Melola Discovery

← Melola Discovery

Jurnal SINTA 1

Diagnostic Performance of Mac-2-Binding Protein Glycosylation Isomer (M2BPGi), compared to Transient Elastography to Assess Liver Stiffness in Treatment Naïve Chronic Hepatitis C Patients

ACTA MEDICA INDONESIANA · Vol. 54 No. 4 (2023)

ISSN
2338-2732, 0125-9326
Terbit
2023-01-10
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: Liver fibrosis is an essential factor in the management of Hepatitis C virus infection. Its assessment is crucial in decision-making regarding the therapeutic decisions, and the patients’ follow up. However, the established liver measurement methods have several limitations. Therefore, this study aims to assess the role of Mac-2-Binding Protein Glycosylation Isomer (M2BPGi) as a novel biomarker to measure liver stiffness in treatment naïve Chronic Hepatitis C Indonesian patients. Methods: This study used a cross-sectional design to determine the correlation between serum M2BPGi and the degree of liver stiffness, Transient Elastrography, and differences in serum M2BPGi levels in chronic hepatitis C patients. Serum M2BPGi level and Transient Elastography results were evaluated in 56 Chronic Hepatitis C patients and 48 healthy controls. Pearson correlation analysis was conducted to find the correlation between the level of M2BPGi and Transient Elastography result. ROC analysis was conducted to find the optimum cut-off to assess fibrosis’s degree among Chronic Hepatitis C Patients. Results: The level of serum M2BPGi and Transient Elastography result was strongly correlated with the median level of serum M2BPGi. It was also significantly higher among Chronic Hepatitis C Patients than among healthy controls (r: 0.708, p<0.001; 0.590 COI vs. 4.130 COI, p<0.001). Among the Chronic Hepatitis C patients, the median serum of M2BPGi increased according to the degree of liver fibrosis: 1.500 COI (F0-F1), 2.985 COI (F2-F3) and 8.785 COI (≥F4). The optimum cut-off value for diagnosing significant fibrosis (F2-F3) was 1.820 COI (AUC: 90.8%) and for diagnosing cirrhosis (≥F4) was 3.770 COI (AUC: 89.3%). Conclusion: Serum M2BPGi was a reliable diagnostic tool for identifying liver fibrosis in Indonesian patients with Chronic Hepatitis C.

Kata kunci

Jaringan kolaborasi para penulis

40 penulis · 305 tautan kepenulisan bersama · menampilkan 40 yang paling banyak terhubung

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Gita ApriliciaAfiliasi tidak diketahui11
Andri SanityosoAfiliasi tidak diketahui9
Ikhwan RinaldiAfiliasi tidak diketahui9
Lutfie LutfieAfiliasi tidak diketahui8
Marcellus SimadibrataAfiliasi tidak diketahui6
Cosmas Rinaldi Adithya LesmanaAfiliasi tidak diketahui6
Muhammad Begawan BestariAfiliasi tidak diketahui6
Pringgodigdo NugrohoAfiliasi tidak diketahui6
Siti SetiatiAfiliasi tidak diketahui5
Hamzah ShatriAfiliasi tidak diketahui5
Kuntjoro HarimurtiAfiliasi tidak diketahui4
Sally Aman NasutionAfiliasi tidak diketahui4
Evy YunihastutiAfiliasi tidak diketahui4
Rudi PutrantoAfiliasi tidak diketahui4
Cleopas Martin RumendeAfiliasi tidak diketahui4
Hery Djagat PurnomoAfiliasi tidak diketahui4
Alvina WidhaniAfiliasi tidak diketahui3
Rino A GaniAfiliasi tidak diketahui3
Leonard NainggolanAfiliasi tidak diketahui3
Ni Made HustriniAfiliasi tidak diketahui3
Murdani AbdullahAfiliasi tidak diketahui3
Eka GinanjarAfiliasi tidak diketahui3
Dyah PurnamasariAfiliasi tidak diketahui3
Teguh Harjono KarjadiAfiliasi tidak diketahui2
Esthika DewiastyAfiliasi tidak diketahui2
Purwita Wijaya LaksmiAfiliasi tidak diketahui2
Muhadi MuhadiAfiliasi tidak diketahui2
Dadang MakmunAfiliasi tidak diketahui2
Robert SintoAfiliasi tidak diketahui2
Suryo Anggoro Kusumo WibowoAfiliasi tidak diketahui2

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Diagnostic Performance of Mac-2-Binding Protein Glycosylation Isomer (M2BPGi), compared to Transient Elastography to Assess Liver Stiffness in Treatment Naïve Chronic Hepatitis C Patients</dc:title>
	<dc:creator>Sulaiman, Andri Sanityoso</dc:creator>
	<dc:creator>Hasan, Irsan</dc:creator>
	<dc:creator>Lesmana, Cosmas Rinaldi A</dc:creator>
	<dc:creator>Kurniawan, Juferdy</dc:creator>
	<dc:creator>Jasirwan, Chyntia Olivia Maurine</dc:creator>
	<dc:creator>Nababan, Saut</dc:creator>
	<dc:creator>Kalista, Kemal Fariz</dc:creator>
	<dc:creator>Hanifa, Rachmadianti Sukma</dc:creator>
	<dc:creator>Rachmani, Desti</dc:creator>
	<dc:creator>Gani, Rino Alvani</dc:creator>
	<dc:subject xml:lang="en-US">Chronic Hepatitis C</dc:subject>
	<dc:subject xml:lang="en-US">Mac-2-Binding Protein Glycosylation Isomer</dc:subject>
	<dc:subject xml:lang="en-US">Transient Elastography</dc:subject>
	<dc:subject xml:lang="en-US">Liver</dc:subject>
	<dc:subject xml:lang="en-US">Hepatobiliary</dc:subject>
	<dc:subject xml:lang="en-US">chronic Hepatitis C</dc:subject>
	<dc:description xml:lang="en-US">Background: Liver fibrosis is an essential factor in the management of Hepatitis C virus infection. Its assessment is crucial in decision-making regarding the therapeutic decisions, and the patients’ follow up. However, the established liver measurement methods have several limitations. Therefore, this study aims to assess the role of Mac-2-Binding Protein Glycosylation Isomer (M2BPGi) as a novel biomarker to measure liver stiffness in treatment naïve Chronic Hepatitis C Indonesian patients. Methods: This study used a cross-sectional design to determine the correlation between serum M2BPGi and the degree of liver stiffness, Transient Elastrography, and differences in serum M2BPGi levels in chronic hepatitis C patients. Serum M2BPGi level and Transient Elastography results were evaluated in 56 Chronic Hepatitis C patients and 48 healthy controls. Pearson correlation analysis was conducted to find the correlation between the level of M2BPGi and Transient Elastography result. ROC analysis was conducted to find the optimum cut-off to assess fibrosis’s degree among Chronic Hepatitis C Patients. Results: The level of serum M2BPGi and Transient Elastography result was strongly correlated with the median level of serum M2BPGi. It was also significantly higher among Chronic Hepatitis C Patients than among healthy controls (r: 0.708, p&amp;lt;0.001; 0.590 COI vs. 4.130 COI, p&amp;lt;0.001). Among the Chronic Hepatitis C patients, the median serum of M2BPGi increased according to the degree of liver fibrosis: 1.500 COI (F0-F1), 2.985 COI (F2-F3) and 8.785 COI (≥F4). The optimum cut-off value for diagnosing significant fibrosis (F2-F3) was 1.820 COI (AUC: 90.8%) and for diagnosing cirrhosis (≥F4) was 3.770 COI (AUC: 89.3%). Conclusion: Serum M2BPGi was a reliable diagnostic tool for identifying liver fibrosis in Indonesian patients with Chronic Hepatitis C.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2023-01-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Original article, diagnostic method</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2168</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 54 No. 4 (2022): Acta Medica Indonesiana; 567</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2168/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Andri Sanityoso Sulaiman</dc:rights>
</oai_dc:dc>