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Targeting Inflammation and Immune System in Acute Myocardial Infarction

ACTA MEDICA INDONESIANA · Vol. 51 No. 4 (2020)

ISSN
2338-2732, 0125-9326
Terbit
2020-02-10
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Over more than two decades, the concept of atherosclerosis has developed and lead to inflammatory hypothesis. Inflammation plays an important role on pathogenesis of atherothrombosis and coronary heart disease (CHD), including acute coronary syndrome (ACS). Although the management of ACS has been demonstrated to be beneficial for secondary prevention of coronary heart disease (such as using statin and aspirin) and also seemed to have positive effect on inflammation, the identification of effective management, specifically targeting inflammation, has been not been comprehensively understood.The Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) supported targeting inflammation as a potential effective treatment for chronic coronary heart disease. In the CANTOS study, canakinumab, a monoclonal antibody that inhibits interleukin-1β, reduced the level of hsCRP and caused lower risk of composite endpoint of death due to cardiovascular diseases, myocardial infarct or stroke compared to placebo. However, non-specific anti-inflammatory treatment using methotrexate in the Cardiovascular Inflammation Reduction Trial (CIRT) study did not show any reduced hsCRP and demonstrated that there is no benefit associated with cardiovascular outcomes, which left us with a question whether direct intervention on inflammation could improve cardiovascular outcomes.

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  • Institut Agama Islam Negeri Bone
  • University of Indonesia
  • Hasanuddin University
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Rekan penulisOrganisasiArtikel bersama
Kuntjoro HarimurtiAfiliasi tidak diketahui6
Hamzah ShatriAfiliasi tidak diketahui3
Muhammad YaminInstitut Agama Islam Negeri Bone3
Eka GinanjarAfiliasi tidak diketahui3
Taufik IndrajayaAfiliasi tidak diketahui3
Arif MansjoerAfiliasi tidak diketahui3
Cosphiadi IrawanAfiliasi tidak diketahui2
Ika P WijayaAfiliasi tidak diketahui2
Siti SetiatiAfiliasi tidak diketahui2
Simon SalimAfiliasi tidak diketahui2
Suzanna ImmanuelAfiliasi tidak diketahui2
Aida LydiaAfiliasi tidak diketahui2
Suhendro SuhendroAfiliasi tidak diketahui2
Sally Aman NasutionAfiliasi tidak diketahui2
Em YunirUniversity of Indonesia2
Dita AditianingsihAfiliasi tidak diketahui2
Suhendro SuwartoAfiliasi tidak diketahui2
Lies Dina LiastutiAfiliasi tidak diketahui2
Dedi WihandaAfiliasi tidak diketahui1
E. Mudjaddid E. MudjaddidAfiliasi tidak diketahui1
Teguh SantosoAfiliasi tidak diketahui1
Ardian SaputraHasanuddin University1
Aru W SudoyoAfiliasi tidak diketahui1
Djumhana AtmakusumahAfiliasi tidak diketahui1
Agus KosasihAfiliasi tidak diketahui1
Auda AzizAfiliasi tidak diketahui1
Abdulmuthalib AbdulmuthalibAfiliasi tidak diketahui1
Lyana LyanaAfiliasi tidak diketahui1
Sri InggrianiAfiliasi tidak diketahui1
Merry WinteryAfiliasi tidak diketahui1
Linda LisonAfiliasi tidak diketahui1
Ary H ReksodiputroAfiliasi tidak diketahui1
Faisal YunusAfiliasi tidak diketahui1
Nury NusdwinuringtyasAfiliasi tidak diketahui1
Widjajalaksmi WidjajalaksmiAfiliasi tidak diketahui1
Rahmad IsnantaAfiliasi tidak diketahui1
Marulam M PanggabeanAfiliasi tidak diketahui1
Mulyadi M DjerAfiliasi tidak diketahui1
Nikmah S IdrisAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Targeting Inflammation and Immune System in Acute Myocardial Infarction</dc:title>
	<dc:creator>Alwi, Idrus</dc:creator>
	<dc:subject xml:lang="en-US">inflammation</dc:subject>
	<dc:subject xml:lang="en-US">immune system</dc:subject>
	<dc:subject xml:lang="en-US">acute myocardial infarction</dc:subject>
	<dc:subject xml:lang="en-US">acute coronary syndrome</dc:subject>
	<dc:subject xml:lang="en-US">coronary heart disease</dc:subject>
	<dc:description xml:lang="en-US">Over more than two decades, the concept of atherosclerosis has developed and lead to inflammatory hypothesis. Inflammation plays an important role on pathogenesis of atherothrombosis and coronary heart disease (CHD), including acute coronary syndrome (ACS). Although the management of ACS has been demonstrated to be beneficial for secondary prevention of coronary heart disease (such as using statin and aspirin) and also seemed to have positive effect on inflammation, the identification of effective management, specifically targeting inflammation, has been not been comprehensively understood.The Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) supported targeting inflammation as a potential effective treatment for chronic coronary heart disease. In the CANTOS study, canakinumab, a monoclonal antibody that inhibits interleukin-1β, reduced the level of hsCRP and caused lower risk of composite endpoint of death due to cardiovascular diseases, myocardial infarct or stroke compared to placebo. However, non-specific anti-inflammatory treatment using methotrexate in the Cardiovascular Inflammation Reduction Trial (CIRT) study did not show any reduced hsCRP and demonstrated that there is no benefit associated with cardiovascular outcomes, which left us with a question whether direct intervention on inflammation could improve cardiovascular outcomes.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2020-02-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/1404</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 51 No. 4 (2019): Acta Medica Indonesiana; 287</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/1404/401</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>