Melola Discovery

← Melola Discovery

Jurnal SINTA 1

CXCL8, MMP1, MMP2, and FN1 Gene Expression and Tumor Extension in Nasopharyngeal Cancer Patients: A Cross-sectional Study

ACTA MEDICA INDONESIANA · Vol. 55 No. 3 (2023)

ISSN
2338-2732, 0125-9326
Terbit
2023-11-01
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: There are correlations between tumor staging, lymph node involvement, and patient survival in Nasopharyngeal cancer (NPC) which is one of the most common types of cancer in Indonesia. The inflammation process plays a role in tumor progression over the long term and this marked by increased proinflammatory cytokine and gene overexpression. This study aims to identify differentially expressed genes (DEGs) in NPC using T and N staging. Methods: This is a cross-sectional study of NPC patients in Cipto Mangunkusumo, Jakarta, between 2018 and 2022. DEGs were identified based on the amount of mRNA detected on paraffin blocks with a 1.5- to -1.5-fold change and an adjusted p-value of <0.05. Results: We included 48 subjects. The mean age of subjects was 47.75 (10.48) years, and most were male (77.1%). Non-keratinized squamous cell carcinoma was the most common histopathology type. Differences in the tumor size of the T4 and non-T4 in metastatic (33.3%) group when compared to the non-metastatic (37.5%) group were insignificant (p = 0.763). The proportion of N3 subjects in the metastatic vs non-metastatic group was different significantly (83.3% vs. 50%, p = 0.030). Gene expression analysis showed that C-X-C motif ligand 8 (CXCL8), matrix metalloproteinase-1 (MMP1), matrix metalloproteinase-1 (MMP2), and fibronectin-1 (FN1) genes of the T4 and non-T4 group to be different significantly. Conclusion: There was significant finding in the N3 subjects of the metastatic and non-metastatic groups. The DEGs of CXCL8, MMP1, MMP2, and FN1 were statistically significant in the T4 when compared to the non-T4 group.

Kata kunci

Jaringan kolaborasi para penulis

40 penulis · 148 tautan kepenulisan bersama · menampilkan 40 yang paling banyak terhubung

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • University of Indonesia
  • Universitas Halu Oleo
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Em YunirUniversity of Indonesia4
Hamzah ShatriAfiliasi tidak diketahui3
Rudi PutrantoAfiliasi tidak diketahui3
Djumhana AtmakusumahAfiliasi tidak diketahui3
Abdulmuthalib AbdulmuthalibAfiliasi tidak diketahui3
Tri Juli Edi TariganUniversity of Indonesia3
Imam SubektiAfiliasi tidak diketahui3
Aru W SudoyoAfiliasi tidak diketahui2
Idrus AlwiAfiliasi tidak diketahui2
Mizanul AdliAfiliasi tidak diketahui2
Dina ElitaAfiliasi tidak diketahui2
Ratih Arianita AgungAfiliasi tidak diketahui2
Czeresna Heriawan SoejonoAfiliasi tidak diketahui2
Andhika RachmanAfiliasi tidak diketahui2
Aulia RizkaAfiliasi tidak diketahui2
La Ode Muhammad Harjoni KilowasidAfiliasi tidak diketahui1
Nurhaida NurhaidaAfiliasi tidak diketahui1
Samsu AlamAfiliasi tidak diketahui1
Sarawa SarawaAfiliasi tidak diketahui1
Dodi Priyatmo SilondaeUniversitas Halu Oleo1
Sudarmi Suud BinasarAfiliasi tidak diketahui1
SupriyonoAfiliasi tidak diketahui1
Dadi Mulyadi NugrahaAfiliasi tidak diketahui1
Judhiastuty FebruhartantyAfiliasi tidak diketahui1
Fitya Safira BirahmatikaAfiliasi tidak diketahui1
Khalida FauziaAfiliasi tidak diketahui1
Indriya Laras PramesthiAfiliasi tidak diketahui1
Helda KhusunAfiliasi tidak diketahui1
Hera NurlitaAfiliasi tidak diketahui1
Ahmad Thohir HidayatAfiliasi tidak diketahui1
Teguh BudiharjoAfiliasi tidak diketahui1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">CXCL8, MMP1, MMP2, and FN1 Gene Expression and Tumor Extension in Nasopharyngeal Cancer Patients:  A Cross-sectional Study</dc:title>
	<dc:creator>Cahyanur, Rahmat</dc:creator>
	<dc:creator>Irawan, Cosphiadi</dc:creator>
	<dc:creator>Lisnawati, Lisnawati</dc:creator>
	<dc:creator>Adham, Marlinda</dc:creator>
	<dc:creator>Kamal, Achmad Fauzi</dc:creator>
	<dc:creator>Utomo, Ahmad R. Handoyo</dc:creator>
	<dc:creator>Hardianti, Mardiah Suci</dc:creator>
	<dc:creator>Mansyur, Muchtaruddin</dc:creator>
	<dc:creator>Salamah, Thariqah</dc:creator>
	<dc:subject xml:lang="en-US">nasopharyngeal cancer</dc:subject>
	<dc:subject xml:lang="en-US">C-X-C Ligand 8</dc:subject>
	<dc:subject xml:lang="en-US">matrix metalloproteinase-1</dc:subject>
	<dc:subject xml:lang="en-US">matrix metalloproteinase-2</dc:subject>
	<dc:subject xml:lang="en-US">fibronectin-1</dc:subject>
	<dc:description xml:lang="en-US">Background: There are correlations between tumor staging, lymph node involvement, and patient survival in Nasopharyngeal cancer (NPC) which is one of the most common types of cancer in Indonesia.  The inflammation process plays a role in tumor progression over the long term and this marked by increased proinflammatory cytokine and gene overexpression. This study aims to identify differentially expressed genes (DEGs) in NPC using T and N staging. Methods: This is a cross-sectional study of NPC patients in Cipto Mangunkusumo, Jakarta, between 2018 and 2022. DEGs were identified based on the amount of mRNA detected on paraffin blocks with a 1.5- to -1.5-fold change and an adjusted p-value of &amp;lt;0.05. Results: We included 48 subjects. The mean age of subjects was 47.75 (10.48) years, and most were male (77.1%). Non-keratinized squamous cell carcinoma was the most common histopathology type. Differences in the tumor size of the T4 and non-T4 in metastatic (33.3%) group when compared to the non-metastatic (37.5%) group were insignificant (p = 0.763). The proportion of N3 subjects in the metastatic vs non-metastatic group was different significantly (83.3% vs. 50%, p = 0.030). Gene expression analysis showed that C-X-C motif ligand 8 (CXCL8), matrix metalloproteinase-1 (MMP1), matrix metalloproteinase-1 (MMP2), and fibronectin-1 (FN1) genes of the T4 and non-T4 group to be different significantly. Conclusion: There was significant finding in the N3 subjects of the metastatic and non-metastatic groups. The DEGs of CXCL8, MMP1, MMP2, and FN1 were statistically significant in the T4 when compared to the non-T4 group.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2023-11-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">cross sectional</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2442</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 55 No. 3 (2023): Acta Medica Indonesiana; 261</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2442/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Rahmat Cahyanur</dc:rights>
</oai_dc:dc>