significantly associated with MACE, while FGF23 was not so. This finding supports the role of inflammation in cardiovascular outcomes in ACS with CKD patient through acute on chronic effect.

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  • University of Indonesia
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Siti SetiatiAfiliasi tidak diketahui21
Simon SalimAfiliasi tidak diketahui11
Rudi PutrantoAfiliasi tidak diketahui10
Hamzah ShatriAfiliasi tidak diketahui10
Arif MansjoerAfiliasi tidak diketahui10
Sally Aman NasutionAfiliasi tidak diketahui8
Suhendro SuwartoAfiliasi tidak diketahui7
Noto DwimartutieAfiliasi tidak diketahui6
Evy YunihastutiAfiliasi tidak diketahui6
Andhika RachmanAfiliasi tidak diketahui6
Imam SubektiAfiliasi tidak diketahui6
Birry KarimAfiliasi tidak diketahui5
Em YunirUniversity of Indonesia5
Pringgodigdo NugrohoAfiliasi tidak diketahui5
Annisa Puspitasari NachrowiAfiliasi tidak diketahui5
Roza MulyanaAfiliasi tidak diketahui4
Eka Dian SafitriAfiliasi tidak diketahui4
Rahmi IstantiAfiliasi tidak diketahui4
Ika P WijayaAfiliasi tidak diketahui4
Cosphiadi IrawanAfiliasi tidak diketahui4
Iris RengganisAfiliasi tidak diketahui4
Lies Dina LiastutiAfiliasi tidak diketahui4
Yulianto YuliantoAfiliasi tidak diketahui3
Respati W RanakusumaAfiliasi tidak diketahui3
Siti Rizny F SaldiAfiliasi tidak diketahui3
Jessica MarsigitAfiliasi tidak diketahui3
Sri SunartiAfiliasi tidak diketahui3
Fatichati BudiningsihAfiliasi tidak diketahui3
Lazuardhi DwipaAfiliasi tidak diketahui3
Cleopas Martin RumendeAfiliasi tidak diketahui3
Ceva Wicaksono PitoyoAfiliasi tidak diketahui3
Aulia RizkaAfiliasi tidak diketahui3
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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The Association of b2-Microglobulin and Fibroblast Growth Factor 23 with Major Adverse Cardiac Event in Acute Coronary Syndrome Patients with Chronic Kidney Disease</dc:title>
	<dc:creator>Ginanjar, Eka</dc:creator>
	<dc:creator>Alwi, Idrus</dc:creator>
	<dc:creator>Lydia, Aida</dc:creator>
	<dc:creator>Immanuel, Suzanna</dc:creator>
	<dc:creator>Yamin, Muhammad</dc:creator>
	<dc:creator>Indrajaya, Taufik</dc:creator>
	<dc:creator>Harimurti, Kuntjoro</dc:creator>
	<dc:subject xml:lang="en-US">Beta2-Microglobulin</dc:subject>
	<dc:subject xml:lang="en-US">Fibrioblast Growth Factor 23</dc:subject>
	<dc:subject xml:lang="en-US">Acute Coronary Syndrome</dc:subject>
	<dc:subject xml:lang="en-US">Major Adverse Cardiac Event</dc:subject>
	<dc:subject xml:lang="en-US">Internal Medicine</dc:subject>
	<dc:subject xml:lang="en-US">Cardiology</dc:subject>
	<dc:description xml:lang="en-US">Background: chronic kidney disease (CKD) increases the severity and risk of mortality in acute coronary syndrome (ACS) patients. The role of β2-M as a filtration and inflammation marker and FGF23 as a CKD-MBD process marker might be significant in the pathophysiology in ACS with CKD patients. This study aims to determine the association of β2-M and FGF23 with major adverse cardiac event (MACE) in ACS patients with CKD. Methods: we used cross sectional and retrospective cohort analysis for MACE. We collected ACS patients with CKD consecutively from January until October 2018 at Dr. Cipto Mangunkusumo General Hospital. Data were analyzed using logistic regression and Cox’s Proportional Hazard Regression. Results: a total of 117 patients were selected according to the study criteria. In bivariate analysis, β2-M, FGF23, and stage of CKD had significant association with MACE (p = 0.014, p = 0.026, p = 0.014, respectively). In multivariate analysis, β2-M - but not FGF 23- was significantly associated with MACE (adjusted HR 2.16; CI95% 1.15–4.05; p = 0.017). Conclusion: β2-M was significantly associated with MACE, while FGF23 was not so. This finding supports the role of inflammation in cardiovascular outcomes in ACS with CKD patient through acute on chronic effect.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2021-03-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Cross sectional and Prospective Cohort</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/999</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 53 No. 1 (2021): Acta Medica Indonesiana; 5</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/999/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2021 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>