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Wound Healing in Diabetic Foot Ulcer Patients Using Combined Use of Platelet Rich Fibrin and Hyaluronic Acid, Platelet Rich Fibrin and Placebo: An Open Label, Randomized Controlled Trial

ACTA MEDICA INDONESIANA · Vol. 53 No. 3 (2021)

ISSN
2338-2732, 0125-9326
Terbit
2021-10-04
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: Autologous platelet-rich fibrin (A-PRF) is an adjunctive method for diabetic foot ulcer (DFU) in addition to glycaemic control and debridement. This study aimed to evaluate the role of A-PRF + hyaluronic acid (HA), A-PRF and sodium chloride 0.9% (control) in DFU wound healing. Nowaday, the use of PRF autologous consider as adjuvant therapy in DFU treatment. Methods: This open-label randomized controlled trial was conducted at Koja District Hospital and Gatot Soebroto Hospital from July 2019 to April 2020. DFU patients with wound duration of three months, Wagner-2, and ulcer size < 40 cm2 were recruited and randomly assigned into A-PRF + AH, A-PRF and control group. On day-0, day-3 and day -7, samples and photographs were taken. Samples were analysed with ELISA and photographs were analysed with ImageJ to calculate granulation index (GI). Statistical analysis was performed using SPSS version 20. Results: Topical therapy with A-PRF + AH was associated with a significant increase in VEGF from day 0 (232.8 pg/mg) vs day 7 (544.5 pg/mg) compared to A-PRF on day 0 (185.7 pg/mg) vs day 7 (272.8 pg/mg), and the controls on day 0 (183.7 pg/mg) vs day 7 (167.4 pg/mg). On evaluation of VEGF swab, there is increasing significantly in A-PRF+HA group compare others group in day -3 ( p=0.022) and day -7 (p= 0.001).In the A-PRF + AH group, there was a significant decrease in IL-6 from day 0 (106.4 pg/mg) vs day 7 (88.7 pg/mg) compared with PRF on day 0 (91.9 pg/mg) vs day 7 (48,8 pg/mg). IL-6 was increased in the control group from day 0 (125.3 pg/mg) vs day 7 (167.9 pg/mg). On evaluation of IL-6 swab, there is decreasing significantly in A-PRF+HA group compare others group in day -7 (p= 0.041). Conclusion: The PRF + HA combination increased angiogenesis and reduced inflammation in DFUs and may represent a new DFU therapy.

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  • University of Indonesia
  • Institut Agama Islam Negeri Bone
  • Universitas Teknologi Sumbawa
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Rekan penulisOrganisasiArtikel bersama
Kuntjoro HarimurtiAfiliasi tidak diketahui7
Hamzah ShatriAfiliasi tidak diketahui7
Tri Juli Edi TariganUniversity of Indonesia4
Imam SubektiAfiliasi tidak diketahui4
Eka GinanjarAfiliasi tidak diketahui4
Taufik IndrajayaAfiliasi tidak diketahui4
Arif MansjoerAfiliasi tidak diketahui4
Siti SetiatiAfiliasi tidak diketahui4
Suhendro SuwartoAfiliasi tidak diketahui4
Muhammad YaminInstitut Agama Islam Negeri Bone3
Cleopas Martin RumendeAfiliasi tidak diketahui3
Cosphiadi IrawanAfiliasi tidak diketahui3
Suzanna ImmanuelAfiliasi tidak diketahui3
Dita AditianingsihAfiliasi tidak diketahui3
Rudi PutrantoAfiliasi tidak diketahui3
Ika P WijayaAfiliasi tidak diketahui2
Ika Prasetya WijayaAfiliasi tidak diketahui2
Simon SalimAfiliasi tidak diketahui2
Aida LydiaAfiliasi tidak diketahui2
Lisnawati LisnawatiUniversitas Teknologi Sumbawa2
Indrati SuroyoAfiliasi tidak diketahui2
Suhendro SuhendroAfiliasi tidak diketahui2
Sally Aman NasutionAfiliasi tidak diketahui2
Lies Dina LiastutiAfiliasi tidak diketahui2
Pradana SoewondoAfiliasi tidak diketahui2
Maruhum Bonar H MarbunAfiliasi tidak diketahui2
Dadang MakmunAfiliasi tidak diketahui2
Iris RengganisAfiliasi tidak diketahui2
Raden Irawati IsmailAfiliasi tidak diketahui2

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Wound Healing in Diabetic Foot Ulcer Patients Using Combined Use of Platelet Rich Fibrin and Hyaluronic Acid, Platelet Rich Fibrin and Placebo: An Open Label, Randomized Controlled Trial</dc:title>
	<dc:creator>Kartika, Ronald Winardi</dc:creator>
	<dc:creator>Alwi, Idrus</dc:creator>
	<dc:creator>Suyatna, Franciscus D</dc:creator>
	<dc:creator>Yunir, Em</dc:creator>
	<dc:creator>Waspadji, Sarwono</dc:creator>
	<dc:creator>Immanuel, Suzana</dc:creator>
	<dc:creator>Bardosono, Saptawati</dc:creator>
	<dc:creator>Sungkar, Saleha</dc:creator>
	<dc:creator>Rachmat, Jusuf</dc:creator>
	<dc:creator>Hediyati, Mirta</dc:creator>
	<dc:creator>Silalahi, Todung</dc:creator>
	<dc:subject xml:lang="en-US">diabetic foot ulcer</dc:subject>
	<dc:subject xml:lang="en-US">platelet-rich fibrin</dc:subject>
	<dc:subject xml:lang="en-US">hyaluronic acid</dc:subject>
	<dc:subject xml:lang="en-US">endocrinology</dc:subject>
	<dc:description xml:lang="en-US">Background: Autologous platelet-rich fibrin (A-PRF) is an adjunctive method for diabetic foot ulcer (DFU) in addition to glycaemic control and debridement. This study aimed to evaluate the role of A-PRF + hyaluronic acid (HA), A-PRF and sodium chloride 0.9% (control) in DFU wound healing. Nowaday, the use of  PRF autologous consider as adjuvant therapy in DFU treatment. Methods: This open-label randomized controlled trial was conducted at Koja District Hospital and Gatot Soebroto Hospital from July 2019 to April 2020. DFU patients with wound duration of three months, Wagner-2, and ulcer size &amp;lt; 40 cm2 were recruited and randomly assigned into A-PRF + AH, A-PRF and control group. On day-0, day-3 and day -7, samples and photographs were taken. Samples were analysed with ELISA and photographs were analysed with ImageJ to calculate granulation index (GI). Statistical analysis was performed using SPSS version 20. Results: Topical therapy with A-PRF + AH was associated with a significant increase in VEGF from day 0 (232.8 pg/mg) vs day 7 (544.5 pg/mg) compared to A-PRF on day 0 (185.7 pg/mg) vs day 7 (272.8 pg/mg), and the controls on day 0 (183.7 pg/mg) vs day 7 (167.4 pg/mg). On evaluation  of VEGF swab, there is increasing significantly in A-PRF+HA group compare others group in day -3 ( p=0.022) and day -7 (p= 0.001).In the A-PRF + AH group, there was a significant decrease in IL-6 from day 0 (106.4 pg/mg) vs day 7 (88.7 pg/mg) compared with PRF on day 0 (91.9 pg/mg) vs day 7 (48,8 pg/mg). IL-6 was increased in the control group from day 0 (125.3 pg/mg) vs day 7 (167.9 pg/mg). On evaluation  of IL-6 swab, there is decreasing significantly in A-PRF+HA group compare others group in day -7 (p= 0.041). Conclusion: The PRF + HA combination increased angiogenesis and reduced inflammation in DFUs and may represent a new DFU therapy.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2021-10-04</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">RCT open label</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/1601</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 53 No. 3 (2021): Acta Medica Indonesiana; 268</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/1601/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2021 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>