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Revisiting the Overlooked Infection: Rickettsioses

ACTA MEDICA INDONESIANA · Vol. 54 No. 4 (2023)

ISSN
2338-2732, 0125-9326
Terbit
2023-01-10
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

The prevalence of human Rickettsioses cases in Indonesia is unknown and could probably be underestimated. The high prevalence of seropositive Rickettsia sp. was reported in small mammals (as vectors) and humans. In Indonesia, a recent study in patients with acute fever revealed that the prevalence of Rickettsioses is 10%. Many cases of Rickettsioses were often misdiagnosed with dengue fever, enteric fever, or leptospirosis due to their overlapping clinical manifestation. The limitation of point of care testing in Indonesia hindered the adequacy of diagnosis confirmation. Appropriate empirical or definitive treatment with macrolide, mainly doxycycline, is preferable compared to other broad-spectrum antibiotics, such as cephalosporin or quinolones. Moreover, when left untreated, Rickettsioses may deteriorate progressively to fatal outcomes, such as meningitis, sepsis, and even death. The awareness of health care practitioners, the availability of confirmatory rapid diagnostic tests and adequate treatment choices are important in eradicating this disease.

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Revisiting the Overlooked Infection: Rickettsioses</dc:title>
	<dc:creator>Lie, Khie Chen</dc:creator>
	<dc:creator>Nelwan, Erni Juwita</dc:creator>
	<dc:creator>Pasaribu, Adeline</dc:creator>
	<dc:creator>Shakinah, Sharifah</dc:creator>
	<dc:creator>Sinto, Robert</dc:creator>
	<dc:creator>Nainggolan, Leonard</dc:creator>
	<dc:subject xml:lang="en-US">internal medicine</dc:subject>
	<dc:subject xml:lang="en-US">tropical disease</dc:subject>
	<dc:subject xml:lang="en-US">infection</dc:subject>
	<dc:subject xml:lang="en-US">rickettsioses</dc:subject>
	<dc:subject xml:lang="en-US">tropical infectious disease</dc:subject>
	<dc:description xml:lang="en-US">The prevalence of human Rickettsioses cases in Indonesia is unknown and could probably be underestimated. The high prevalence of seropositive Rickettsia sp. was reported in small mammals (as vectors) and humans. In Indonesia, a recent study in patients with acute fever revealed that the prevalence of Rickettsioses is 10%. Many cases of Rickettsioses were often misdiagnosed with dengue fever, enteric fever, or leptospirosis due to their overlapping clinical manifestation. The limitation of point of care testing in Indonesia hindered the adequacy of diagnosis confirmation. Appropriate empirical or definitive treatment with macrolide, mainly doxycycline, is preferable compared to other broad-spectrum antibiotics, such as cephalosporin or quinolones. Moreover, when left untreated, Rickettsioses may deteriorate progressively to fatal outcomes, such as meningitis, sepsis, and even death. The awareness of health care practitioners, the availability of confirmatory rapid diagnostic tests and adequate treatment choices are important in eradicating this disease.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2023-01-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2068</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 54 No. 4 (2022): Acta Medica Indonesiana; 647</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2068/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Khie Chen Lie, Erni Juwita Nelwan, Adeline Pasaribu, Sharifah Shakinah, Robert Sinto, Leonard Nainggolan</dc:rights>
</oai_dc:dc>