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Effectiveness and Safety of Nebulized Magnesium as Last Line Treatment in Adults with Acute Asthma Attack: A Systematic Review and Meta-Analysis

ACTA MEDICA INDONESIANA · Vol. 56 No. 1 (2024)

ISSN
2338-2732, 0125-9326
Terbit
2024-04-01
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: Asthma is a disease characterized by chronic airway inflammation, however one-third of asthmatic cases did not respond adequately. Inhaled magnesium has been proposed as a treatment for unresponsive asthma cases. However, its role remains controversial. This review evaluates the effectiveness and safety of nebulized magnesium compared to standard therapy (Beta Agonist, Anticholinergic, Corticosteroid) in adults with acute asthma attacks. Methods: The protocol has been registered in PROSPERO. A literature search was conducted through PubMed/MEDLINE, Cochrane, ProQuest, and Google Scholar, and using the keywords “inhaled magnesium” and “asthma”. Manual searches were carried out through data portals. Journal articles included are randomized controlled trials. The assessment risk of bias was performed using Version 2 of the Cochrane risk-of-bias tool for randomized trials. Results: There are five articles included in this review. There is no significant difference in readmission rate and oxygen saturation in the magnesium group compared to control (RR 1; 95% CI 0.92 to 1,08; p= 0,96 and MD 1,82; 95% CI -0.89 to 4.53; p= 0.19, respectively). There is a significant reduction of respiratory rate and clinical severity in magnesium (MD -1,72; 95% CI -3,1 to 0.35; p= 0.01, RR 0.29; 95% CI 0.17 to 0.69; p <0.001, respectively). There was a higher risk of side effects in the magnesium group (HR 1.56; 95%CI 1.05 to 2.32; p= 0.03). However, the side effects are relatively mild such as hypotension and nausea. Conclusion: Inhaled magnesium improves the outcome of asthmatic patients, especially in lung function, clinical severity, and respiratory rate. Moreover, inhaled magnesium is safe to be given.

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Rekan penulisOrganisasiArtikel bersama
Edward FaisalAfiliasi tidak diketahui19
Ikhwan RinaldiAfiliasi tidak diketahui19
Siti SetiatiAfiliasi tidak diketahui18
Alvina WidhaniAfiliasi tidak diketahui14
Murdani AbdullahAfiliasi tidak diketahui13
Kuntjoro HarimurtiAfiliasi tidak diketahui12
Em YunirUniversity of Indonesia10
Eka GinanjarAfiliasi tidak diketahui10
Imam SubektiAfiliasi tidak diketahui9
Pringgodigdo NugrohoAfiliasi tidak diketahui7
Idrus AlwiAfiliasi tidak diketahui7
Khie Chen LieAfiliasi tidak diketahui7
Evy YunihastutiAfiliasi tidak diketahui7
Dadang MakmunAfiliasi tidak diketahui6
Cosphiadi IrawanAfiliasi tidak diketahui6
Dina ElitaAfiliasi tidak diketahui6
Juferdy KurniawanAfiliasi tidak diketahui6
Leonard NainggolanAfiliasi tidak diketahui6
Muhadi MuhadiAfiliasi tidak diketahui5
Anshari Saifuddin HasibuanAfiliasi tidak diketahui5
Sukamto KoesnoeAfiliasi tidak diketahui5
Rudy HidayatAfiliasi tidak diketahui5
Andhika RachmanAfiliasi tidak diketahui5
Robert SintoAfiliasi tidak diketahui5
Irsan HasanAfiliasi tidak diketahui5
Mira YuliantiAfiliasi tidak diketahui4
Suzy MariaAfiliasi tidak diketahui4
Adityo SusiloAfiliasi tidak diketahui4
Agus Joko SusantoAfiliasi tidak diketahui3
Dono AntonoAfiliasi tidak diketahui3
Cleopas M RumendeAfiliasi tidak diketahui3
Ika Prasetya WijayaAfiliasi tidak diketahui3

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Effectiveness and Safety of Nebulized Magnesium  as Last Line Treatment in Adults with Acute Asthma Attack: A Systematic Review and Meta-Analysis</dc:title>
	<dc:creator>Darmawan, Danny</dc:creator>
	<dc:creator>Rengganis, Iris</dc:creator>
	<dc:creator>Rumende, Cleopas Martin</dc:creator>
	<dc:creator>Shatri, Hamzah</dc:creator>
	<dc:creator>Koesnoe, Soekamto</dc:creator>
	<dc:creator>Umbarawan, Yogi</dc:creator>
	<dc:creator>Putranto, Rudi</dc:creator>
	<dc:creator>Nasution, Sally Aman</dc:creator>
	<dc:subject xml:lang="en-US">Inhaled Magnesium</dc:subject>
	<dc:subject xml:lang="en-US">Asthma</dc:subject>
	<dc:subject xml:lang="en-US">Adult</dc:subject>
	<dc:subject xml:lang="en-US">asthma</dc:subject>
	<dc:description xml:lang="en-US">Background: Asthma is a disease characterized by chronic airway inflammation, however one-third of asthmatic cases did not respond adequately. Inhaled magnesium has been proposed as a treatment for unresponsive asthma cases. However, its role remains controversial. This review evaluates the effectiveness and safety of nebulized magnesium compared to standard therapy (Beta Agonist, Anticholinergic, Corticosteroid) in adults with acute asthma attacks. Methods: The protocol has been registered in PROSPERO. A literature search was conducted through PubMed/MEDLINE, Cochrane, ProQuest, and Google Scholar, and using the keywords “inhaled magnesium” and “asthma”. Manual searches were carried out through data portals. Journal articles included are randomized controlled trials. The assessment risk of bias was performed using Version 2 of the Cochrane risk-of-bias tool for randomized trials. Results: There are five articles included in this review. There is no significant difference in readmission rate and oxygen saturation in the magnesium group compared to control (RR 1; 95% CI 0.92 to 1,08; p= 0,96 and MD 1,82; 95% CI -0.89 to 4.53; p= 0.19, respectively). There is a significant reduction of respiratory rate and clinical severity in magnesium (MD -1,72; 95% CI -3,1 to 0.35; p= 0.01, RR 0.29; 95% CI 0.17 to 0.69; p &amp;lt;0.001, respectively). There was a higher risk of side effects in the magnesium group (HR 1.56; 95%CI 1.05 to 2.32; p= 0.03). However, the side effects are relatively mild such as hypotension and nausea. Conclusion: Inhaled magnesium improves the outcome of asthmatic patients, especially in lung function, clinical severity, and respiratory rate. Moreover, inhaled magnesium is safe to be given.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2024-04-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2563</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 56 No. 1 (2024): Acta Medica Indonesiana; 3</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2563/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 Danny Darmawan</dc:rights>
</oai_dc:dc>