The Association Between Uric Acid and Symmetric Dimethylarginine Levels in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis

Pradwipa, Rizki Yaruntradhani; Hustrini, Ni Made; Hidayat, Rudy; Shatri, Hamzah

Jurnal SINTA 1

The Association Between Uric Acid and Symmetric Dimethylarginine Levels in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis

ACTA MEDICA INDONESIANA · Vol. 54 No. 3 (2022)

ISSN: 2338-2732, 0125-9326
Terbit: 2022-09-24
Penerbit: The Indonesian Society of Internal Medicine
Bahasa: eng

Abstrak

Background: Uric acid (UA) levels are associated with increased risk of cardiovascular events and mortality in hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients. In a study with a population of healthy young adults and HD there was a correlation between high blood uric acid levels and blood symmetric dimethylarginine (SDMA) level. However, in CAPD population, there are still conflicting data on the mechanism of increased risks related to uric acid levels. This study aimed to assess the association between uric acid levels and SDMA in the subjects undergoing CAPD. Methods: This was a cross – sectional study conducted in all the adults who underwent CAPD for at least three months in tertiary hospital in Jakarta, Indonesia. Subjects already on uric lowering therapy, pregnant or lactating women, and those with a history of malignancy were excluded. Uric acid and SDMA level were measured at the same time patients controlled to outpatient clinic. Bivariate analysis was performed using the Mann – Whitney test and multivariate analysis performed using logistic regression test. Results: A total of 55 subjects were included. The median level of UA was 7.30 + 1.59 mg/dl and 33 subjects (60%) had UA levels of 7 mg/dl or higher. The median SDMA level was 633.73 + 231.54 ng/mL. Subjects with UA levels > 7 mg/dl had significantly higher SDMA levels compared to subjects with UA levels < 7 mg/dl (721.58 + 220.57 vs 501.95 + 182; P < 0.001). The cut – off value of SDMA 536 ng/mL was obtained from the receiver operating characteristic (ROC) curve with sensitivity 81.8%, specificity 63.6%, PPV 77.78% and NPV 73.68%. After fully adjusted with the confounders, the determinant factors in this study were diabetes mellitus (OR: 7.844; CI95%: 1.899 – 32.395: P value: 0.004) and dyslipidemia (OR: 6.440; CI95%: 1.483 – 27.970; P value: 0.013) as risk factors. Conclusion: In CAPD patients, UA levels above 7 mg/dl were associated with increased SDMA levels. This study demonstrates the determinant factors regarding association between UA level and SDMA in CAPD patients were diabetes mellitus and dyslipidemia. The cut – off value of SDMA above 536 ng/mL were significant to increased risk of cardiovascular events.

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Rekan penulis	Organisasi	Artikel bersama
Rudi Putranto	Afiliasi tidak diketahui	24
Edward Faisal	Afiliasi tidak diketahui	10
Ikhwan Rinaldi	Afiliasi tidak diketahui	10
Siti Setiati	Afiliasi tidak diketahui	10
Murdani Abdullah	Afiliasi tidak diketahui	8
Cleopas Martin Rumende	Afiliasi tidak diketahui	7
Pringgodigdo Nugroho	Afiliasi tidak diketahui	5
Iris Rengganis	Afiliasi tidak diketahui	4
Imam Subekti	Afiliasi tidak diketahui	4
Em Yunir	University of Indonesia	4
Dadang Makmun	Afiliasi tidak diketahui	4
Dina Elita	Afiliasi tidak diketahui	4
Kuntjoro Harimurti	Afiliasi tidak diketahui	4
Alvina Widhani	Afiliasi tidak diketahui	4
Sally Aman Nasution	Afiliasi tidak diketahui	4
Ari Fahrial Syam	Afiliasi tidak diketahui	4
Eka Ginanjar	Afiliasi tidak diketahui	4
Andhika Rachman	Afiliasi tidak diketahui	4
Idrus Alwi	Afiliasi tidak diketahui	3
Cosphiadi Irawan	Afiliasi tidak diketahui	3
Raden Irawati Ismail	Afiliasi tidak diketahui	3
Yanuar Ardani	Afiliasi tidak diketahui	3
Vinandia Irvianita	Afiliasi tidak diketahui	3
Achmad Fauzi	Afiliasi tidak diketahui	3
Pradana Soewondo	Afiliasi tidak diketahui	3
Irsan Hasan	Afiliasi tidak diketahui	3
Arif Mansjoer	Afiliasi tidak diketahui	3
Dono Antono	Afiliasi tidak diketahui	2
Parlindungan Siregar	Afiliasi tidak diketahui	2
Ginova Nainggolan	Afiliasi tidak diketahui	2
Mizanul Adli	Afiliasi tidak diketahui	2
Ratih Arianita Agung	Afiliasi tidak diketahui	2
Vera Abdullah	Afiliasi tidak diketahui	2
Petrin R Lukman	Afiliasi tidak diketahui	2
Suhendro Suwarto	Afiliasi tidak diketahui	2
Saskia Aziza Nursyirwan	Afiliasi tidak diketahui	2

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Metadata asli (oai_dc)

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	<dc:title xml:lang="en-US">The Association Between Uric Acid and Symmetric Dimethylarginine Levels in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis</dc:title>
	<dc:creator>Pradwipa, Rizki Yaruntradhani</dc:creator>
	<dc:creator>Hustrini, Ni Made</dc:creator>
	<dc:creator>Hidayat, Rudy</dc:creator>
	<dc:creator>Shatri, Hamzah</dc:creator>
	<dc:subject xml:lang="en-US">uric acid</dc:subject>
	<dc:subject xml:lang="en-US">SDMA</dc:subject>
	<dc:subject xml:lang="en-US">CAPD</dc:subject>
	<dc:description xml:lang="en-US">Background: Uric acid (UA) levels are associated with increased risk of cardiovascular events and mortality in hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients. In a study with a population of healthy young adults and HD there was a correlation between high blood uric acid levels and blood symmetric dimethylarginine (SDMA) level. However, in CAPD population, there are still conflicting data on the mechanism of increased risks related to uric acid levels. This study aimed to assess the association between uric acid levels and SDMA in the subjects undergoing CAPD. Methods: This was a cross – sectional study conducted in all the adults who underwent CAPD for at least three months in tertiary hospital in Jakarta, Indonesia. Subjects already on uric lowering therapy, pregnant or lactating women, and those with a history of malignancy were excluded. Uric acid and SDMA level were measured at the same time patients controlled to outpatient clinic. Bivariate analysis was performed using the Mann – Whitney test and multivariate analysis performed using logistic regression test. Results: A total of 55 subjects were included. The median level of UA was 7.30 + 1.59 mg/dl and 33 subjects (60%) had UA levels of 7 mg/dl or higher. The median SDMA level was 633.73 + 231.54 ng/mL. Subjects with UA levels &amp;gt; 7 mg/dl had significantly higher SDMA levels compared to subjects with UA levels &amp;lt; 7 mg/dl (721.58 + 220.57 vs 501.95 + 182; P &amp;lt; 0.001). The cut – off value of SDMA 536 ng/mL was obtained from the receiver operating characteristic (ROC) curve with sensitivity 81.8%, specificity 63.6%, PPV 77.78% and NPV 73.68%. After fully adjusted with the confounders, the determinant factors in this study were diabetes mellitus (OR: 7.844; CI95%: 1.899 – 32.395: P value: 0.004) and dyslipidemia (OR: 6.440; CI95%: 1.483 – 27.970; P value: 0.013) as risk factors. Conclusion: In CAPD patients, UA levels above 7 mg/dl were associated with increased SDMA levels. This study demonstrates the determinant factors regarding association between UA level and SDMA in CAPD patients were diabetes mellitus and dyslipidemia. The cut – off value of SDMA above 536 ng/mL were significant to increased risk of cardiovascular events.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2022-09-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2013</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 54 No. 3 (2022): Acta Medica Indonesiana; 365</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2013/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Rizki Yaruntradhani Pradwipa</dc:rights>
</oai_dc:dc>