Melola Discovery

← Melola Discovery

Jurnal SINTA 1

Diagnosis of Chronic Lymphocytic Leukemia Using iwCLL 2018 Compared with NCI-WG96 Criteria in Cipto Mangunkusumo Hospital: A Practical Consideration in Resource Limited Setting

ACTA MEDICA INDONESIANA · Vol. 54 No. 4 (2023)

ISSN
2338-2732, 0125-9326
Terbit
2023-01-10
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: The diagnosis of chronic lymphocytic leukemia (CLL) is mainly based on blood count, morphology, and immunophenotyping. In Indonesia, the diagnosis is more challenging as the availability of immunophenotyping tests is limited. The European Society of Medical Oncology (ESMO) stated flowcytometry as a prerequisite to establishing diagnosis of CLL, meanwhile in the original International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2018 criteria, which has been widely accepted by physicians caring for patients with CLL, the diagnosis of CLL can be made in patients with cytopenia using bone marrow biopsy where flowcytometry test is not available. The aim of the study was to compare the utility of International Workshop on Chronic Lymphocytic Leukemia 2018 [iwCLL 2018 (2)] compared with National Cancer Institute Working Group 96 (NCI-WG96) criteria in the diagnosis of CLL in Indonesia, especially in limited resource settings. Methods: The data of newly diagnosed CLL patients, including baseline demographic, clinical, and laboratory characteristics was retrieved retrospectively from medical records in Cipto Mangunkusumo General Hospital from 2015 until 2021. Diagnosis of CLL using iwCLL 2018 diagnostic criteria were then compared with National Cancer Institute Working Group 96 (NCI-WG96) criteria. Results: Thirty-eight patients were enrolled to this study. The median age was 59.5 years and dominated by males. Most of them were classified in the late-stage disease (63.4% in Binet C and about 70% in Rai III-IV). Four cases were CD5-negative CLL. Based on NCI-WG96 guideline, only 24 patients (63.2%) fulfilled all four criteria for CLL. Similarly, using the iwCLL 2018 flowcytometric criteria without biopsy data, 26 patients (68%) were diagnosed as CLL. However, if bone marrow biopsy in patient with cytopenia was taken into account, all patients (100%) can be confirmed as CLL. Conclusion: The iwCLL 2018 criteria which included bone marrow biopsy in the presence of cytopenia was more applicable to establish the diagnosis of CLL in Indonesia where flowcytometry is not available.

Kata kunci

Jaringan kolaborasi para penulis

40 penulis · 230 tautan kepenulisan bersama · menampilkan 40 yang paling banyak terhubung

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Hamzah ShatriAfiliasi tidak diketahui8
Cleopas Martin RumendeAfiliasi tidak diketahui5
Andhika RachmanAfiliasi tidak diketahui5
Siti SetiatiAfiliasi tidak diketahui4
Robert SintoAfiliasi tidak diketahui4
Alvina WidhaniAfiliasi tidak diketahui4
Sally Aman NasutionAfiliasi tidak diketahui4
Rudi PutrantoAfiliasi tidak diketahui3
Irsan HasanAfiliasi tidak diketahui3
Murdani AbdullahAfiliasi tidak diketahui3
Karmel L TambunanAfiliasi tidak diketahui3
Rudy HidayatAfiliasi tidak diketahui3
Ina S TimanAfiliasi tidak diketahui2
Muhadi MuhadiAfiliasi tidak diketahui2
Dadang MakmunAfiliasi tidak diketahui2
Juferdy KurniawanAfiliasi tidak diketahui2
Pringgodigdo NugrohoAfiliasi tidak diketahui2
Evy YunihastutiAfiliasi tidak diketahui2
Simon SalimAfiliasi tidak diketahui2
Nurul Inayah RahmaniAfiliasi tidak diketahui2
Chyntia Olivia Maurine JasirwanAfiliasi tidak diketahui2
Khie Chen LieAfiliasi tidak diketahui2
Suryo Anggoro Kusumo WibowoAfiliasi tidak diketahui2
Erni Juwita NelwanAfiliasi tidak diketahui2
Noto DwimartutieAfiliasi tidak diketahui2
Arini SetiawatiAfiliasi tidak diketahui2
T. Djumhana AtmakusumaAfiliasi tidak diketahui2
Shufrie EffendiAfiliasi tidak diketahui2
Ika Prasetya WijayaAfiliasi tidak diketahui2
Maruhum Bonar Hasiholan MarbunAfiliasi tidak diketahui2
Eka GinanjarAfiliasi tidak diketahui2
Andri Maruli T LubisAfiliasi tidak diketahui1
Kurniadi HusodoAfiliasi tidak diketahui1
Djajadiman GatotAfiliasi tidak diketahui1
Muchtaruddin MansyurAfiliasi tidak diketahui1
Al RasyidAfiliasi tidak diketahui1
Jusuf MisbachAfiliasi tidak diketahui1
Jan S PurbaAfiliasi tidak diketahui1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Diagnosis of Chronic Lymphocytic Leukemia Using iwCLL 2018 Compared with  NCI-WG96 Criteria in Cipto Mangunkusumo Hospital: A Practical Consideration in Resource Limited Setting</dc:title>
	<dc:creator>Sukrisman, Lugyanti</dc:creator>
	<dc:creator>Rinaldi, Ikhwan</dc:creator>
	<dc:subject xml:lang="en-US">chronic lymphocytic leukemia</dc:subject>
	<dc:subject xml:lang="en-US">epidemiology</dc:subject>
	<dc:subject xml:lang="en-US">NCI-WG96 criteria</dc:subject>
	<dc:subject xml:lang="en-US">IWCLL 2018 criteria</dc:subject>
	<dc:description xml:lang="en-US">Background: The diagnosis of chronic lymphocytic leukemia (CLL) is mainly based on blood count, morphology, and immunophenotyping. In Indonesia, the diagnosis is more challenging as the availability of immunophenotyping tests is limited. The European Society of Medical Oncology (ESMO) stated flowcytometry as a prerequisite to establishing diagnosis of CLL, meanwhile in the original International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2018 criteria, which has been widely accepted by physicians caring for patients with CLL,  the diagnosis of CLL can be made in patients with cytopenia using bone marrow biopsy where flowcytometry test is not available. The aim of the study was to compare the utility of International Workshop on Chronic Lymphocytic Leukemia 2018 [iwCLL 2018 (2)] compared with National Cancer Institute Working Group 96 (NCI-WG96) criteria in the diagnosis of CLL in Indonesia, especially in limited resource settings. Methods: The data of newly diagnosed CLL patients, including baseline demographic, clinical, and laboratory characteristics was retrieved retrospectively from medical records in Cipto Mangunkusumo General Hospital from 2015 until 2021. Diagnosis of CLL  using iwCLL 2018 diagnostic criteria were then compared with National Cancer Institute Working Group 96 (NCI-WG96) criteria.  Results: Thirty-eight patients were enrolled to this study. The median age was 59.5 years and dominated by males. Most of them were classified in the late-stage disease (63.4% in Binet C and about 70% in Rai III-IV). Four cases were CD5-negative CLL. Based on NCI-WG96 guideline, only 24 patients (63.2%) fulfilled all four criteria for CLL. Similarly, using the iwCLL 2018 flowcytometric criteria without biopsy data, 26 patients (68%) were diagnosed as CLL.   However, if bone marrow biopsy in patient with cytopenia was taken into account, all patients (100%) can be confirmed as CLL. Conclusion: The iwCLL 2018 criteria which included bone marrow biopsy in the presence of cytopenia was more applicable to establish the diagnosis of CLL in Indonesia where flowcytometry is not available.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2023-01-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2120</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 54 No. 4 (2022): Acta Medica Indonesiana; 531</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2120/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Lugyanti Sukrisman, Ikhwan Rinaldi</dc:rights>
</oai_dc:dc>