Correlation of Moxifloxacin Concentration, C-Reactive Protein, and Inflammatory Cytokines on QTc Interval in Rifampicin-Resistant Tuberculosis Patients Treated with Shorter Regimens

Kusmiati, Tutik; Mertaniasih, Ni Made; Putranto, Johanes Nugroho Eko; Suprapti, Budi; Luthfah, Nadya; Soedarsono, Soedarsono; Koesoemoprodjo, Winariani; Sari, Aryani Prawita

Jurnal SINTA 1

Correlation of Moxifloxacin Concentration, C-Reactive Protein, and Inflammatory Cytokines on QTc Interval in Rifampicin-Resistant Tuberculosis Patients Treated with Shorter Regimens

ACTA MEDICA INDONESIANA · Vol. 54 No. 1 (2022)

ISSN: 2338-2732, 0125-9326
Terbit: 2022-04-08
Penerbit: The Indonesian Society of Internal Medicine
Bahasa: eng

Abstrak

Background: Drug-resistant tuberculosis (DR-TB) is a global health concern. QTc prolongation is a serious adverse effect in DR-TB patients receiving a shorter regimen. This study aimed to evaluate the correlation of moxifloxacin concentration, CRP, and inflammatory cytokines with QTc interval in DR-TB patients treated with a shorter regimen. Methods: This study was performed in 2 groups of rifampicin-resistant (RR-TB) patients receiving shorter regimens. Correlation for all variables was analyzed. Results: CRP, IL-1β, and QTc baseline showed significant differences between 45 RR-TB patients on intensive phase and continuation phase with p-value of <0.001, 0.040, and <0.001, respectively. TNF-α and IL-6 between RR-TB patients on intensive phase and continuation phase showed no significant difference with p=0.530 and 0.477, respectively. CRP, TNF-α, IL-1 β, and IL-6 did not correlate with QTc interval in intensive phase (p=0.226, 0.281, 0.509, and 0.886, respectively), and also in continuation phase (0.805, 0.865, 0.406, 0.586, respectively). At 2 hours after taking the 48th-dose, moxifloxacin concentration did not correlate with QTc interval, both in intensive phase (p=0.576) and in continuation phase (p=0.691). At 1 hour before taking the 72nd-hour dose, moxifloxacin concentration also did not correlate with QTc interval in intensive phase (p=0.531) and continuation phase (p=0.209). Conclusion: Moxifloxacin concentration, CRP, and inflammatory cytokines did not correlate with QTc interval in RR-TB patients treated with shorter regimens. The use of moxifloxacin is safe but should be routinely monitored and considered the presence of other risk factors for QTc prolongation in RR-TB patients who received shorter regimens.

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University of Brawijaya
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Rekan penulis	Organisasi	Artikel bersama
Putu Dyah Widyaningsih	Afiliasi tidak diketahui	2
Muhamad Frendy Setyawan	Afiliasi tidak diketahui	2
Cholichul Hadi	Afiliasi tidak diketahui	2
Ni Njoman Juliasih	Afiliasi tidak diketahui	2
Reny Mareta Sari	Afiliasi tidak diketahui	2
Ilham Nur Alfian	Afiliasi tidak diketahui	2
Tiffany Tiara Pakasi	Afiliasi tidak diketahui	2
Muchamad Ali Syafaat	Afiliasi tidak diketahui	1
Nadir Nadir	University of Brawijaya	1
Jazim Hamidi	University of Brawijaya	1

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.

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	<dc:title xml:lang="en-US">Correlation of Moxifloxacin Concentration, C-Reactive Protein, and Inflammatory Cytokines on QTc Interval  in Rifampicin-Resistant Tuberculosis Patients Treated with Shorter Regimens</dc:title>
	<dc:creator>Kusmiati, Tutik</dc:creator>
	<dc:creator>Mertaniasih, Ni Made</dc:creator>
	<dc:creator>Putranto, Johanes Nugroho Eko</dc:creator>
	<dc:creator>Suprapti, Budi</dc:creator>
	<dc:creator>Luthfah, Nadya</dc:creator>
	<dc:creator>Soedarsono, Soedarsono</dc:creator>
	<dc:creator>Koesoemoprodjo, Winariani</dc:creator>
	<dc:creator>Sari, Aryani Prawita</dc:creator>
	<dc:subject xml:lang="en-US">pulmonology</dc:subject>
	<dc:subject xml:lang="en-US">tropical disease</dc:subject>
	<dc:subject xml:lang="en-US">infection</dc:subject>
	<dc:description xml:lang="en-US">Background: Drug-resistant tuberculosis (DR-TB) is a global health concern. QTc prolongation is a serious adverse effect in DR-TB patients receiving a shorter regimen. This study aimed to evaluate the correlation of moxifloxacin concentration, CRP, and inflammatory cytokines with QTc interval in DR-TB patients treated with a shorter regimen. Methods: This study was performed in 2 groups of rifampicin-resistant (RR-TB) patients receiving shorter regimens. Correlation for all variables was analyzed. Results: CRP, IL-1β, and QTc baseline showed significant differences between 45 RR-TB patients on intensive phase and continuation phase with p-value of &amp;lt;0.001, 0.040, and &amp;lt;0.001, respectively. TNF-α and IL-6 between RR-TB patients on intensive phase and continuation phase showed no significant difference with p=0.530 and 0.477, respectively. CRP, TNF-α, IL-1 β, and IL-6 did not correlate with QTc interval in intensive phase (p=0.226, 0.281, 0.509, and 0.886, respectively), and also in continuation phase (0.805, 0.865, 0.406, 0.586, respectively). At 2 hours after taking the 48th-dose, moxifloxacin concentration did not correlate with QTc interval, both in intensive phase (p=0.576) and in continuation phase (p=0.691). At 1 hour before taking the 72nd-hour dose, moxifloxacin concentration also did not correlate with QTc interval in intensive phase (p=0.531) and continuation phase (p=0.209). Conclusion: Moxifloxacin concentration, CRP, and inflammatory cytokines did not correlate with QTc interval in RR-TB patients treated with shorter regimens. The use of moxifloxacin is safe but should be routinely monitored and considered the presence of other risk factors for QTc prolongation in RR-TB patients who received shorter regimens.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2022-04-08</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/1913</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 54 No. 1 (2022): Acta Medica Indonesiana; 19</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/1913/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Tutik Kusmiati, Ni Made Mertaniasih, Johanes Nugroho Eko Putranto, Budi Suprapti, Nadya Luthfah, Soedarsono Soedarsono, Winariani Koesoemoprodjo, Aryani Prawita Sari</dc:rights>
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