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Effect of Cholecalciferol Supplementation on Disease Activity and Quality of Life of Systemic Lupus Erythematosus Patients: A Randomized Clinical Trial Study

ACTA MEDICA INDONESIANA · Vol. 54 No. 3 (2022)

ISSN
2338-2732, 0125-9326
Terbit
2022-09-24
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: Increase in the prevalence and survival rates has led to the assessment of disease activity and quality of life of SLE patients as targets in treatment. Cholecalciferol was considered as having a role in reducing disease activity and improving quality of life. Methods: A double blind, randomized, controlled trial was conducted on female outpatients aged 18-60 years with SLE, consecutively recruited from September to December 2021 at Cipto Mangunkusumo Hospital. Sixty subjects who met the research criteria were randomized and equally assigned into the cholecalciferol and placebo groups. The study outcomes were measured at baseline and after 12 weeks of intervention. Results: Out of 60 subjects, 27 subjects in cholecalciferol group and 25 subjects in placebo group completed the intervention. There was a significant improvement on the level of vitamin D (ng/ml) after intervention in the cholecalciferol group, from an average of 15,69 ng/ml (8.1-28.2) to 49,90 ng/ml (26-72.1), and for the placebo group from 15,0 ng/ml (8.1-25,0) to 17.35 ng/ml (8.1-48.3) (p<0,000). Results of the MEX-SLEDAI score showed significant differences in both groups after the intervention, with a significant decrease in the cholecalciferol group from 2,67 (0-11) to 1,37 (0-6), compared to the placebo group from 2,6 (0-6) to 2,48 (0-6) (p<0,001). There were no significant differences on the quality of life in both groups. Conclusion: Supplementation of cholecalciferol 5000 IU/day for 12 weeks was statistically significant in increasing vitamin D levels and improving disease activity, but did not significantly improve the quality of life of SLE patients.

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  • University of Indonesia
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Rekan penulisOrganisasiArtikel bersama
Edward FaisalAfiliasi tidak diketahui19
Siti SetiatiAfiliasi tidak diketahui16
Ikhwan RinaldiAfiliasi tidak diketahui14
Cleopas Martin RumendeAfiliasi tidak diketahui14
Sukamto KoesnoeAfiliasi tidak diketahui13
Murdani AbdullahAfiliasi tidak diketahui12
Anshari Saifuddin HasibuanAfiliasi tidak diketahui12
Suzy MariaAfiliasi tidak diketahui10
Kuntjoro HarimurtiAfiliasi tidak diketahui10
Imam SubektiAfiliasi tidak diketahui10
Pringgodigdo NugrohoAfiliasi tidak diketahui10
Em YunirUniversity of Indonesia8
Samsuridjal DjauziAfiliasi tidak diketahui8
Raden Irawati IsmailAfiliasi tidak diketahui8
Eka GinanjarAfiliasi tidak diketahui8
Evy YunihastutiAfiliasi tidak diketahui7
Pradana SoewondoAfiliasi tidak diketahui7
Dina ElitaAfiliasi tidak diketahui7
Teguh Harjono KarjadiAfiliasi tidak diketahui7
Sally Aman NasutionAfiliasi tidak diketahui7
Cosphiadi IrawanAfiliasi tidak diketahui6
Rudy HidayatAfiliasi tidak diketahui6
Yanuar ArdaniAfiliasi tidak diketahui6
Vinandia IrvianitaAfiliasi tidak diketahui6
Dadang MakmunAfiliasi tidak diketahui5
Idrus AlwiAfiliasi tidak diketahui5
Agus Joko SusantoAfiliasi tidak diketahui4
Cleopas M RumendeAfiliasi tidak diketahui4
Wismandari WisnuAfiliasi tidak diketahui4
Irsan HasanAfiliasi tidak diketahui4
Arif MansjoerAfiliasi tidak diketahui4
Dono AntonoAfiliasi tidak diketahui3
Dicky Levenus TahaparyAfiliasi tidak diketahui3

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Effect of Cholecalciferol Supplementation on Disease Activity and Quality of Life of Systemic Lupus Erythematosus Patients: A Randomized Clinical Trial Study</dc:title>
	<dc:creator>Fiblia, Fiblia</dc:creator>
	<dc:creator>Rengganis, Iris</dc:creator>
	<dc:creator>Purnamasari, Dyah</dc:creator>
	<dc:creator>Widhani, Alvina</dc:creator>
	<dc:creator>Karjadi, Teguh H</dc:creator>
	<dc:creator>Shatri, Hamzah</dc:creator>
	<dc:creator>Putranto, Rudi</dc:creator>
	<dc:subject xml:lang="en-US">cholecalciferol</dc:subject>
	<dc:subject xml:lang="en-US">disease activity</dc:subject>
	<dc:subject xml:lang="en-US">quality of life</dc:subject>
	<dc:subject xml:lang="en-US">systemic lupus erythematosus</dc:subject>
	<dc:subject xml:lang="en-US">internal medicine subject</dc:subject>
	<dc:description xml:lang="en-US">Background: Increase in the prevalence and survival rates has led to the assessment of disease activity and quality of life of SLE patients as targets in treatment. Cholecalciferol was considered as having a role in reducing disease activity and improving quality of life. Methods: A double blind, randomized, controlled trial was conducted on female  outpatients aged 18-60 years with SLE, consecutively recruited from September to December 2021 at Cipto Mangunkusumo Hospital. Sixty subjects who met the research criteria were randomized and equally assigned into the cholecalciferol and placebo groups. The study outcomes were measured at baseline and after 12 weeks of intervention. Results: Out of 60 subjects, 27 subjects in cholecalciferol group and 25 subjects in placebo group completed the intervention. There was a significant improvement on the level of vitamin D (ng/ml) after intervention in the cholecalciferol group, from an average of 15,69 ng/ml (8.1-28.2) to 49,90 ng/ml (26-72.1), and for the placebo group from 15,0 ng/ml (8.1-25,0) to 17.35 ng/ml (8.1-48.3) (p&amp;lt;0,000). Results of the MEX-SLEDAI score showed significant differences in both groups after the intervention, with a significant decrease in the cholecalciferol group from 2,67 (0-11) to 1,37 (0-6), compared to the placebo group from 2,6 (0-6) to  2,48 (0-6) (p&amp;lt;0,001). There were no significant differences on the quality of life in both groups. Conclusion: Supplementation of cholecalciferol 5000 IU/day for 12 weeks was statistically significant in increasing vitamin D levels and improving disease activity, but did not significantly improve the quality of life of SLE patients.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2022-09-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Randomized control trial, double blind</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2074</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 54 No. 3 (2022): Acta Medica Indonesiana; 406</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2074/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 fiblia fiblia fiblia, iris rengganis -, dyah Purnamasari Irawan, alvina widhani -, Teguh H Karjadi, Hamzah Shatri -, Rudi Putranto -</dc:rights>
</oai_dc:dc>