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The Association of Carcinoembryonic Antigen and Cytokeratin-19 Fragments 21-1 Levels with One-Year Survival of Advanced Non-Small Cell Lung Carcinoma at Cipto Mangunkusumo Hospital: A Retrospective Cohort Study

ACTA MEDICA INDONESIANA · Vol. 52 No. 2 (2020)

ISSN
2338-2732, 0125-9326
Terbit
2020-08-07
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: non-small cell lung carcinoma (NSCLC) is the most common type of lung cancer. Therefore, research into its prognostic factor is very important for better patient management. However, there have been no studies looking for the association of CYFRA 21-1 and CEA with survival of NSCLC in Indonesia, and no cut-off value for them as standardized prognostic factors. This study aims to know the association of CEA and CYFRA 21-1 with one-year survival of advanced stage NSCLC in RSCM and determining their cut-off point as a prognostic factor. Methods: a retrospective cohort study of 111 subjects with advanced stage NSCLC aged > 18 years who were diagnosed from January 2012 to May 2018, resulted in a set of data which includes an initial score of CEA and CYFRA 21-1 at diagnosis, along with their confounding factors, namely performance status (PS), type of histology, therapy, and stadium. All data were taken from the RSCM Medical Record Unit. Results: the CEA area under the curve (AUC) was less than 50% (AUC=0.446) and not significant, whereas AUC CYFRA 21-1=0.741 (0.636–0.847) with p 10.9 ng / mL with a sensitivity of 69.5% and specificity of 65.5%. The variables that met the proportional hazard assumption were CYFRA 21-1, PS, histology, and therapy. CYFRA 21-1 > 10.9 ng/mL had HR 1.744 (HR=1.744; p=0.028); ECOG 3-4 PS had HR 2.434 (HR=2.434; p=0.026); non-adenocarcinoma histology had HR 1.929 (HR=1.929; p=0.029); and the non-chemotherapy group had HR 2.633 (HR=2.633; p=2.633; p=0.015). Conclusion: from both tumour markers, only CYFRA 21-1 was proven to be significant to NSCLC survival. CYFRA 21-1 cut-off value as a prognostic factor was > 10.9 ng/mL.

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Hamzah ShatriAfiliasi tidak diketahui15
Siti SetiatiAfiliasi tidak diketahui8
Sally Aman NasutionAfiliasi tidak diketahui8
Robert SintoAfiliasi tidak diketahui7
Rudi PutrantoAfiliasi tidak diketahui7
Murdani AbdullahAfiliasi tidak diketahui6
Irsan HasanAfiliasi tidak diketahui5
Khie Chen LieAfiliasi tidak diketahui5
Erni Juwita NelwanAfiliasi tidak diketahui5
Juferdy KurniawanAfiliasi tidak diketahui5
Mira YuliantiAfiliasi tidak diketahui4
Em YunirUniversity of Indonesia4
Alvina WidhaniAfiliasi tidak diketahui4
Adityo SusiloAfiliasi tidak diketahui4
Pringgodigdo NugrohoAfiliasi tidak diketahui4
Leonard NainggolanAfiliasi tidak diketahui4
Herikurniawan HerikurniawanAfiliasi tidak diketahui3
Kuntjoro HarimurtiAfiliasi tidak diketahui3
Ari Fahrial SyamAfiliasi tidak diketahui3
Dadang MakmunAfiliasi tidak diketahui3
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Lugyanti SukrismanAfiliasi tidak diketahui2
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Ceva Wicaksono PitoyoAfiliasi tidak diketahui2
Erwin C SusantoAfiliasi tidak diketahui2
Truely P SitorusAfiliasi tidak diketahui2
Evy YunihastutiAfiliasi tidak diketahui2
Rudy HidayatAfiliasi tidak diketahui2
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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The Association of Carcinoembryonic Antigen and Cytokeratin-19 Fragments 21-1 Levels with One-Year Survival of Advanced Non-Small Cell Lung Carcinoma at Cipto Mangunkusumo Hospital: A Retrospective Cohort Study</dc:title>
	<dc:creator>Rumende, Cleopas Martin</dc:creator>
	<dc:creator>Sugianto, Galuh Chandra Kirana</dc:creator>
	<dc:creator>Rinaldi, Ikhwan</dc:creator>
	<dc:creator>Muhadi, Muhadi</dc:creator>
	<dc:subject xml:lang="en-US">lung cancer</dc:subject>
	<dc:subject xml:lang="en-US">non-small cell lung carcinoma</dc:subject>
	<dc:subject xml:lang="en-US">advanced stage</dc:subject>
	<dc:subject xml:lang="en-US">one-year survival</dc:subject>
	<dc:subject xml:lang="en-US">CEA</dc:subject>
	<dc:subject xml:lang="en-US">CYFRA 21-1</dc:subject>
	<dc:description xml:lang="en-US">Background: non-small cell lung carcinoma (NSCLC) is the most common type of lung cancer. Therefore, research into its prognostic factor is very important for better patient management. However, there have been no studies looking for the association of CYFRA 21-1 and CEA with survival of NSCLC in Indonesia, and no cut-off value for them as standardized prognostic factors. This study aims to know the association of CEA and CYFRA 21-1 with one-year survival of advanced stage NSCLC in RSCM and determining their cut-off point as a prognostic factor. Methods: a retrospective cohort study of 111 subjects with advanced stage NSCLC aged &amp;gt; 18 years who were diagnosed from January 2012 to May 2018, resulted in a set of data which includes an initial score of CEA and CYFRA 21-1 at diagnosis, along with their confounding factors, namely performance status (PS), type of histology, therapy, and stadium. All data were taken from the RSCM Medical Record Unit. Results: the CEA area under the curve (AUC) was less than 50% (AUC=0.446) and not significant, whereas AUC CYFRA 21-1=0.741 (0.636–0.847) with p &amp;lt;0.001 was significant in this analysis. CYFRA 21-1 cut-off point was &amp;gt; 10.9 ng / mL with a sensitivity of 69.5% and specificity of 65.5%. The variables that met the proportional hazard assumption were CYFRA 21-1, PS, histology, and therapy. CYFRA 21-1 &amp;gt; 10.9 ng/mL had HR 1.744 (HR=1.744; p=0.028); ECOG 3-4 PS had HR 2.434 (HR=2.434; p=0.026); non-adenocarcinoma histology had HR 1.929 (HR=1.929; p=0.029); and the non-chemotherapy group had HR 2.633 (HR=2.633; p=2.633; p=0.015). Conclusion: from both tumour markers, only CYFRA 21-1 was proven to be significant to NSCLC survival. CYFRA 21-1 cut-off value as a prognostic factor was &amp;gt; 10.9 ng/mL.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2020-08-07</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/1327</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 52 No. 2 (2020): Acta Medica Indonesiana; 140</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/1327/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>