The Validation of Drug Resistance in Pneumonia (DRIP) Score in Predicting Infections due to Drug-Resistant Pathogens in Community-acquired Pneumonia at Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Fadrian, Fadrian; Chen, Khie; Kumalawati, July; Rumende, Cleopas M; Shatri, Hamzah; Nelwan, Erni J

Jurnal SINTA 1

The Validation of Drug Resistance in Pneumonia (DRIP) Score in Predicting Infections due to Drug-Resistant Pathogens in Community-acquired Pneumonia at Cipto Mangunkusumo Hospital, Jakarta, Indonesia

ACTA MEDICA INDONESIANA · Vol. 53 No. 4 (2022)

ISSN: 2338-2732, 0125-9326
Terbit: 2022-01-10
Penerbit: The Indonesian Society of Internal Medicine
Bahasa: eng

Abstrak

Background: The emergence of drug-resistant pathogens (DRP) in recent years possibly contributes to the common problems associated with community-acquired pneumonia. However, to predict the risk of the ailment, the DRIP score is mainly applied, although no validation study has been reported in Indonesia. Therefore, the score prediction accuracy in the population, patient characteristics and germ patterns appears indefinite, particularly for Cipto Mangunkusumo Hospital, Jakarta. The purpose of this study is to determine the DRIP performance as an instrument in predicting infections due to drug-resistant pathogens (DRP) in community-acquired pneumonia at Cipto Mangunkusumo Hospital. Methods: This research employed a cross-sectional design, where the subjects were community-acquired pneumonia patients treated between January 2019 and June 2020. In addition, adequate medical records of the participants were obtained. The condition is defined as DRP when the sputum culture results show resistance to non-pseudomonal β-lactam antibiotics, macrolides, and respiratory fluoroquinolones. Furthermore, the score performance was analyzed by determining the calibration and discrimination values, using the Hosmer-Lemeshow test and AUROC, respectively. Results: A total of 254 subjects were known to have satisfied the selection criteria. These participants were categorized into DRP and non-DRP groups, with 103 (40.6%) and 151 (59.4%) patients, correspondingly. The DRIP calibration analysis using the Hosmer-Lemeshow test obtained p-value = 0.001 (p <0.05), while an AUC value of 0.759 (CI 95%, 0.702-0.810) was derived from the ROC curve. However, at a score of ≥ 4, the DRIP showed sensitivity, specificity, positive and negative predictive values of 70.9, 92.7, 86.9, and 82.3%, respectively. Conclusion: The DRIP score demonstrated a significant performance in predicting infections due to DRP in community-acquired pneumonia.

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Rekan penulis	Organisasi	Artikel bersama
Rudi Putranto	Afiliasi tidak diketahui	23
Edward Faisal	Afiliasi tidak diketahui	10
Siti Setiati	Afiliasi tidak diketahui	9
Ikhwan Rinaldi	Afiliasi tidak diketahui	8
Cleopas Martin Rumende	Afiliasi tidak diketahui	8
Murdani Abdullah	Afiliasi tidak diketahui	7
Iris Rengganis	Afiliasi tidak diketahui	6
Kuntjoro Harimurti	Afiliasi tidak diketahui	6
Dadang Makmun	Afiliasi tidak diketahui	5
Imam Subekti	Afiliasi tidak diketahui	4
Em Yunir	University of Indonesia	4
Pringgodigdo Nugroho	Afiliasi tidak diketahui	4
Idrus Alwi	Afiliasi tidak diketahui	4
Cosphiadi Irawan	Afiliasi tidak diketahui	4
Achmad Fauzi	Afiliasi tidak diketahui	4
Leonard Nainggolan	Afiliasi tidak diketahui	4
Dina Elita	Afiliasi tidak diketahui	3
Raden Irawati Ismail	Afiliasi tidak diketahui	3
Rahajeng N Tunjungputri	Afiliasi tidak diketahui	3
Rudy Hidayat	Afiliasi tidak diketahui	3
Alvina Widhani	Afiliasi tidak diketahui	3
Yanuar Ardani	Afiliasi tidak diketahui	3
Vinandia Irvianita	Afiliasi tidak diketahui	3
Robert Sinto	Afiliasi tidak diketahui	3
Ari Fahrial Syam	Afiliasi tidak diketahui	3
Dono Antono	Afiliasi tidak diketahui	2
Herdiman T Pohan	Afiliasi tidak diketahui	2
Suhendro Suhendro	Afiliasi tidak diketahui	2
Mizanul Adli	Afiliasi tidak diketahui	2
Ika P Wijaya	Afiliasi tidak diketahui	2
Gurmeet Singh	Afiliasi tidak diketahui	2
Dyah Purnamasari	Afiliasi tidak diketahui	2
Ika Prasetya Wijaya	Afiliasi tidak diketahui	2
Suzanna Immanuel	Afiliasi tidak diketahui	2

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Metadata asli (oai_dc)

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	<dc:title xml:lang="en-US">The Validation of Drug Resistance in Pneumonia (DRIP) Score in Predicting Infections due to Drug-Resistant Pathogens in Community-acquired Pneumonia at Cipto Mangunkusumo Hospital, Jakarta, Indonesia</dc:title>
	<dc:creator>Fadrian, Fadrian</dc:creator>
	<dc:creator>Chen, Khie</dc:creator>
	<dc:creator>Kumalawati, July</dc:creator>
	<dc:creator>Rumende, Cleopas M</dc:creator>
	<dc:creator>Shatri, Hamzah</dc:creator>
	<dc:creator>Nelwan, Erni J</dc:creator>
	<dc:subject xml:lang="en-US">DRIP score</dc:subject>
	<dc:subject xml:lang="en-US">resistant pathogens</dc:subject>
	<dc:subject xml:lang="en-US">community-acquired pneumonia</dc:subject>
	<dc:description xml:lang="en-US">Background: The emergence of drug-resistant pathogens (DRP) in recent years possibly contributes to the common problems associated with community-acquired pneumonia. However, to predict the risk of the ailment, the DRIP score is mainly applied, although no validation study has been reported in Indonesia. Therefore, the score prediction accuracy in the population, patient characteristics and germ patterns appears indefinite, particularly for Cipto Mangunkusumo Hospital, Jakarta. The purpose of this study is to determine the DRIP performance as an instrument in predicting infections due to drug-resistant pathogens (DRP) in community-acquired pneumonia at Cipto Mangunkusumo Hospital. Methods: This research employed a cross-sectional design, where the subjects were community-acquired pneumonia patients treated between January 2019 and June 2020. In addition, adequate medical records of the participants were obtained. The condition is defined as DRP when the sputum culture results show resistance to non-pseudomonal β-lactam antibiotics, macrolides, and respiratory fluoroquinolones. Furthermore, the score performance was analyzed by determining the calibration and discrimination values, using the Hosmer-Lemeshow test and AUROC, respectively. Results: A total of 254 subjects were known to have satisfied the selection criteria. These participants were categorized into DRP and non-DRP groups, with 103 (40.6%) and 151 (59.4%) patients, correspondingly. The DRIP calibration analysis using the Hosmer-Lemeshow test obtained p-value = 0.001 (p &amp;lt;0.05), while an AUC value of 0.759 (CI 95%, 0.702-0.810) was derived from the ROC curve. However, at a score of ≥ 4, the DRIP showed sensitivity, specificity, positive and negative predictive values of 70.9, 92.7, 86.9, and 82.3%, respectively. Conclusion: The DRIP score demonstrated a significant performance in predicting infections due to DRP in community-acquired pneumonia.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2022-01-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/1824</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 53 No. 4 (2021): Acta Medica Indonesiana; 416</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/1824/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Fadrian Fadrian</dc:rights>
</oai_dc:dc>