Validation of Drug Resistance in Pneumonia (DRIP) Score as Empirical Antibiotic Failure Predictor in Community-Acquired Pneumonia Patients in Cipto Mangunkusumo Hospital

Simanjuntak, Rohayat Bilmahdi; Lie, Khie Chen; Rumende, Cleopas Martin; Abdullah, Murdani; Shatri, Hamzah; Koesnoe, Soekamto; Nainggolan, Leonard; Rizka, Aulia

Jurnal SINTA 1

Validation of Drug Resistance in Pneumonia (DRIP) Score as Empirical Antibiotic Failure Predictor in Community-Acquired Pneumonia Patients in Cipto Mangunkusumo Hospital

ACTA MEDICA INDONESIANA · Vol. 56 No. 1 (2024)

ISSN: 2338-2732, 0125-9326
Terbit: 2024-04-01
Penerbit: The Indonesian Society of Internal Medicine
Bahasa: eng

Abstrak

Background: The incidence of CAP due to Drug-Resistant Pathogen (DRP) requires broad-spectrum antibiotic therapy, Drugs Resistance in Pneumonia (DRIP) score can predict these cases. The use of the DRIP score can prevent antibiotic failure and long hospitalization, but validation is needed so that the DRIP score can be used according to the local community at Cipto Mangunkusumo National Central Public Hospital. Methods: This research is a retrospective cohort study in CAP patients who were hospitalized during the period January 2019 to June 2020. Data were taken from medical records. Failure of empiric antibiotics occurs when one of these criteria is found: patient mortality, ICU transfer, and escalation of antibiotics as well as length of stay. Results: 480 patients met the criteria. There were 331 patients (69%) with a DRIP score of 0.05). AUC observations on the ROC curve obtained 0.651 (95% CI; 0.601-0.700). Conclusion: The DRIP score has low accuracy performance and calibration value in predicting empirical antibiotic failure and poor discriminatory value.

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Rudi Putranto	Afiliasi tidak diketahui	30
Ikhwan Rinaldi	Afiliasi tidak diketahui	21
Robert Sinto	Afiliasi tidak diketahui	20
Siti Setiati	Afiliasi tidak diketahui	16
Erni Juwita Nelwan	Afiliasi tidak diketahui	12
Edward Faisal	Afiliasi tidak diketahui	11
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Adeline Pasaribu	Afiliasi tidak diketahui	10
Dadang Makmun	Afiliasi tidak diketahui	8
Iris Rengganis	Afiliasi tidak diketahui	7
Imam Subekti	Afiliasi tidak diketahui	7
Em Yunir	University of Indonesia	7
Ari Fahrial Syam	Afiliasi tidak diketahui	7
Sally Aman Nasution	Afiliasi tidak diketahui	7
Kuntjoro Harimurti	Afiliasi tidak diketahui	7
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Marcellus Simadibrata	Afiliasi tidak diketahui	5
Kaka Renaldi	Afiliasi tidak diketahui	5
Irsan Hasan	Afiliasi tidak diketahui	5
Mira Yulianti	Afiliasi tidak diketahui	4
Idrus Alwi	Afiliasi tidak diketahui	4
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Esthika Dewiasty	Afiliasi tidak diketahui	4
Dina Elita	Afiliasi tidak diketahui	3
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Metadata asli (oai_dc)

<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Validation of Drug Resistance in Pneumonia (DRIP) Score as Empirical Antibiotic Failure Predictor in Community-Acquired Pneumonia Patients in Cipto Mangunkusumo Hospital</dc:title>
	<dc:creator>Simanjuntak, Rohayat Bilmahdi</dc:creator>
	<dc:creator>Lie, Khie Chen</dc:creator>
	<dc:creator>Rumende, Cleopas Martin</dc:creator>
	<dc:creator>Abdullah, Murdani</dc:creator>
	<dc:creator>Shatri, Hamzah</dc:creator>
	<dc:creator>Koesnoe, Soekamto</dc:creator>
	<dc:creator>Nainggolan, Leonard</dc:creator>
	<dc:creator>Rizka, Aulia</dc:creator>
	<dc:subject xml:lang="en-US">DRIP score</dc:subject>
	<dc:subject xml:lang="en-US">antibiotics failure</dc:subject>
	<dc:subject xml:lang="en-US">Drug-Resistant Pathogens</dc:subject>
	<dc:subject xml:lang="en-US">Community-Acquired Pneumonia</dc:subject>
	<dc:description xml:lang="en-US">Background: The incidence of CAP due to Drug-Resistant Pathogen (DRP) requires broad-spectrum antibiotic therapy, Drugs Resistance in Pneumonia (DRIP) score can predict these cases. The use of the DRIP score can prevent antibiotic failure and long hospitalization, but validation is needed so that the DRIP score can be used according to the local community at Cipto Mangunkusumo National Central Public Hospital. Methods: This research is a retrospective cohort study in CAP patients who were hospitalized during the period January 2019 to June 2020. Data were taken from medical records. Failure of empiric antibiotics occurs when one of these criteria is found: patient mortality, ICU transfer, and escalation of antibiotics as well as length of stay. Results: 480 patients met the criteria. There were 331 patients (69%) with a DRIP score of &amp;lt;4 and 149 patients (31%) with a DRIP score of≥4. A total of 283 patients (59%) of antibiotic failures were detailed in 174 patients with a DRIP score &amp;lt;4 and 109 patients DRIP score ≥4. DRIP calibration using the Hosmer-Lemeshow test obtained p-value= 0.667 (p&amp;gt;0.05). AUC observations on the ROC curve obtained 0.651 (95% CI; 0.601-0.700). Conclusion: The DRIP score has low accuracy performance and calibration value in predicting empirical antibiotic failure and poor discriminatory value.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2024-04-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2342</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 56 No. 1 (2024): Acta Medica Indonesiana; 55</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2342/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 Rohayat Bilmahdi Simanjuntak</dc:rights>
</oai_dc:dc>