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Genetic Polymorphisms Associated with Cyclophosphamide Outcome and Risk of Toxicity in Patients with Lupus Nephritis

ACTA MEDICA INDONESIANA · Vol. 55 No. 3 (2023)

ISSN
2338-2732, 0125-9326
Terbit
2023-11-01
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

A 6-month cyclophosphamide induction therapy followed by maintenance therapy every three months is the first-line treatment for Class III, IV, and V lupus nephritis. Among the 139 single nucleotide polymorphisms (SNPs) associated with cyclophosphamide, four SNPs, namely rs4244285, rs4802101, rs7254579 and rs3957356, are related to the response and risk of toxicity in patients with lupus nephritis. Although pharmacogenetic studies in patients with lupus nephritis (LN) have not been conducted previously in Indonesia, data on rs4244285 are available for several ethnic groups, including Papuans, Bataks, Balinese, Dayaks, Javanese, Bugis, Chinese, Timorese and Malays, even though direct evidence in LN patients is less detectable. However, this can be followed up prior to cyclophosphamide therapy based on the identification of genetic markers. Therefore, clinical studies in patients with lupus nephritis are deemed necessary to evaluate the potential of these markers.

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  • University of Darussalam Gontor
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Indra WijayaAfiliasi tidak diketahui3
Amaylia OehadianAfiliasi tidak diketahui2
Irsan HasanAfiliasi tidak diketahui1
Trinugroho Heri FadjariAfiliasi tidak diketahui1
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Sasfia CandrianitaAfiliasi tidak diketahui1
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Ria BandiaraAfiliasi tidak diketahui1
Lisda AmaliaAfiliasi tidak diketahui1
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Andri Reza RahmadiAfiliasi tidak diketahui1
Fransisca FransiscaAfiliasi tidak diketahui1
Mohammad GhozaliUniversity of Darussalam Gontor1
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Lusi MersianaAfiliasi tidak diketahui1
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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Genetic Polymorphisms Associated with Cyclophosphamide Outcome and Risk of Toxicity in Patients with Lupus Nephritis</dc:title>
	<dc:creator>Indrawijaya, Yen Yen Ari</dc:creator>
	<dc:creator>Hamijoyo, Laniyati</dc:creator>
	<dc:creator>Artarini, Aluicia Anita</dc:creator>
	<dc:creator>Iwo, Maria Immaculata</dc:creator>
	<dc:subject xml:lang="en-US">Cyclophosphamide</dc:subject>
	<dc:subject xml:lang="en-US">SNP</dc:subject>
	<dc:subject xml:lang="en-US">response</dc:subject>
	<dc:subject xml:lang="en-US">risk of toxicity</dc:subject>
	<dc:subject xml:lang="en-US">renal</dc:subject>
	<dc:description xml:lang="en-US">A 6-month cyclophosphamide induction therapy followed by maintenance therapy every three months is the first-line treatment for Class III, IV, and V lupus nephritis. Among the 139 single nucleotide polymorphisms (SNPs) associated with cyclophosphamide, four SNPs, namely rs4244285, rs4802101, rs7254579 and rs3957356, are related to the response and risk of toxicity in patients with lupus nephritis. Although pharmacogenetic studies in patients with lupus nephritis (LN) have not been conducted previously in Indonesia, data on rs4244285 are available for several ethnic groups, including Papuans, Bataks, Balinese, Dayaks, Javanese, Bugis, Chinese, Timorese and Malays, even though direct evidence in LN patients is less detectable. However, this can be followed up prior to cyclophosphamide therapy based on the identification of genetic markers. Therefore, clinical studies in patients with lupus nephritis are deemed necessary to evaluate the potential of these markers.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2023-11-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Review Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2432</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 55 No. 3 (2023): Acta Medica Indonesiana; 343</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2432/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Yen Yen Ari Indrawijaya, Laniyati Hamijoyo, Aluicia Anita Artarini, Maria Immaculata Iwo</dc:rights>
</oai_dc:dc>