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Effectiveness of Convalescent Plasma Therapy in Treating COVID-19: an Evidence-based Case Report

ACTA MEDICA INDONESIANA · Vol. 53 No. 4 (2022)

ISSN
2338-2732, 0125-9326
Terbit
2022-01-10
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: Convalescent plasma is a potentially beneficial, tolerable, and available additional treatment option for COVID-19. This study aims to evaluate whether the administration of convalescent plasma therapy leads to improved clinical outcomes in COVID-19 patients compared to standard medical therapy. Methods: We conducted a search of Pubmed, Cochrane, and EBSCO for studies assessing the clinical question using inclusion and exclusion criteria. Selected studies were critically appraised, and the results were summarized. Results: A meta-analysis of 10 randomized clinical trials (RCTs), an RCT, a case-control clinical study were selected and assessed. Only the case-control clinical study showed that convalescent plasma administration improved the clinical outcomes of patients with COVID-19, including all-cause mortality, hospital length of stay, and the need for mechanical ventilation. On the contrary, the other two studies of a higher level of evidence showed no significant clinical outcome improvement with convalescent plasma therapy. Conclusion: The effectiveness of convalescent plasma therapy in improving clinical outcomes of patients with COVID-19 was still inconclusive due to several study limitations and other possible causes.

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  • National Research and Innovation Agency
  • Universitas Merdeka Madiun
  • State University of Semarang
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Rekan penulisOrganisasiArtikel bersama
Cleopas Martin RumendeAfiliasi tidak diketahui8
Siti SetiatiAfiliasi tidak diketahui6
Ceva Wicaksono PitoyoAfiliasi tidak diketahui5
Moses Mazmur AsafAfiliasi tidak diketahui3
Kuntjoro HarimurtiAfiliasi tidak diketahui3
Vally WulaniAfiliasi tidak diketahui3
Aziza HarrisAfiliasi tidak diketahui3
Ceva W PitoyoAfiliasi tidak diketahui2
Reyhan Eddy YunusAfiliasi tidak diketahui2
Wita SeptiyantiAfiliasi tidak diketahui2
Jessica MarsigitAfiliasi tidak diketahui2
Adityo SusiloAfiliasi tidak diketahui2
Nur AtikahAfiliasi tidak diketahui1
Hasan MaulahelaAfiliasi tidak diketahui1
Rahmat CahyanurAfiliasi tidak diketahui1
Wuryantoro WuryantoroUniversitas Merdeka Madiun1
Hamzah ShatriAfiliasi tidak diketahui1
Zulkifli AminAfiliasi tidak diketahui1
Valy WulaniAfiliasi tidak diketahui1
Cleopas M RumendeAfiliasi tidak diketahui1
Rabbinu R PribadiAfiliasi tidak diketahui1
Anindita Kartika WiraputriAfiliasi tidak diketahui1
Michael Aaron RomuloAfiliasi tidak diketahui1
Imam SubektiAfiliasi tidak diketahui1
Setiabakti AndrianAfiliasi tidak diketahui1
Sedjahtera AlbertAfiliasi tidak diketahui1
Moses M AsafAfiliasi tidak diketahui1
Puji AstutiState University of Semarang1
Muhammad K AzwarAfiliasi tidak diketahui1
Eka Dian SafitriAfiliasi tidak diketahui1
Respati W RanakusumaAfiliasi tidak diketahui1
Siti Rizny F SaldiAfiliasi tidak diketahui1
Cut Yulia Indah SariAfiliasi tidak diketahui1
Rahmi IstantiAfiliasi tidak diketahui1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Effectiveness of Convalescent Plasma Therapy in Treating COVID-19: an Evidence-based Case Report</dc:title>
	<dc:creator>Yulianti, Mira</dc:creator>
	<dc:creator>Johan, Christian</dc:creator>
	<dc:creator>Singh, Gurmeet</dc:creator>
	<dc:creator>Tenda, Eric Daniel</dc:creator>
	<dc:creator>Herikurniawan, Herikurniawan</dc:creator>
	<dc:creator>Wijaya, I Putu Eka Krisnha</dc:creator>
	<dc:subject xml:lang="en-US">convalescent plasma</dc:subject>
	<dc:subject xml:lang="en-US">coronavirus</dc:subject>
	<dc:subject xml:lang="en-US">COVID-19</dc:subject>
	<dc:subject xml:lang="en-US">SARS-CoV-2</dc:subject>
	<dc:subject xml:lang="en-US">COVID-19</dc:subject>
	<dc:subject xml:lang="en-US">pulmonology</dc:subject>
	<dc:subject xml:lang="en-US">infectious diseases</dc:subject>
	<dc:description xml:lang="en-US">Background: Convalescent plasma is a potentially beneficial, tolerable, and available additional treatment option for COVID-19. This study aims to evaluate whether the administration of convalescent plasma therapy leads to improved clinical outcomes in COVID-19 patients compared to standard medical therapy. Methods: We conducted a search of Pubmed, Cochrane, and EBSCO for studies assessing the clinical question using inclusion and exclusion criteria. Selected studies were critically appraised, and the results were summarized. Results: A meta-analysis of 10 randomized clinical trials (RCTs), an RCT, a case-control clinical study were selected and assessed. Only the case-control clinical study showed that convalescent plasma administration improved the clinical outcomes of patients with COVID-19, including all-cause mortality, hospital length of stay, and the need for mechanical ventilation. On the contrary, the other two studies of a higher level of evidence showed no significant clinical outcome improvement with convalescent plasma therapy. Conclusion: The effectiveness of convalescent plasma therapy in improving clinical outcomes of patients with COVID-19 was still inconclusive due to several study limitations and other possible causes.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2022-01-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Evidence-based case report</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/1856</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 53 No. 4 (2021): Acta Medica Indonesiana; 497</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/1856/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Christian Johan, Mira Yulianti, Gurmeet Singh, Eric Daniel Tenda, Herikurniawan Herikurniawan, I Putu Eka Krisnha Wijaya</dc:rights>
</oai_dc:dc>