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The Effect of Statin Therapy on Mortality in Adult Patients with Liver Cirrhosis: An Evidence-Based Case Report

ACTA MEDICA INDONESIANA · Vol. 54 No. 3 (2022)

ISSN
2338-2732, 0125-9326
Terbit
2022-09-24
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: Liver cirrhosis causes over one million deaths annually worldwide, but its prognosis varies depending on the presence of complications and decompensating events. Reduction of portal pressure is associated with a reduced risk of mortality in cirrhotic patients. Statin therapy has successfully reduced portal pressure in previous studies, but its effects on overall mortality are unclear. This report aims to determine whether statin therapy significantly affects mortality in patients with liver cirrhosis. Methods: A comprehensive literature search was conducted using five electronic databases: PubMed, Scopus, Embase, Ovid MEDLINE, and Web of Science. Meta-analyses, randomized controlled trials (RCTs), and cohort studies were selected based on pre-set inclusion and exclusion criteria. The quality of selected studies was evaluated using critical appraisal tools developed by the Center for Evidence-Based Medicine. Results: One meta-analysis, one RCT, and one retrospective cohort study were included in this report. The meta-analysis and cohort study were of good quality and reported significantly reduced mortality with statin therapy in cirrhosis patients. However, the RCT had poor validity and did not report a statistically significant difference in mortality between the intervention and control groups. The survival benefits of statins may be limited to Child–Pugh A and B patients only, but this requires confirmation in a larger population of Child–Pugh C patients. Conclusion: Statins potentially reduce mortality in patients with liver cirrhosis, but more evidence is required before they can be widely recommended in clinical practice for this indication.

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Tri Juli Edi TariganUniversity of Indonesia2
Dyah PurnamasariAfiliasi tidak diketahui2
Pradana SoewondoAfiliasi tidak diketahui2
Suharko SoebardiAfiliasi tidak diketahui2
Imam SubektiAfiliasi tidak diketahui2
Dante Saksono HarbuwonoAfiliasi tidak diketahui2
Budiman DarmowidjojoAfiliasi tidak diketahui2
Dicky Levenus TahaparyAfiliasi tidak diketahui2
Farid KurniawanAfiliasi tidak diketahui2
Indrati SuroyoAfiliasi tidak diketahui2
Alvita Dewi SiswoyoAfiliasi tidak diketahui2
Soehartati GondhowiardjoAfiliasi tidak diketahui2
Henry KodratAfiliasi tidak diketahui2
Mardiastuti H WahidAfiliasi tidak diketahui1
Oliver E YausepAfiliasi tidak diketahui1
Sharon Hanmy AngelAfiliasi tidak diketahui1
Angga W LokeswaraAfiliasi tidak diketahui1
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Ignatius Bima PrasetyaAfiliasi tidak diketahui1
Cleopas Martin RumendeAfiliasi tidak diketahui1
Kemas Rakhmat NotarizaAfiliasi tidak diketahui1
Em YunirUniversity of Indonesia1
Lisnawati LisnawatiAfiliasi tidak diketahui1
Erwin Danil YulianAfiliasi tidak diketahui1
Agnes StephanieAfiliasi tidak diketahui1
Benyamin MakesAfiliasi tidak diketahui1
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M SidikAfiliasi tidak diketahui1
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Salmarezka DewiputriAfiliasi tidak diketahui1
Hernawita SuharkoAfiliasi tidak diketahui1
Gusti G SuardanaAfiliasi tidak diketahui1
Vally WulaniAfiliasi tidak diketahui1
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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The Effect of Statin Therapy on Mortality in Adult Patients with Liver Cirrhosis: An Evidence-Based Case Report</dc:title>
	<dc:creator>Agarwal, Raksheeth</dc:creator>
	<dc:creator>Wisnu, Wismandari</dc:creator>
	<dc:subject xml:lang="en-US">Liver cirrhosis</dc:subject>
	<dc:subject xml:lang="en-US">fibrosis</dc:subject>
	<dc:subject xml:lang="en-US">evidence-based medicine</dc:subject>
	<dc:subject xml:lang="en-US">portal pressure</dc:subject>
	<dc:subject xml:lang="en-US">statins</dc:subject>
	<dc:subject xml:lang="en-US">hepatology</dc:subject>
	<dc:description xml:lang="en-US">Background: Liver cirrhosis causes over one million deaths annually worldwide, but its prognosis varies depending on the presence of complications and decompensating events. Reduction of portal pressure is associated with a reduced risk of mortality in cirrhotic patients. Statin therapy has successfully reduced portal pressure in previous studies, but its effects on overall mortality are unclear. This report aims to determine whether statin therapy significantly affects mortality in patients with liver cirrhosis. Methods: A comprehensive literature search was conducted using five electronic databases: PubMed, Scopus, Embase, Ovid MEDLINE, and Web of Science. Meta-analyses, randomized controlled trials (RCTs), and cohort studies were selected based on pre-set inclusion and exclusion criteria. The quality of selected studies was evaluated using critical appraisal tools developed by the Center for Evidence-Based Medicine. Results: One meta-analysis, one RCT, and one retrospective cohort study were included in this report. The meta-analysis and cohort study were of good quality and reported significantly reduced mortality with statin therapy in cirrhosis patients. However, the RCT had poor validity and did not report a statistically significant difference in mortality between the intervention and control groups. The survival benefits of statins may be limited to Child–Pugh A and B patients only, but this requires confirmation in a larger population of Child–Pugh C patients. Conclusion: Statins potentially reduce mortality in patients with liver cirrhosis, but more evidence is required before they can be widely recommended in clinical practice for this indication.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2022-09-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Evidence Based Case Report</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/1352</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 54 No. 3 (2022): Acta Medica Indonesiana; 491</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/1352/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>