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Gender Differences of Gly972Arg Polymorphism of the IRS-1 Gene Related to Cardiovascular Disease Risk Factors Among Indonesians

ACTA MEDICA INDONESIANA · Vol. 55 No. 3 (2023)

ISSN
2338-2732, 0125-9326
Terbit
2023-11-01
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: Cardiovascular disease is driven by traditional risk factors, sex, and genetic differences. The Asian population, specifically Indonesians, has been known at high risk of insulin resistance and endothelial dysfunction. A possible genetic risk factor related to cardiovascular diseases is Gly972Arg polymorphism of insulin receptor substrate 1 (IRS-1) gene, as this impairs endothelial function. To date, whether there is a gender difference in Gly972Arg polymorphism of the IRS-1 gene in Indonesians is unknown. This study aimed to to define whether there is a gender difference in Gly972Arg polymorphism of the IRS-1 gene in Indonesians. Methods: We studied adults living in two areas (rural and urban) in Indonesia. We collected demographic and clinical data from the study subjects. Gly972Arg polymorphism of the IRS-1 gene (rs1801278) was detected using TaqMan real-time polymerase chain reaction. Results: A total of 378 subjects were recruited. The wild-type allele (CC) was found in 86 (22.8%) subjects, heterozygous mutant allele (CT) in 245 (64.8%), and homozygous mutant allele in 47 (12.4%). The proportion of subjects with T alleles was significantly higher among women than men (54.6% vs. 45.4%, odds ratio: 1.89; p = 0.01). Subjects with T allele more often have hypertension (odds ratio: 1.69, p = 0.058). Conclusion: There were a higher proportion of women than men carrying the T allele of Gly972Arg polymorphism among Indonesians. Individuals with the T allele appeared to show a greater prevalence of hypertension. These results may explain a possible mechanism of the high prevalence of metabolic syndrome in Indonesia, especially in women.

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Dony Yugo HermantoAfiliasi tidak diketahui2
Indira Aura BalqisAfiliasi tidak diketahui2
Dicky Armein HanafyAfiliasi tidak diketahui2
Vienna RossimarinaAfiliasi tidak diketahui2
Wisnu JatmikoUniversity of Indonesia1
Grafika JatiUniversity of Indonesia1
Mgs M Luthfi RamadhanUniversity of Indonesia1
Idrus AlwiAfiliasi tidak diketahui1
Aria KekalihAfiliasi tidak diketahui1
Budi WiwekoAfiliasi tidak diketahui1
Lies Dina LiastutiAfiliasi tidak diketahui1
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Yosilia NursakinaAfiliasi tidak diketahui1
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Ericko GovardiAfiliasi tidak diketahui1
Aqsha Azhary NurAfiliasi tidak diketahui1
Eka Adip PradiptaAfiliasi tidak diketahui1
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Widya SafitriAfiliasi tidak diketahui1
Suci IndrianiAfiliasi tidak diketahui1
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Daniel Paringotan L. TobingAfiliasi tidak diketahui1
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Gadistya Novitri AdindaAfiliasi tidak diketahui1
Yoga YuniadiAfiliasi tidak diketahui1
Ira PosangiAfiliasi tidak diketahui1
Ridwan Rasyid WaliyuddinAfiliasi tidak diketahui1
Chin-Yu LinAfiliasi tidak diketahui1
Yuda TuranaAfiliasi tidak diketahui1
Noriko MatsushitaAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Gender Differences of Gly972Arg Polymorphism of the IRS-1 Gene Related to Cardiovascular Disease Risk Factors Among Indonesians</dc:title>
	<dc:creator>Sukmawan, Renan</dc:creator>
	<dc:creator>Akip, Harry Mahathir</dc:creator>
	<dc:creator>Wulandari, Priyandini</dc:creator>
	<dc:creator>Bobians, Evans T</dc:creator>
	<dc:creator>Koencoro, BRM Ario Soeryo</dc:creator>
	<dc:creator>Danny, Siska Suridanda</dc:creator>
	<dc:creator>Ambari, Ade Meidian</dc:creator>
	<dc:creator>Raharjo, Sunu Budhi</dc:creator>
	<dc:creator>Widyantoro, Bambang</dc:creator>
	<dc:creator>Adiarto, Suko</dc:creator>
	<dc:subject xml:lang="en-US">Gender</dc:subject>
	<dc:subject xml:lang="en-US">Gly972Arg polymorphism</dc:subject>
	<dc:subject xml:lang="en-US">IRS-1 gene</dc:subject>
	<dc:subject xml:lang="en-US">Indonesian</dc:subject>
	<dc:description xml:lang="en-US">Background: Cardiovascular disease is driven by traditional risk factors, sex, and genetic differences. The Asian population, specifically Indonesians, has been known at high risk of insulin resistance and endothelial dysfunction. A possible genetic risk factor related to cardiovascular diseases is Gly972Arg polymorphism of insulin receptor substrate 1 (IRS-1) gene, as this impairs endothelial function. To date, whether there is a gender difference in Gly972Arg polymorphism of the IRS-1 gene in Indonesians is unknown. This study aimed to to define whether there is a gender difference in Gly972Arg polymorphism of the IRS-1 gene in Indonesians. Methods: We studied adults living in two areas (rural and urban) in Indonesia. We collected demographic and clinical data from the study subjects. Gly972Arg polymorphism of the IRS-1 gene (rs1801278) was detected using TaqMan real-time polymerase chain reaction. Results: A total of 378 subjects were recruited. The wild-type allele (CC) was found in 86 (22.8%) subjects, heterozygous mutant allele (CT) in 245 (64.8%), and homozygous mutant allele in 47 (12.4%). The proportion of subjects with T alleles was significantly higher among women than men (54.6% vs. 45.4%, odds ratio: 1.89; p = 0.01). Subjects with T allele more often have hypertension (odds ratio: 1.69, p = 0.058). Conclusion: There were a higher proportion of women than men carrying the T allele of Gly972Arg polymorphism among Indonesians. Individuals with the T allele appeared to show a greater prevalence of hypertension. These results may explain a possible mechanism of the high prevalence of metabolic syndrome in Indonesia, especially in women.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2023-11-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2416</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 55 No. 3 (2023): Acta Medica Indonesiana; 255</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2416/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Renan Sukmawan, Harry Mahathir Akip, Priyandini Wulandari, BRM Ario Soeryo Koencoro, Siska Suridanda Danny, Ade Meidian Ambari, Sunu Budhi Raharjo, Bambang Widyantoro, Suko Adiarto</dc:rights>
</oai_dc:dc>