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The Effect of Vitamin D Supplementation on Symptoms of Depression in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

ACTA MEDICA INDONESIANA · Vol. 54 No. 4 (2023)

ISSN
2338-2732, 0125-9326
Terbit
2023-01-10
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: The effect of vitamin D supplementation on depressive symptoms in people with type 2 diabetes is still up for debate. The aim of this paper was to investigate the effect of vitamin D supplementation on symptoms of depression in type 2 diabetic patients. Methods: The protocol for this review has been registered in PROSPERO:CRD42021231713. Searching for literature was conducted using Pubmed, EBSCOhost, and EMBASE. Randomised controlled trials (RCTs) regarding vitamin D supplementation in type 2 diabetic patients with depression were retrieved through a systematic search. The outcome measured was a change in depressive symptoms evaluated with any validated rating scale. Independent data extraction was conducted, and the study quality was assessed. A meta-analysis was carried out to calculate the improvement in depressive symptoms in the group receiving vitamin D and the control group. The available evidence in RCTs was analysed using the PRISMA approach, and clinical significance was determined using the GRADE system. Risk of bias was assessed using the Cochrane Risk of Bias Tool. Results: Four RCTs were reviewed and three RCTs were meta-analysed. In two studies, vitamin D was statistically effective in improving depressive symptoms in type 2 diabetic patients. Three randomised controlled trials were included in the meta-analysis with 161 subjects using depression score as an outcome assessment. Vitamin D is significantly more effective than placebo (95% CI: -0.70 to - 0.08, p = 0.01). Conclusion: Vitamin D supplementation may improve the depressive symptoms in type 2 diabetic patients. Future research with different geographical areas and larger samples should be done to further assess the benefits.

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  • University of Indonesia
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Cleopas Martin RumendeAfiliasi tidak diketahui20
Edward FaisalAfiliasi tidak diketahui19
Ikhwan RinaldiAfiliasi tidak diketahui16
Jessica MarsigitAfiliasi tidak diketahui14
Idrus AlwiAfiliasi tidak diketahui13
Rahmi IstantiAfiliasi tidak diketahui13
Murdani AbdullahAfiliasi tidak diketahui12
Muhammad Khifzhon AzwarAfiliasi tidak diketahui12
Iris RengganisAfiliasi tidak diketahui12
Em YunirUniversity of Indonesia12
Noto DwimartutieAfiliasi tidak diketahui11
Eka GinanjarAfiliasi tidak diketahui10
Roza MulyanaAfiliasi tidak diketahui9
Alvina WidhaniAfiliasi tidak diketahui9
Pringgodigdo NugrohoAfiliasi tidak diketahui9
Dyah PurnamasariAfiliasi tidak diketahui9
Rensa RensaAfiliasi tidak diketahui8
Aulia RizkaAfiliasi tidak diketahui8
Ari Fahrial SyamAfiliasi tidak diketahui8
Cosphiadi IrawanAfiliasi tidak diketahui8
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Juferdy KurniawanAfiliasi tidak diketahui8
Dadang MakmunAfiliasi tidak diketahui7
Rudy HidayatAfiliasi tidak diketahui7
Muhammad YaminAfiliasi tidak diketahui7
Nur RiviatiAfiliasi tidak diketahui6
Esthika DewiastyAfiliasi tidak diketahui5
Aida LydiaAfiliasi tidak diketahui5
Dicky Levenus TahaparyAfiliasi tidak diketahui5
Dono AntonoAfiliasi tidak diketahui4
Cleopas M RumendeAfiliasi tidak diketahui4
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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The Effect of Vitamin D Supplementation on Symptoms of Depression in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials</dc:title>
	<dc:creator>Putranto, Rudi</dc:creator>
	<dc:creator>Harimurti, Kuntjoro</dc:creator>
	<dc:creator>Setiati, Siti</dc:creator>
	<dc:creator>Safitri, Eka Dian</dc:creator>
	<dc:creator>Saldi, Siti Rizny F</dc:creator>
	<dc:creator>Subekti, Imam</dc:creator>
	<dc:creator>Nasrun, Martina Wiwie S</dc:creator>
	<dc:creator>Shatri, Hamzah</dc:creator>
	<dc:subject xml:lang="en-US">depression</dc:subject>
	<dc:subject xml:lang="en-US">type 2 diabetes mellitus</dc:subject>
	<dc:subject xml:lang="en-US">vitamin D</dc:subject>
	<dc:subject xml:lang="en-US">psychosomatic</dc:subject>
	<dc:description xml:lang="en-US">Background: The effect of vitamin D supplementation on depressive  symptoms in people with type 2 diabetes is still up for debate. The aim of this paper was to investigate the effect of vitamin D supplementation on symptoms of depression in type 2 diabetic patients. Methods: The protocol for this review has been registered in PROSPERO:CRD42021231713. Searching for literature was conducted using Pubmed, EBSCOhost, and EMBASE. Randomised controlled trials (RCTs) regarding vitamin D supplementation in type 2 diabetic patients with depression were retrieved through a systematic search. The outcome measured was a change in depressive symptoms evaluated with any validated rating scale. Independent data extraction was conducted, and the study quality was assessed. A meta-analysis was carried out to calculate the improvement in depressive symptoms in the group receiving vitamin D and the control group. The available evidence in RCTs was analysed using the PRISMA approach, and clinical significance was determined using the GRADE system. Risk of bias was assessed using the Cochrane Risk of Bias Tool. Results: Four RCTs were reviewed and three RCTs were meta-analysed. In two studies, vitamin D was statistically effective in improving depressive symptoms in type 2 diabetic patients. Three randomised controlled trials  were included in the meta-analysis with 161 subjects using depression score as an outcome assessment. Vitamin D is significantly more effective than placebo (95% CI: -0.70 to - 0.08, p = 0.01). Conclusion: Vitamin D supplementation may improve the depressive symptoms in type 2 diabetic patients. Future research with different geographical areas and larger samples should be done to further assess the benefits.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2023-01-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">systematic review, meta analysis</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2171</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 54 No. 4 (2022): Acta Medica Indonesiana; 574</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2171/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Rudi Putranto</dc:rights>
</oai_dc:dc>