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The Difference in the Cyclin D1 Expression in Advanced Stage Nasopharyngeal Cancer based on Treatment Response: A Retrospective Cohort Study

ACTA MEDICA INDONESIANA · Vol. 52 No. 2 (2020)

ISSN
2338-2732, 0125-9326
Terbit
2020-08-07
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: nasopharyngeal cancer (NPC) is the most common type of head and neck cancer in Indonesia (28.4%). Reports showed that 18.9% of cases came with advanced stage. Chemotherapy play important role in advanced stage. However, patients with the same stage of the disease may have different treatment response, likely due to the different tumor biological characteristics. Cyclin D1 is a protein involved in the cell cycle, which will stimulate proliferation. This study aimed to examine the proportion of cyclin D1 in NPC and its association with treatment response. Methods: a retrospective cohort study was conducted on advanced NPC patients that underwent chemotherapy at Cipto Mangunkusumo Hospital from 2015 until 2018. Cyclin D1 immunohistochemistry staining was done by antigen retrieval methods using the cyclin D1 NovocastraTM monoclonal antibody. The cyclin D1 expression was evaluated with h-score. Treatment response was reviewed based on the RECIST 1.1 criteria. Results: fifteen subjects (48.4%) had a positive expression of cyclin D1. Higher proportion of cyclin D1 positive was found in responsive group compare with non-responsive group (66.7% vs. 33.3%, p = 0.032). Statistically significant difference in mean h-score was observed between the subjects who responded and those who did not respond (116.24 SD57.80 vs. 77.97 SD45.27, p = 0.048). Conclusion: this study suggests that a higher expression of cyclin D1 is associated with a good treatment response in NPC patients.

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Hamzah ShatriAfiliasi tidak diketahui10
Muchtaruddin MansyurAfiliasi tidak diketahui6
Marlinda AdhamAfiliasi tidak diketahui6
Rudi PutrantoAfiliasi tidak diketahui5
Achmad Fauzi KamalAfiliasi tidak diketahui5
Mardiah Suci HardiantiAfiliasi tidak diketahui5
Marcellus SimadibrataAfiliasi tidak diketahui4
Dadang MakmunAfiliasi tidak diketahui4
Ari Fahrial SyamAfiliasi tidak diketahui4
Ikhwan RinaldiAfiliasi tidak diketahui4
Cleopas Martin RumendeAfiliasi tidak diketahui4
Idrus AlwiAfiliasi tidak diketahui3
Siti SetiatiAfiliasi tidak diketahui3
Dyah PurnamasariAfiliasi tidak diketahui3
Hasan MaulahelaAfiliasi tidak diketahui3
Em YunirUniversity of Indonesia3
Imam SubektiAfiliasi tidak diketahui3
Aulia RizkaAfiliasi tidak diketahui3
Andhika RachmanAfiliasi tidak diketahui3
Sabarudin AhmadAfiliasi tidak diketahui2
Aru W SudoyoAfiliasi tidak diketahui2
Djumhana AtmakusumahAfiliasi tidak diketahui2
Abdulmuthalib AbdulmuthalibAfiliasi tidak diketahui2
Achmad FauziAfiliasi tidak diketahui2
Kaka RenaldiAfiliasi tidak diketahui2
Tri Juli Edi TariganUniversity of Indonesia2
Mizanul AdliAfiliasi tidak diketahui2
Dina ElitaAfiliasi tidak diketahui2
Ratih Arianita AgungAfiliasi tidak diketahui2
Saskia Aziza NursyirwanAfiliasi tidak diketahui2
Pradana SoewondoAfiliasi tidak diketahui2
Czeresna Heriawan SoejonoAfiliasi tidak diketahui2
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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The Difference in the Cyclin D1 Expression in Advanced Stage Nasopharyngeal Cancer based on Treatment Response: A Retrospective Cohort Study</dc:title>
	<dc:creator>Irawan, Cosphiadi</dc:creator>
	<dc:creator>Cahyanur, Rahmat</dc:creator>
	<dc:creator>Lisnawati, Lisnawati</dc:creator>
	<dc:creator>Abdullah, Murdani</dc:creator>
	<dc:creator>Yunus, Reyhan Eddy</dc:creator>
	<dc:subject xml:lang="en-US">cyclin D1</dc:subject>
	<dc:subject xml:lang="en-US">nasopharyngeal cancer</dc:subject>
	<dc:subject xml:lang="en-US">treatment response</dc:subject>
	<dc:description xml:lang="en-US">Background: nasopharyngeal cancer (NPC) is the most common type of head and neck cancer in Indonesia (28.4%). Reports showed that 18.9% of cases came with advanced stage. Chemotherapy play important role in advanced stage. However, patients with the same stage of the disease may have different treatment response, likely due to the different tumor biological characteristics. Cyclin D1 is a protein involved in the cell cycle, which will stimulate proliferation. This study aimed to examine the proportion of cyclin D1 in NPC and its association with treatment response. Methods: a retrospective cohort study was conducted on advanced NPC patients that underwent chemotherapy at Cipto Mangunkusumo Hospital from 2015 until 2018. Cyclin D1 immunohistochemistry staining was done by antigen retrieval methods using the cyclin D1 NovocastraTM monoclonal antibody. The cyclin D1 expression was evaluated with h-score. Treatment response was reviewed based on the RECIST 1.1 criteria. Results: fifteen subjects (48.4%) had a positive expression of cyclin D1. Higher proportion of cyclin D1 positive was found in responsive group compare with non-responsive group (66.7% vs. 33.3%, p = 0.032). Statistically significant difference in mean h-score was observed between the subjects who responded and those who did not respond (116.24 SD57.80 vs. 77.97 SD45.27, p = 0.048). Conclusion: this study suggests that a higher expression of cyclin D1 is associated with a good treatment response in NPC patients.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2020-08-07</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">retrospective cohort</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/1231</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 52 No. 2 (2020): Acta Medica Indonesiana; 147</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/1231/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>