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The Association between Peripheral Th17, Th1, IL-17, and IFN-γ Levels and TACE Response in Patients with Unresectable Hepatocellular Carcinoma with or without Cirrhosis

ACTA MEDICA INDONESIANA · Vol. 52 No. 4 (2020)

ISSN
2338-2732, 0125-9326
Terbit
2020-12-28
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: Th17 cells, a subset of CD4+ T cells with the capacity to produce IL-17, were reported to have pro-tumor and anti-tumor effects. Th1 cells are known for their capacity to eliminate tumor cells by producing IFN-γ. Transarterial chemoembolization (TACE) is a treatment of choice for patients with unresectable hepatocellular carcinoma (HCC). Therefore, this study aimed to determine the association between peripheral Th17, Th1, IL-17, and IFN-γ levels and TACE response in patients with unresectable HCC with or without cirrhosis. Methods: a prospective cohort study was conducted in Cipto Mangunkusumo Hospital and several affiliated hospitals from June 2015 to January 2019. HCC patients with or without cirrhosis who met the inclusion criteria were included in this study. Blood samples were obtained immediately before TACE and 30 days after TACE. Th1 and Th17 cells were analyzed by flowcytometry, while IL-17 and IFN-γ were examined with ELISA method. TACE response was assessed with mRECIST. Results: forty-one HCC patients were enrolled in this study. According to mRECIST, 12 patients were assessed as response group (complete and partial response) and 29 patients were assessed as nonresponse group (stable and progressive disease). Levels of Th1 and Th17 increased significantly after TACE in the response group. On the other hand, IL-17 and IFN-γ decreased after TACE in both groups, although not statistically significant. Interestingly, in the response group, a significant increase was found in the number of T cells subset showing both IFN-γ and IL-17 markers on their surfaces, i.e. CD4+/IFN-γ+/IL-17+ T cells. Conclusion: increased circulating Th1, Th17, and CD4+/IFN-γ+/IL-17+ T cells were observed in HCC patients with complete or partial response to TACE.

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  • University of Indonesia
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Rekan penulisOrganisasiArtikel bersama
Juferdy KurniawanAfiliasi tidak diketahui9
Rino Alvani GaniAfiliasi tidak diketahui5
Andri SanityosoAfiliasi tidak diketahui4
Kuntjoro HarimurtiAfiliasi tidak diketahui4
Hamzah ShatriAfiliasi tidak diketahui4
Cosmas Rinaldi A LesmanaAfiliasi tidak diketahui3
Chyntia Olivia Maurine JasirwanAfiliasi tidak diketahui3
Kemal Fariz KalistaAfiliasi tidak diketahui3
Andri Sanityoso SulaimanAfiliasi tidak diketahui3
Ikhwan RinaldiAfiliasi tidak diketahui3
Gita ApriliciaAfiliasi tidak diketahui3
Rudi PutrantoAfiliasi tidak diketahui3
Idrus AlwiAfiliasi tidak diketahui2
Maulana SuryaminAfiliasi tidak diketahui2
C. Rinaldi A LesmanaAfiliasi tidak diketahui2
Nafrialdi NafrialdiAfiliasi tidak diketahui2
Robert SintoAfiliasi tidak diketahui2
Maruhum Bonar H MarbunAfiliasi tidak diketahui2
Siti SetiatiAfiliasi tidak diketahui2
Bambang SutrisnaUniversity of Indonesia1
Sarwono WaspadjiAfiliasi tidak diketahui1
Herdiman T PohanAfiliasi tidak diketahui1
Ali SulaimanAfiliasi tidak diketahui1
Helyanna HelyannaAfiliasi tidak diketahui1
Indra WijayaAfiliasi tidak diketahui1
Felix F WidjajaAfiliasi tidak diketahui1
Paramita KhairanAfiliasi tidak diketahui1
Telly KameliaAfiliasi tidak diketahui1
Marcellus SimadibrataAfiliasi tidak diketahui1
Ignatius R TenggaraAfiliasi tidak diketahui1
C Rinaldi LesmanaAfiliasi tidak diketahui1
Lutfie LutfieAfiliasi tidak diketahui1
Ignatius Bima PrasetyaAfiliasi tidak diketahui1
Wismandari WisnuAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The Association between Peripheral Th17, Th1, IL-17, and IFN-γ Levels and TACE Response in Patients with Unresectable Hepatocellular Carcinoma with or without Cirrhosis</dc:title>
	<dc:creator>Hasan, Irsan</dc:creator>
	<dc:creator>Gani, Rino A</dc:creator>
	<dc:creator>Lesmana, Laurentius A</dc:creator>
	<dc:creator>Kresno, Siti B</dc:creator>
	<dc:creator>Pandelaki, Jacub</dc:creator>
	<dc:creator>Suwarto, Suhendro</dc:creator>
	<dc:subject xml:lang="en-US">hepatocellular carcinoma</dc:subject>
	<dc:subject xml:lang="en-US">Th1</dc:subject>
	<dc:subject xml:lang="en-US">Th17</dc:subject>
	<dc:subject xml:lang="en-US">transarterial chemoembolization</dc:subject>
	<dc:subject xml:lang="en-US">Hepatology</dc:subject>
	<dc:description xml:lang="en-US">Background: Th17 cells, a subset of CD4+ T cells with the capacity to produce IL-17, were reported to have pro-tumor and anti-tumor effects. Th1 cells are known for their capacity to eliminate tumor cells by producing IFN-γ. Transarterial chemoembolization (TACE) is a treatment of choice for patients with unresectable hepatocellular carcinoma (HCC). Therefore, this study aimed to determine the association between peripheral Th17, Th1, IL-17, and IFN-γ levels and TACE response in patients with unresectable HCC with or without cirrhosis. Methods: a prospective cohort study was conducted in Cipto Mangunkusumo Hospital and several affiliated hospitals from June 2015 to January 2019. HCC patients with or without cirrhosis who met the inclusion criteria were included in this study. Blood samples were obtained immediately before TACE and 30 days after TACE. Th1 and Th17 cells were analyzed by flowcytometry, while IL-17 and IFN-γ were examined with ELISA method. TACE response was assessed with mRECIST. Results: forty-one HCC patients were enrolled in this study. According to mRECIST, 12 patients were assessed as response group (complete and partial response) and 29 patients were assessed as nonresponse group (stable and progressive disease). Levels of Th1 and Th17 increased significantly after TACE in the response group. On the other hand, IL-17 and IFN-γ decreased after TACE in both groups, although not statistically significant. Interestingly, in the response group, a significant increase was found in the number of T cells subset showing both IFN-γ and IL-17 markers on their surfaces, i.e. CD4+/IFN-γ+/IL-17+ T cells. Conclusion: increased circulating Th1, Th17, and CD4+/IFN-γ+/IL-17+ T cells were observed in HCC patients with complete or partial response to TACE.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2020-12-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Prospective cohort study</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/1240</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 52 No. 4 (2020): Acta Medica Indonesiana; 326</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/1240/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>