A Rare Case of Pulmonary Neuroendocrine Carcinoma in Transfusion-dependent Thalassemia Patient: Clinical Presentation, Management, and Implications

Sasmithae, Lia; Oehadian, Amaylia; Prasetya, Dimmy

Jurnal SINTA 1

A Rare Case of Pulmonary Neuroendocrine Carcinoma in Transfusion-dependent Thalassemia Patient: Clinical Presentation, Management, and Implications

ACTA MEDICA INDONESIANA · Vol. 56 No. 3 (2024)

ISSN: 2338-2732, 0125-9326
Terbit: 2024-10-25
Penerbit: The Indonesian Society of Internal Medicine
Bahasa: eng

Abstrak

Transfusion-dependent thalassemia (TDT) is often accompanied by complications related to iron overload and the development of malignant solid tumors or hematological malignancies. The occurrence of Neuroendocrine carcinoma, specifically in the respiratory tract, is very rare, with a prevalence of approximately 25%. Therefore, this study presented a case of a 42-year-old male with a beta-thalassemia major at 28 years, complaining of shortness of breath. This case was reported due to its rarity in providing information about solid tumors in thalassemia patients. The physical examination revealed several symptoms, including tachycardia, tachypnea, anemia, icteric sclera, elevated jugular venous pressure, coarse wet Ronchi in the medial to basal areas of both lungs, hepatomegaly, and splenomegaly (Schuffner 4). The patient regularly received blood transfusions and iron chelation therapy. A thoracic CT scan showed a lung mass and a biopsy of the mass revealed Pulmonary Neuroendocrine Carcinoma with high-grade proliferation and, large cell type. The patient also passed through cisplatin-etoposide chemotherapy for 6 cycles every 21 days. There is almost no data on pulmonary neuroendocrine carcinoma in thalassemia patients, so it is hoped that this case report can provide information about malignant solid tumors that can occur in thalassemia patients.

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University of Darussalam Gontor
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Rekan penulis	Organisasi	Artikel bersama
Laniyati Hamijoyo	Afiliasi tidak diketahui	3
Een Hendarsih	Afiliasi tidak diketahui	1
Trinugroho H Fadjari	Afiliasi tidak diketahui	1
Guntur Darmawan	Afiliasi tidak diketahui	1
Ria Bandiara	Afiliasi tidak diketahui	1
Lisda Amalia	Afiliasi tidak diketahui	1
Indra Wijaya	Afiliasi tidak diketahui	1
Bachti Alisjahbana	Afiliasi tidak diketahui	1
M Lucky Nurdiansyah Prameswara	Afiliasi tidak diketahui	1
Andri Reza Rahmadi	Afiliasi tidak diketahui	1
Fransisca Fransisca	Afiliasi tidak diketahui	1
Mohammad Ghozali	University of Darussalam Gontor	1
Sutiadi Kusuma	Afiliasi tidak diketahui	1
Lusi Mersiana	Afiliasi tidak diketahui	1
Nadia Gita Ghassani	Afiliasi tidak diketahui	1
Yitzchak Millenard Sigilipu	Afiliasi tidak diketahui	1
Andini Kartikasari	Afiliasi tidak diketahui	1

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.

Metadata asli (oai_dc)

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	<dc:title xml:lang="en-US">A Rare Case of Pulmonary Neuroendocrine Carcinoma  in Transfusion-dependent Thalassemia Patient:  Clinical Presentation, Management, and Implications</dc:title>
	<dc:creator>Sasmithae, Lia</dc:creator>
	<dc:creator>Oehadian, Amaylia</dc:creator>
	<dc:creator>Prasetya, Dimmy</dc:creator>
	<dc:subject xml:lang="en-US">Thalassaemia</dc:subject>
	<dc:subject xml:lang="en-US">Neuroendocrine Carsinoma</dc:subject>
	<dc:subject xml:lang="en-US">Malignant solid tumor</dc:subject>
	<dc:subject xml:lang="en-US">hematology</dc:subject>
	<dc:subject xml:lang="en-US">oncology</dc:subject>
	<dc:description xml:lang="en-US">Transfusion-dependent thalassemia (TDT) is often accompanied by complications related to iron overload and the development of malignant solid tumors or hematological malignancies. The occurrence of Neuroendocrine carcinoma, specifically in the respiratory tract, is very rare, with a prevalence of approximately 25%. Therefore, this study presented a case of a 42-year-old male with a beta-thalassemia major at 28 years, complaining of shortness of breath. This case was reported due to its rarity in providing information about solid tumors in thalassemia patients. The physical examination revealed several symptoms, including tachycardia, tachypnea, anemia, icteric sclera, elevated jugular venous pressure, coarse wet Ronchi in the medial to basal areas of both lungs, hepatomegaly, and splenomegaly (Schuffner 4). The patient regularly received blood transfusions and iron chelation therapy. A thoracic CT scan showed a lung mass and a biopsy of the mass revealed Pulmonary Neuroendocrine Carcinoma with high-grade proliferation and, large cell type. The patient also passed through cisplatin-etoposide chemotherapy for 6 cycles every 21 days. There is almost no data on pulmonary neuroendocrine carcinoma in thalassemia patients, so it is hoped that this case report can provide information about malignant solid tumors that can occur in thalassemia patients.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2024-10-25</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">-</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2478</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 56 No. 3 (2024): Acta Medica Indonesiana; 370</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2478/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 amaylia oehadian</dc:rights>
</oai_dc:dc>