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COVID-19 Associated Pulmonary Aspergillosis: A Case Series

ACTA MEDICA INDONESIANA · Vol. 54 No. 2 (2022)

ISSN
2338-2732, 0125-9326
Terbit
2022-07-07
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Coronavirus disease 2019 (COVID-19) has been a worldwide pandemic with several problems, one of which is the lack of definitive treatment. COVID-19-associated pulmonary aspergillosis (CAPA), the presence of invasive pulmonary aspergillosis (IPA) in COVID-19 patients, is one of the concerning secondary infections associated with higher mortality and worse clinical outcomes. Diagnosing CAPA may be challenging due to the possible absence of classic host factors and clinical symptoms or obscured radiological findings. We described two CAPA cases, which were suspected due to persistent respiratory failure despite standard treatment of COVID-19 with additional therapies and antimicrobial agents for secondary infections, eventually diagnosed with serum galactomannan testing. Clinical conditions of both patients improved significantly after the administration of voriconazole. This case series emphasizes the importance of being aware of clinical suspicions indicating CAPA followed by galactomannan testing as a relatively fast, noninvasive test for its diagnosis, which leads to appropriate antifungal treatment.

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  • National Research and Innovation Agency
  • Universitas Merdeka Madiun
  • State University of Semarang
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Rekan penulisOrganisasiArtikel bersama
Cleopas Martin RumendeAfiliasi tidak diketahui8
Siti SetiatiAfiliasi tidak diketahui6
Ceva Wicaksono PitoyoAfiliasi tidak diketahui5
Moses Mazmur AsafAfiliasi tidak diketahui3
Kuntjoro HarimurtiAfiliasi tidak diketahui3
Vally WulaniAfiliasi tidak diketahui3
Aziza HarrisAfiliasi tidak diketahui3
Ceva W PitoyoAfiliasi tidak diketahui2
Reyhan Eddy YunusAfiliasi tidak diketahui2
Wita SeptiyantiAfiliasi tidak diketahui2
Jessica MarsigitAfiliasi tidak diketahui2
Adityo SusiloAfiliasi tidak diketahui2
Nur AtikahAfiliasi tidak diketahui1
Hasan MaulahelaAfiliasi tidak diketahui1
Rahmat CahyanurAfiliasi tidak diketahui1
Wuryantoro WuryantoroUniversitas Merdeka Madiun1
Hamzah ShatriAfiliasi tidak diketahui1
Zulkifli AminAfiliasi tidak diketahui1
Valy WulaniAfiliasi tidak diketahui1
Cleopas M RumendeAfiliasi tidak diketahui1
Rabbinu R PribadiAfiliasi tidak diketahui1
Anindita Kartika WiraputriAfiliasi tidak diketahui1
Michael Aaron RomuloAfiliasi tidak diketahui1
Imam SubektiAfiliasi tidak diketahui1
Setiabakti AndrianAfiliasi tidak diketahui1
Sedjahtera AlbertAfiliasi tidak diketahui1
Moses M AsafAfiliasi tidak diketahui1
Puji AstutiState University of Semarang1
Muhammad K AzwarAfiliasi tidak diketahui1
Eka Dian SafitriAfiliasi tidak diketahui1
Respati W RanakusumaAfiliasi tidak diketahui1
Siti Rizny F SaldiAfiliasi tidak diketahui1
Cut Yulia Indah SariAfiliasi tidak diketahui1
Rahmi IstantiAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">COVID-19 Associated Pulmonary Aspergillosis:  A Case Series</dc:title>
	<dc:creator>Yulianti, Mira</dc:creator>
	<dc:creator>Johan, Christian</dc:creator>
	<dc:creator>Tenda, Eric Daniel</dc:creator>
	<dc:creator>Singh, Gurmeet</dc:creator>
	<dc:creator>Herikurniawan, Herikurniawan</dc:creator>
	<dc:creator>Wijaya, I Putu Eka Krisnha</dc:creator>
	<dc:subject xml:lang="en-US">Aspergillosis</dc:subject>
	<dc:subject xml:lang="en-US">Aspergillus</dc:subject>
	<dc:subject xml:lang="en-US">COVID-19</dc:subject>
	<dc:subject xml:lang="en-US">COVID-19-associated pulmonary aspergillosis (CAPA)</dc:subject>
	<dc:subject xml:lang="en-US">invasive pulmonary aspergillosis (IPA)</dc:subject>
	<dc:subject xml:lang="en-US">CO</dc:subject>
	<dc:subject xml:lang="en-US">pulmonology</dc:subject>
	<dc:subject xml:lang="en-US">infectious diseasesVID-19</dc:subject>
	<dc:description xml:lang="en-US">Coronavirus disease 2019 (COVID-19) has been a worldwide pandemic with several problems, one of which is the lack of definitive treatment. COVID-19-associated pulmonary aspergillosis (CAPA), the presence of invasive pulmonary aspergillosis (IPA) in COVID-19 patients, is one of the concerning secondary infections associated with higher mortality and worse clinical outcomes. Diagnosing CAPA may be challenging due to the possible absence of classic host factors and clinical symptoms or obscured radiological findings. We described two CAPA cases, which were suspected due to persistent respiratory failure despite standard treatment of COVID-19 with additional therapies and antimicrobial agents for secondary infections, eventually diagnosed with serum galactomannan testing. Clinical conditions of both patients improved significantly after the administration of voriconazole. This case series emphasizes the importance of being aware of clinical suspicions indicating CAPA followed by galactomannan testing as a relatively fast, noninvasive test for its diagnosis, which leads to appropriate antifungal treatment.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2022-07-07</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Case series</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/1996</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 54 No. 2 (2022): Acta Medica Indonesiana; 292</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/1996/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Mira Yulianti, Christian Johan, Eric Daniel Tenda, Gurmeet Singh, Herikurniawan Herikurniawan, I Putu Eka Krisnha Wijaya</dc:rights>
</oai_dc:dc>