Kidney Hyperfiltration After Nephrectomy: A Mechanism to Restore Kidney Function in Living Donors

Marbun, Maruhum Bonar; Susalit, Endang

Jurnal SINTA 1

Kidney Hyperfiltration After Nephrectomy: A Mechanism to Restore Kidney Function in Living Donors

ACTA MEDICA INDONESIANA · Vol. 52 No. 4 (2020)

ISSN: 2338-2732, 0125-9326
Terbit: 2020-12-28
Penerbit: The Indonesian Society of Internal Medicine
Bahasa: eng

Abstrak

Living donor kidney transplantation (LDKT) is the treatment of choice for patients with end stage renal disease (ESRD). Up to now, the studies reporting the impact of nephrectomy in living kidney donors to their future kidney function were limited. Most living donors undergo recovery of kidney function after nephrectomy owing to remnant kidneys’ capability to compensate nephron loss through adaptive hyperfiltration. However, hyperfiltration may fail and turn out to be maladaptive, causing deterioration of donors’ kidney function and increasing risk of chronic kidney disease (CKD) in long term. Hyperfiltration is caused by increased in kidney blood flow and glomerular hypertrophy. Both conditions are regulated by various factors. The adaptive hyperfiltration in the early phase after nephrectomy may play important role in determining long term kidney function, but factors affecting the process are still unclear. Hyperfiltration may also be influenced by donors’ characteristics such as age, body mass index (BMI), family related to the recipient, arterial stiffness and intraoperative intrabdominal pressure. Further study to understand the mechanism of hyperfiltration is needed so that kidney transplant centers could anticipate its failure and the detrimental effects of nephrectomy in the future.

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Rekan penulis	Organisasi	Artikel bersama
Maruhum Bonar H Marbun	Afiliasi tidak diketahui	2
Vidhia Umami	Afiliasi tidak diketahui	1
Bambang Purwanto	Afiliasi tidak diketahui	1
Saptawati Bardosono	Afiliasi tidak diketahui	1
Jacub Pandelaki	Afiliasi tidak diketahui	1
Diana Aulia	Afiliasi tidak diketahui	1

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.

Metadata asli (oai_dc)

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	<dc:title xml:lang="en-US">Kidney Hyperfiltration After Nephrectomy: A Mechanism to Restore Kidney Function in Living Donors</dc:title>
	<dc:creator>Marbun, Maruhum Bonar</dc:creator>
	<dc:creator>Susalit, Endang</dc:creator>
	<dc:subject xml:lang="en-US">Hyperfiltration</dc:subject>
	<dc:subject xml:lang="en-US">Kidney Function</dc:subject>
	<dc:subject xml:lang="en-US">Kidney transplantation</dc:subject>
	<dc:subject xml:lang="en-US">Living donor</dc:subject>
	<dc:subject xml:lang="en-US">Nephrectomy</dc:subject>
	<dc:subject xml:lang="en-US">kidney transplantation</dc:subject>
	<dc:description xml:lang="en-US">Living donor kidney transplantation (LDKT) is the treatment of choice for patients with end stage renal disease (ESRD). Up to now, the studies reporting the impact of nephrectomy in living kidney donors to their future kidney function were limited. Most living donors undergo recovery of kidney function after nephrectomy owing to remnant kidneys’ capability to compensate nephron loss through adaptive hyperfiltration. However, hyperfiltration may fail and turn out to be maladaptive, causing deterioration of donors’ kidney function and increasing risk of chronic kidney disease (CKD) in long term. Hyperfiltration is caused by increased in kidney blood flow and glomerular hypertrophy. Both conditions are regulated by various factors. The adaptive hyperfiltration in the early phase after nephrectomy may play important role in determining long term kidney function, but factors affecting the process are still unclear. Hyperfiltration may also be influenced by donors’ characteristics such as age, body mass index (BMI), family related to the recipient, arterial stiffness and intraoperative intrabdominal pressure. Further study to understand the mechanism of hyperfiltration is needed so that kidney transplant centers could anticipate its failure and the detrimental effects of nephrectomy in the future.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2020-12-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">review</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/1466</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 52 No. 4 (2020): Acta Medica Indonesiana; 413</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/1466/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Acta Medica Indonesiana</dc:rights>
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