Melola Discovery

← Melola Discovery

Jurnal SINTA 1

The Role of Acute Hyperglycemia on the Risk of Malignant Arrhythmia in Acute Myocardial Infarction Patients: A Study of Myocardial Damage, Ion Channel Changes and Inflammatory Factors

ACTA MEDICA INDONESIANA · Vol. 52 No. 2 (2020)

ISSN
2338-2732, 0125-9326
Terbit
2020-08-07
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: acute myocardial infarction (AMI) is often followed by hyperglycemia. To date, there is no study that examine the role of myocardial damage, ion channel changes and increased inflammatory response as a pathomechanism of malignant arrhythmias due to hyperglycemia in AMI patients. The aim of this study is to determine the effect of acute hyperglycemia on the occurence of malignant arrhythmias, troponin I, VLP, echocardiographic strain, ion channel changes (CaMKII) and hsCRP. This study also aims to assess the effect of troponin I, VLP, GLS, CaMKII and hsCRP on the occurence of malignant arrhythmias in AMI patients with acute hyperglycemia. Methods: a cross-sectional study followed by a cohort study was conducted on AMI patients treated at ICCU Cipto Mangunkusumo Hospital Jakarta during November 2018 to May 2019 period. Patients with severe infections and who had experienced malignant arrhythmias at admission were excluded from the study. The occurence of malignant arrhythmias as the main outcome of this study and CaMKII level were assessed on the fifth day of treatment. Patients who died before the fifth day of treatment due to causes other than malignant arrhythmias were excluded from analysis. The association between acute hyperglycemia with VLP and the occurence of malignant arrhythmias was analyzed through a chi-square test, whereas the differences between troponin I, GLS, CaMKII and hsCRP, based on the hyperglycemia status of the patient, were analyzed by Mann-Whitney U test. Results: a total of 110 patients were included in the study. Two patients died on the third day of observation due to malignant arrhythmias. No significant relationship was found between acute hyperglycemia in AMI and malignant arrhythmias (RR = 1,38, 95%CI 0.50−3.77). There were differences of CaMKII level on day-1 and day-5 between those who were experienced malignant arrhytmia and those who were not (p-value for differences are 0,03 and 0,01, respectively. In the acute hyperglycemia group, there was difference of CaMKII day-5 levels between positive and negative VLP (p = 0.03). Conclusion: it was concluded that the inititial stage of AMI causes more dominant myocardial damage, as compared to metabolic factors. In the next stage of AMI, acute hyperglycemia increases ROS and the activation of ion channel changes described by CaMKII. This change results in electrophysiological remodeling of the heart, as seen in the VLP image on SA-ECG.

Kata kunci

Jaringan kolaborasi para penulis

40 penulis · 288 tautan kepenulisan bersama · menampilkan 40 yang paling banyak terhubung

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • University of Indonesia
  • Institut Agama Islam Negeri Bone
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Siti SetiatiAfiliasi tidak diketahui19
Hamzah ShatriAfiliasi tidak diketahui13
Eka GinanjarAfiliasi tidak diketahui10
Rudi PutrantoAfiliasi tidak diketahui9
Evy YunihastutiAfiliasi tidak diketahui7
Aida LydiaAfiliasi tidak diketahui7
Taufik IndrajayaAfiliasi tidak diketahui7
Cleopas Martin RumendeAfiliasi tidak diketahui7
Muhammad YaminInstitut Agama Islam Negeri Bone6
Em YunirUniversity of Indonesia6
Arif MansjoerAfiliasi tidak diketahui6
Juferdy KurniawanAfiliasi tidak diketahui6
Adityo SusiloAfiliasi tidak diketahui6
Noto DwimartutieAfiliasi tidak diketahui5
Eka Dian SafitriAfiliasi tidak diketahui5
Dyah PurnamasariAfiliasi tidak diketahui5
Andhika RachmanAfiliasi tidak diketahui5
Ika P WijayaAfiliasi tidak diketahui5
Cosphiadi IrawanAfiliasi tidak diketahui5
Roza MulyanaAfiliasi tidak diketahui4
Rahmi IstantiAfiliasi tidak diketahui4
Dante Saksono HarbuwonoAfiliasi tidak diketahui4
Muhadi MuhadiAfiliasi tidak diketahui4
Birry KarimAfiliasi tidak diketahui4
Cleopas M RumendeAfiliasi tidak diketahui4
Simon SalimAfiliasi tidak diketahui4
Iris RengganisAfiliasi tidak diketahui4
Dicky Levenus TahaparyAfiliasi tidak diketahui4
Ika Prasetya WijayaAfiliasi tidak diketahui3
Lugyanti SukrismanAfiliasi tidak diketahui3

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The Role of Acute Hyperglycemia on the Risk of Malignant Arrhythmia in Acute Myocardial Infarction Patients:  A Study of Myocardial Damage, Ion Channel Changes and Inflammatory Factors</dc:title>
	<dc:creator>Nasution, Sally Aman</dc:creator>
	<dc:creator>Alwi, Idrus</dc:creator>
	<dc:creator>Subekti, Imam</dc:creator>
	<dc:creator>Yamin, M</dc:creator>
	<dc:creator>Suhendro, Suhendro</dc:creator>
	<dc:creator>Harimurti, Kuntjoro</dc:creator>
	<dc:creator>Immanuel, Suzanna</dc:creator>
	<dc:creator>Majid, Abdul</dc:creator>
	<dc:creator>Elizabeth, Esther</dc:creator>
	<dc:creator>Azali, Chairul N</dc:creator>
	<dc:subject xml:lang="en-US">acute hyperglycemia</dc:subject>
	<dc:subject xml:lang="en-US">AMI</dc:subject>
	<dc:subject xml:lang="en-US">CaMKII</dc:subject>
	<dc:subject xml:lang="en-US">hsCRP</dc:subject>
	<dc:subject xml:lang="en-US">malignant arrhythmias</dc:subject>
	<dc:subject xml:lang="en-US">VLP</dc:subject>
	<dc:description xml:lang="en-US">Background: acute myocardial infarction (AMI) is often followed by hyperglycemia. To date, there is no study that examine the role of myocardial damage, ion channel changes and increased inflammatory response as a pathomechanism of malignant arrhythmias due to hyperglycemia in AMI patients. The aim of this study is to determine the effect of acute hyperglycemia on the occurence of malignant arrhythmias, troponin I, VLP, echocardiographic strain, ion channel changes (CaMKII) and hsCRP. This study also aims to assess the effect of troponin I, VLP, GLS, CaMKII and hsCRP on the occurence of malignant arrhythmias in AMI patients with acute hyperglycemia. Methods: a cross-sectional study followed by a cohort study was conducted on AMI patients treated at ICCU Cipto Mangunkusumo Hospital Jakarta during November 2018 to May 2019 period. Patients with severe infections and who had experienced malignant arrhythmias at admission were excluded from the study. The occurence of malignant arrhythmias as the main outcome of this study and CaMKII level were assessed on the fifth day of treatment. Patients who died before the fifth day of treatment due to causes other than malignant arrhythmias were excluded from analysis. The association between acute hyperglycemia with VLP and the occurence of malignant arrhythmias was analyzed through a chi-square test, whereas the differences between troponin I, GLS, CaMKII and hsCRP, based on the hyperglycemia status of the patient, were analyzed by Mann-Whitney U test. Results: a total of 110 patients were included in the study. Two patients died on the third day of observation due to malignant arrhythmias. No significant relationship was found between acute hyperglycemia in AMI and malignant arrhythmias (RR = 1,38, 95%CI 0.50−3.77). There were differences of CaMKII level on day-1 and day-5 between those who were experienced malignant arrhytmia and those who were not (p-value for differences are 0,03 and 0,01, respectively. In the acute hyperglycemia group, there was difference of CaMKII day-5 levels between positive and negative VLP (p = 0.03). Conclusion: it was concluded that the inititial stage of AMI causes more dominant myocardial damage, as compared to metabolic factors. In the next stage of AMI, acute hyperglycemia increases ROS and the activation of ion channel changes described by CaMKII. This change results in electrophysiological remodeling of the heart, as seen in the VLP image on SA-ECG.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2020-08-07</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/1285</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 52 No. 2 (2020): Acta Medica Indonesiana; 102</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/1285/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>