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Elevation of Cardiac Biomarkers in COVID-19 As a Major Determinant for Mortality: A Systematic Review

ACTA MEDICA INDONESIANA · Vol. 53 No. 4 (2022)

ISSN
2338-2732, 0125-9326
Terbit
2022-01-10
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: This study aimed to summarize the prognosis of Corona Virus Disease 2019 (COVID-19) patients with elevated troponin and N-terminal pro brain natriuretic peptide (NT-proBNP) levels and demonstrate the involvement of myocardial injury as a complication in COVID-19. Methods: A systematic literature search was performed using several databases (PubMed, MEDLINE, PROQUEST and SCOPUS ) for studies published up to August 2020. Observational studies about the mortality outcome of COVID-19 patients who experienced cardiac injury, as defined by the elevation of serum levels of troponin, brain natriuretic peptide (BNP), with NT-proBNP or only BNP or only NT-proBNP, were included. In addition, a critical appraisal was conducted for all included studies using the Critical Appraisal for Prognostic Studies checklist published by the Centre for Evidence-Based Medicine by the University of Oxford. Results: Seven retrospective observational studies fulfilled the inclusion criteria. This study found that there is a higher risk of death in COVID 19 patients with higher levels of troponin and NT-proBNP, indicating the importance of these biomarkers as determinant factors to predict in-hospital deaths. Conclusion: Based on the analysis, elevation of troponin and NT-proBNP levels plays an essential role in determining the patient prognosis because it is shown to be associated with in-hospital mortality. This also supports the involvement of myocardial injury as a prominent fatal complication in COVID-19.

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Andhika RachmanAfiliasi tidak diketahui4
Yulianto YuliantoAfiliasi tidak diketahui3
Simon SalimAfiliasi tidak diketahui3
Muhammad YaminAfiliasi tidak diketahui3
Kuntjoro HarimurtiAfiliasi tidak diketahui3
Idrus AlwiAfiliasi tidak diketahui3
Arif MansjoerAfiliasi tidak diketahui3
Rudi PutrantoAfiliasi tidak diketahui3
Sally Aman NasutionAfiliasi tidak diketahui3
Ika Prasetya WijayaAfiliasi tidak diketahui2
Siti SetiatiAfiliasi tidak diketahui2
Annisa Puspitasari NachrowiAfiliasi tidak diketahui2
Hamzah ShatriAfiliasi tidak diketahui2
Zahra Nuril AnwarAfiliasi tidak diketahui2
Evy YunihastutiAfiliasi tidak diketahui2
Alvina WidhaniAfiliasi tidak diketahui2
Anshari Saifuddin HasibuanAfiliasi tidak diketahui2
Sukamto KoesnoeAfiliasi tidak diketahui2
Wawan SetyawanAfiliasi tidak diketahui1
Suzanna ImmanuelAfiliasi tidak diketahui1
Aida LydiaAfiliasi tidak diketahui1
Taufik IndrajayaAfiliasi tidak diketahui1
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M Hafiz AiniAfiliasi tidak diketahui1
Ni Made HustriniAfiliasi tidak diketahui1
M Shiddiq Al HanifAfiliasi tidak diketahui1
Dono AntonoAfiliasi tidak diketahui1
Putri ZulmiyusriniAfiliasi tidak diketahui1
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Alexander Edo TondasAfiliasi tidak diketahui1
M Syahrir AziziAfiliasi tidak diketahui1
Rubiana SukardiAfiliasi tidak diketahui1
Em YunirUniversity of Indonesia1
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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Elevation of Cardiac Biomarkers in COVID-19 As a Major Determinant for Mortality: A Systematic Review</dc:title>
	<dc:creator>Hermansyah, Tracy Anabella</dc:creator>
	<dc:creator>Ginanjar, Eka</dc:creator>
	<dc:creator>Putri, Valerie Hirsy</dc:creator>
	<dc:subject xml:lang="en-US">COVID-19</dc:subject>
	<dc:subject xml:lang="en-US">myocardial injury</dc:subject>
	<dc:subject xml:lang="en-US">troponin</dc:subject>
	<dc:subject xml:lang="en-US">BNP</dc:subject>
	<dc:subject xml:lang="en-US">NT-proBNP</dc:subject>
	<dc:subject xml:lang="en-US">prognostic factors</dc:subject>
	<dc:description xml:lang="en-US">Background: This study aimed to summarize the prognosis of Corona Virus Disease 2019 (COVID-19) patients with elevated troponin and N-terminal pro brain natriuretic peptide (NT-proBNP) levels and demonstrate the involvement of myocardial injury as a complication in COVID-19. Methods: A systematic literature search was performed using several databases (PubMed, MEDLINE, PROQUEST and SCOPUS ) for studies published up to August 2020. Observational studies about the mortality outcome of COVID-19 patients who experienced cardiac injury, as defined by the elevation of serum levels of troponin, brain natriuretic peptide (BNP), with NT-proBNP or only BNP or only NT-proBNP, were included. In addition, a critical appraisal was conducted for all included studies using the Critical Appraisal for Prognostic Studies checklist published by the Centre for Evidence-Based Medicine by the University of Oxford. Results: Seven retrospective observational studies fulfilled the inclusion criteria. This study found that there is a higher risk of death in COVID 19 patients with higher levels of troponin and NT-proBNP, indicating the importance of these biomarkers as determinant factors to predict in-hospital deaths. Conclusion: Based on the analysis, elevation of troponin  and NT-proBNP levels plays an essential role in determining the patient prognosis because it is shown to be associated with in-hospital mortality. This also supports the involvement of myocardial injury as a prominent fatal complication in COVID-19.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2022-01-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/1597</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 53 No. 4 (2021): Acta Medica Indonesiana; 385</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/1597/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>