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Peripheral Classic and Intermediate Monocyte Subsets as Immune Biomarkers of Systemic Lupus Erythematosus Disease Activity

ACTA MEDICA INDONESIANA · Vol. 56 No. 4 (2025)

ISSN
2338-2732, 0125-9326
Terbit
2025-01-21
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: Monocytes are evolutionarily preserved innate immune cells that play essential roles in immune response regulation. Three activated monocyte subsets—classical (CD14++CD16–), intermediate (CD14++CD16+), and nonclassical (CD14+CD16++)—are associated with systemic lupus erythematosus (SLE) progression. This study aims to determine the association of monocyte subsets with SLE disease activity. Methods: A cross-sectional study involving 25 patients with SLE was conducted. Blood samples were collected, and monocyte subsets were identified using flow cytometry. Patients were grouped by disease activity using the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) into inactive (SLEDAI-2K ≤ 4) and active (SLEDAI-2K > 4). The cutoff for monocyte subsets was determined using Receiver Operating Characteristic (ROC) analysis. Results: Nine active and 16 inactive subjects were identified. Compared with individuals without active disease, individuals with active disease had significantly lower mean classical monocyte subsets (71.9% vs 88%, p = 0.008), and higher median intermediate monocytes (29.1% vs 11.1%, p = 0.019). The median nonclassical monocyte subsets were not significantly different between the two groups. The cutoff for classical monocytes in active disease was ≤72.2%, AUC = 0.788, p = 0.021, with 66.7% sensitivity and 87.5% specificity; for intermediate monocytes, it was >22.3%, AUC = 0.788, p = 0.014, with 66.7% sensitivity and 100% specificity. Conclusion: Classical and intermediate monocytes could be considered as immune cellular markers for identifying active SLE.

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  • University of Darussalam Gontor
  • Universitas Islam Negeri Ar-Raniry
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Rekan penulisOrganisasiArtikel bersama
Guntur DarmawanAfiliasi tidak diketahui6
Indra WijayaAfiliasi tidak diketahui3
Ria BandiaraAfiliasi tidak diketahui2
Lisda AmaliaAfiliasi tidak diketahui2
Dimmy PrasetyaAfiliasi tidak diketahui2
Hasanuddin Yusuf AdanUniversitas Islam Negeri Ar-Raniry1
Devid Frastiawan Amir SupUniversity of Darussalam Gontor1
Ika PrastyaningsihUniversity of Darussalam Gontor1
Een HendarsihAfiliasi tidak diketahui1
Trinugroho H FadjariAfiliasi tidak diketahui1
Irsan HasanAfiliasi tidak diketahui1
Trinugroho Heri FadjariAfiliasi tidak diketahui1
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Januar Wibawa MarthaAfiliasi tidak diketahui1
Syarief HidayatAfiliasi tidak diketahui1
Mohammad Rizki AkbarAfiliasi tidak diketahui1
Henny TantonoAfiliasi tidak diketahui1
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Aang SetiawanAfiliasi tidak diketahui1
Yen Yen Ari IndrawijayaAfiliasi tidak diketahui1
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Maria Immaculata IwoAfiliasi tidak diketahui1
Bethy S HernowoAfiliasi tidak diketahui1
Dinar F YaddinAfiliasi tidak diketahui1
Panji Irani FianzaAfiliasi tidak diketahui1
Hermin Aminah UsmanAfiliasi tidak diketahui1
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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Peripheral Classic and Intermediate Monocyte Subsets as Immune Biomarkers of Systemic Lupus Erythematosus Disease Activity</dc:title>
	<dc:creator>Oehadian, Amaylia</dc:creator>
	<dc:creator>Ghozali, Mohammad</dc:creator>
	<dc:creator>Kusuma, Sutiadi</dc:creator>
	<dc:creator>Mersiana, Lusi</dc:creator>
	<dc:creator>Ghassani, Nadia Gita</dc:creator>
	<dc:creator>Fransisca, Fransisca</dc:creator>
	<dc:creator>Sigilipu, Yitzchak Millenard</dc:creator>
	<dc:creator>Kartikasari, Andini</dc:creator>
	<dc:creator>Hamijoyo, Laniyati</dc:creator>
	<dc:subject xml:lang="en-US">Monocytes Subset</dc:subject>
	<dc:subject xml:lang="en-US">SLE</dc:subject>
	<dc:subject xml:lang="en-US">Classical Monocytes</dc:subject>
	<dc:subject xml:lang="en-US">Intermediate Monocytes</dc:subject>
	<dc:subject xml:lang="en-US">Disease Activity</dc:subject>
	<dc:description xml:lang="en-US">Background: Monocytes are evolutionarily preserved innate immune cells that play essential roles in immune response regulation. Three activated monocyte subsets—classical (CD14++CD16–), intermediate (CD14++CD16+), and nonclassical (CD14+CD16++)—are associated with systemic lupus erythematosus (SLE) progression. This study aims to determine the association of monocyte subsets with SLE disease activity. Methods: A cross-sectional study involving 25 patients with SLE was conducted. Blood samples were collected, and monocyte subsets were identified using flow cytometry. Patients were grouped by disease activity using the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) into inactive (SLEDAI-2K ≤ 4) and active (SLEDAI-2K &amp;gt; 4). The cutoff for monocyte subsets was determined using Receiver Operating Characteristic (ROC) analysis. Results: Nine active and 16 inactive subjects were identified. Compared with individuals without active disease, individuals with active disease had significantly lower mean classical monocyte subsets (71.9% vs 88%, p = 0.008), and higher median intermediate monocytes (29.1% vs 11.1%, p = 0.019). The median nonclassical monocyte subsets were not significantly different between the two groups. The cutoff for classical monocytes in active disease was ≤72.2%, AUC = 0.788, p = 0.021, with 66.7% sensitivity and 87.5% specificity; for intermediate monocytes, it was &amp;gt;22.3%, AUC = 0.788, p = 0.014, with 66.7% sensitivity and 100% specificity. Conclusion: Classical and intermediate monocytes could be considered as immune cellular markers for identifying active SLE.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2025-01-21</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2707</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 56 No. 4 (2024): Acta Medica Indonesiana; 469</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2707/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 Amaylia Oehadian, Mohammad Ghozali, Sutiadi Kusuma, Lusi Mersiana, Nadia Gita Ghassani, Fransisca Fransisca, Yitzchak Millenard Sigilipu, Andini Kartikasari, Laniyati Hamijoyo</dc:rights>
</oai_dc:dc>